Impact on the Higgs Production Cross Section and Decay Branching Fractions of Heavy Quarks and Leptons in a Fourth Generation Model

In a fourth generation model with heavy quarks, the production cross section of the Higgs boson in the gluon-gluon fusion process is significantly increased due to additional quark loops. In a similar way, the partial decay width of the decay channels $H\rightarrow gg, \gamma \gamma$ and $\gamma Z$ is modified. These changes and their impact on the Higgs search are discussed.Comment: 9 pages, 6 figures, minor changes with a few more references adde

Treatment effect of Bushen Huayu extract on postmenopausal osteoporosis in vivo

Bushen Huayu extract (BSHY), a traditional Chinese medicine, has been demonstrated to treat postmenopausal osteoporosis, however, the underlying mechanism remains to be fully elucidated. The aim of the present study was to investigate the therapeutic effect of BSHY and the mechanisms underlying this effect in an in vivo postmenopausal osteoporosis animal model. A total of 1 g BSHY containing 7.12 μg icariin was prepared. Low-dose BSHY (BSHY-L; 11.1 g/kg), medium-dose BSHY (BSHY-M; 22.2 g/kg) and high-dose BSHY (BSHY-H; 44.4 g/kg) was administered to oophorectomized rats using intragastric infusion. Estradiol (E2), interleukin-6 (IL-6) and serum alkaline phosphatase (ALP) levels, as well as bone density, were determined. It was found that the levels of serum ALP in the BSHY-L, BSHY-M and BSHY-H groups (197.75±41.74, 166.63±44.83 and 165.63±44.90 IU/l, respectively) were significantly decreased compared with the model group (299.13±45.79 IU/l; P<0.05), whilst the levels of E2 (16.89±1.71, 17.95±1.40 and 18.34±1.43 pg/ml, respectively) increased compared with the model group (14.54±1.61; P<0.05). In addition, the levels of IL-6 decreased in the BSHY-L, BSHY-M and BSHY-H groups (91.85±14.81, 82.99±15.65 and 80.54±14.61 pg/ml, respectively) compared with the model group (105.93±16.50 pg/ml; P<0.05). Furthermore, it was demonstrated that BSHY increased the bone density in the BSHY-L, BSHY-M and BSHY-H groups (0.20±0.014, 0.22±0.016 and 0.22±0.017 g/cm2, respectively) compared with the model group (0.19±0.011 g/cm2; P<0.05). BSHY was also found to increase the number of osteoblasts in the BSHY-L, BSHY-M and BSHY-H groups (25.38±2.17, 29.25±2.12 and 30.00±2.39, respectively), compared with in the model group (14.75±2.38; P<0.05), and decrease the number of osteoclasts in the BSHY-L, BSHY-M and BSHY-H groups (4.00±1.85, 4.25±1.39 and 5.75±1.49, respectively) compared with 9.50±1.60 observed in the model group (P<0.05). These results suggest that BSHY is a potential therapeutic drug for the treatment of osteoporosis in vivo. Furthermore, these results suggest that the mechanism by which BSHY decreases the serum levels of IL-6 may be by regulating E2.published_or_final_versio

Relations Among Universal Equations For Gromov-Witten Invariants

In this paper, we study relations among known universal equations for Gromov-Witten invariants at genus 1 and 2.Comment: LaTex file, 13 page

Review of data-driven methods used to control the normalization of the top quark background contribution in the H --> WW(*) --> {\ellν\ellν} analyses at the LHC

A few data-driven methods used in deriving the normalization of the dominant top quark background contribution in the $H → WW(*) → {\ellν\ellν}$ analyses by the ATLAS and CMS experiments at the LHC are reviewed and compared. Additional information, justi fication or modi fication to some of the methods is provided. These methods have also been or can be applied to other analyses such as cross section measurements of the Standard Model WW process and searches for new physics in channels with similar final states

A novel 3D multi-path DenseNet for improving automatic segmentation of glioblastoma on pre-operative multi-modal MR images

