2,621 research outputs found

    Fog-enabled Edge Learning for Cognitive Content-Centric Networking in 5G

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    By caching content at network edges close to the users, the content-centric networking (CCN) has been considered to enforce efficient content retrieval and distribution in the fifth generation (5G) networks. Due to the volume, velocity, and variety of data generated by various 5G users, an urgent and strategic issue is how to elevate the cognitive ability of the CCN to realize context-awareness, timely response, and traffic offloading for 5G applications. In this article, we envision that the fundamental work of designing a cognitive CCN (C-CCN) for the upcoming 5G is exploiting the fog computing to associatively learn and control the states of edge devices (such as phones, vehicles, and base stations) and in-network resources (computing, networking, and caching). Moreover, we propose a fog-enabled edge learning (FEL) framework for C-CCN in 5G, which can aggregate the idle computing resources of the neighbouring edge devices into virtual fogs to afford the heavy delay-sensitive learning tasks. By leveraging artificial intelligence (AI) to jointly processing sensed environmental data, dealing with the massive content statistics, and enforcing the mobility control at network edges, the FEL makes it possible for mobile users to cognitively share their data over the C-CCN in 5G. To validate the feasibility of proposed framework, we design two FEL-advanced cognitive services for C-CCN in 5G: 1) personalized network acceleration, 2) enhanced mobility management. Simultaneously, we present the simulations to show the FEL's efficiency on serving for the mobile users' delay-sensitive content retrieval and distribution in 5G.Comment: Submitted to IEEE Communications Magzine, under review, Feb. 09, 201

    A novel approach to detect hot-spots in large-scale multivariate data

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    Background: Progressive advances in the measurement of complex multifactorial components of biological processes involving both spatial and temporal domains have made it difficult to identify the variables (genes, proteins, neurons etc.) significantly changed activities in response to a stimulus within large data sets using conventional statistical approaches. The set of all changed variables is termed hot-spots. The detection of such hot spots is considered to be an NP hard problem, but by first establishing its theoretical foundation we have been able to develop an algorithm that provides a solution. Results: Our results show that a first-order phase transition is observable whose critical point separates the hot-spot set from the remaining variables. Its application is also found to be more successful than existing approaches in identifying statistically significant hot-spots both with simulated data sets and in real large-scale multivariate data sets from gene arrays, electrophysiological recording and functional magnetic resonance imaging experiments. Conclusion: In summary, this new statistical algorithm should provide a powerful new analytical tool to extract the maximum information from complex biological multivariate data

    Uncovering interactions in the frequency domain

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    Oscillatory activity plays a critical role in regulating biological processes at levels ranging from subcellular, cellular, and network to the whole organism, and often involves a large number of interacting elements. We shed light on this issue by introducing a novel approach called partial Granger causality to reliably reveal interaction patterns in multivariate data with exogenous inputs and latent variables in the frequency domain. The method is extensively tested with toy models, and successfully applied to experimental datasets, including (1) gene microarray data of HeLa cell cycle; (2) in vivo multielectrode array (MEA) local field potentials (LFPs) recorded from the inferotemporal cortex of a sheep; and (3) in vivo LFPs recorded from distributed sites in the right hemisphere of a macaque monkey

    Membrane topology of the ArsB protein, the membrane subunit of an anion-translocating ATPase

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    The ars operon of the conjugative R-factor R773 encodes an oxyanion pump that catalyzes extrusion of arsenicals from cells of Escherichia coli. The oxyanion translocation ATPase is composed of two polypeptides, the catalytic ArsA protein and the intrinsic membrane protein, ArsB. The topology of regions of the ArsB protein in the inner membrane was determined using a variety of gene fusions. Random gene fusions with lacZ and phoA were generated using transposon mutagenesis. A series of gene fusions with blaM were constructed in vitro using a beta-lactamase fusion vector. To localize individual segments of the ArsB protein, a ternary fusion method was developed, where portions of the arsB gene were inserted in-frame between the coding regions for two heterologous proteins, in this case a portion of a newly identified arsD gene and the blaM sequence encoding the mature beta-lactamase. The location of a periplasmic loop was determined from V8 protease digestion of an ArsA-ArsB chimera. From analysis of data from 26 fusions, a topological model of the ArsB protein with 12 membrane-spanning regions is proposed

    Impact of environmental inputs on reverse-engineering approach to network structures

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    Background: Uncovering complex network structures from a biological system is one of the main topic in system biology. The network structures can be inferred by