Convolutional neural networks have achieved excellent results in automatic medical image segmentation. In this study, we proposed a novel 3D multi-path DenseNet for generating the accurate glioblastoma (GBM) tumor contour from four multi-modal pre-operative MR images. We hypothesized that the multi-path architecture could achieve more accurate segmentation than a single-path architecture. 258 GBM patients were included in this study. Each patient had four MR images (T1-weighted, contrast-enhanced T1-weighted, T2-weighted, and FLAIR) and the manually segmented tumor contour. We built a 3D multi-path DenseNet that could be trained to generate the corresponding GBM tumor contour from the four MR images. A 3D single-path DenseNet was also built for comparison. Both DenseNets were based on the encoder-decoder architecture. All four images were concatenated and fed into a single encoder path in the single-path DenseNet, while each input image had its own encoder path in the multi-path DenseNet. The patient cohort was randomly split into a training set of 180 patients, a validation set of 39 patients, and a testing set of 39 patients. Model performance was evaluated using the Dice similarity coefficient (DSC), average surface distance (ASD), and 95% Hausdorff distance (HD95%). Wilcoxon signed-rank tests were conducted to examine the model differences. The single-path DenseNet achieved a DSC of 0.911$\pm$0.060, ASD of 1.3$\pm$0.7 mm, and HD95% of 5.2$\pm$7.1 mm, while the multi-path DenseNet achieved a DSC of 0.922$\pm$0.041, ASD of 1.1$\pm$0.5 mm, and HD95% of 3.9$\pm$3.3 mm. The p-values of all Wilcoxon signed-rank tests were less than 0.05. Both 3D DenseNets generated GBM tumor contours in good agreement with the manually segmented contours from multi-modal MR images. The multi-path DenseNet achieved more accurate tumor segmentation than the single-path DenseNet.Comment: 15 pages, 6 figures, review in progres

Genetic Fusions of a CFA/I/II/IV MEFA (Multiepitope Fusion Antigen) and a Toxoid Fusion of Heat-Stable Toxin (STa) and Heat-Labile Toxin (LT) of Enterotoxigenic Escherichia coli (ETEC) Retain Broad Anti-CFA and Antitoxin Antigenicity

Citation: Ruan, X. S., Sack, D. A., & Zhang, W. P. (2015). Genetic Fusions of a CFA/I/II/IV MEFA (Multiepitope Fusion Antigen) and a Toxoid Fusion of Heat-Stable Toxin (STa) and Heat-Labile Toxin (LT) of Enterotoxigenic Escherichia coli (ETEC) Retain Broad Anti-CFA and Antitoxin Antigenicity. Plos One, 10(3), 20. doi:10.1371/journal.pone.0121623Immunological heterogeneity has long been the major challenge in developing broadly effective vaccines to protect humans and animals against bacterial and viral infections. Enterotoxigenic Escherichia coli (ETEC) strains, the leading bacterial cause of diarrhea in humans, express at least 23 immunologically different colonization factor antigens (CFAs) and two distinct enterotoxins [heat-labile toxin (LT) and heat-stable toxin type Ib (STa or hSTa)]. ETEC strains expressing any one or two CFAs and either toxin cause diarrhea, therefore vaccines inducing broad immunity against a majority of CFAs, if not all, and both toxins are expected to be effective against ETEC. In this study, we applied the multiepitope fusion antigen (MEFA) strategy to construct ETEC antigens and examined antigens for broad anti-CFA and antitoxin immunogenicity. CFA MEFA CFA/I/II/IV [CVI 2014, 21(2): 2439], which carried epitopes of seven CFAs [CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV (CS4, CS5, CS6)] expressed by the most prevalent and virulent ETEC strains, was genetically fused to LT-STa toxoid fusion monomer 3xSTa(A14Q)-dmLT or 3xSTa(N12S)-dmLT [IAI 2014, 82(5): 1823-32] for CFA/I/II/IV-STaA14Q-dmLT and CFA/I/II/IV-STaN12S-dmLT MEFAs. Mice intraperitoneally immunized with either CFA/I/II/IV-STa-(toxoid)-dmLT MEFA developed antibodies specific to seven CFAs and both toxins, at levels equivalent or comparable to those induced from co-administration of the CFA/I/II/IV MEFA and toxoid fusion 3xSTaN12S-dmLT. Moreover, induced antibodies showed in vitro adherence inhibition activities against ETEC or E. coli strains expressing these seven CFAs and neutralization activities against both toxins. These results indicated CFA/I/II/IV-STa-(toxoid)-dmLT MEFA or CFA/I/II/IV MEFA combined with 3xSTa(N12S)-dmLT induced broadly protective anti-CFA and antitoxin immunity, suggested their potential application in broadly effective ETEC vaccine development. This MEFA strategy may be generally used in multivalent vaccine development

Association of Exposure to Particular Matter and Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis

Background: Long time exposure to particular matter has been linked to myocardial infarction, stroke and blood pressure, but its association with atherosclerosis is not clear. This meta-analysis was aimed at assessing whether PM2.5 and PM10 have an effect on subclinical atherosclerosis measured by carotid intima-media thickness (CIMT). Methods: Pubmed, Ovid Medline, Embase and NICK between 1948 and 31 March 2015 were searched by combining the keywords about exposure to the outcome related words. The random-effects model was applied in computing the change of CIMT and their corresponding 95% confidence interval (95% CI). The effect of potential confounding factors was assessed by stratified analysis and the impact of traffic proximity was also estimated. Results: Among 56 identified studies, 11 articles satisfied the inclusion criteria. In overall analysis increments of 10 μg/m3 in PM2.5 and PM10 were associated with an increase of CIMT (16.79 μm; 95% CI, 4.95–28.63 μm and 4.13 μm; 95% CI, −5.79–14.04 μm, respectively). Results shown in subgroup analysis had reference value for comparing with those of the overall analysis. The impact of traffic proximity on CIMT was uncertain. Conclusions: Exposure to PM2.5 had a significant association with CIMT and for women the effect may be more obvious

SGXIO: Generic Trusted I/O Path for Intel SGX

Application security traditionally strongly relies upon security of the underlying operating system. However, operating systems often fall victim to software attacks, compromising security of applications as well. To overcome this dependency, Intel introduced SGX, which allows to protect application code against a subverted or malicious OS by running it in a hardware-protected enclave. However, SGX lacks support for generic trusted I/O paths to protect user input and output between enclaves and I/O devices. This work presents SGXIO, a generic trusted path architecture for SGX, allowing user applications to run securely on top of an untrusted OS, while at the same time supporting trusted paths to generic I/O devices. To achieve this, SGXIO combines the benefits of SGX's easy programming model with traditional hypervisor-based trusted path architectures. Moreover, SGXIO can tweak insecure debug enclaves to behave like secure production enclaves. SGXIO surpasses traditional use cases in cloud computing and makes SGX technology usable for protecting user-centric, local applications against kernel-level keyloggers and likewise. It is compatible to unmodified operating systems and works on a modern commodity notebook out of the box. Hence, SGXIO is particularly promising for the broad x86 community to which SGX is readily available.Comment: To appear in CODASPY'1

Inertia effect on buckling-induced auxetic metamaterials

Auxetic metamaterials have enhanced indentation and penetration resistance due to their high shear strength and modulus. Its auxetic performance under dynamic loading cases is an important property for shields and armour applications. In the present study, compressive tests at different impact velocities on buckling-induced auxetic metamaterials were conducted for two different initial geometries. A photographic technique was applied to measure the Poisson&#039;s ratio. When the dynamic data were compared with those of quasi-static experiments, it was found that the negative Poisson&#039;s ratio for the buckling-induced metamaterial is sensitive to the rate of loading, while the negative Poisson&#039;s ratio for the metamaterial with initial auxetic behaviour is insensitive to the loading rate. It was also found that the deformation pattern is similar to that in the quasi-static loading condition when the impact force measured by the test machine is dominated by the inertia force of the metamaterials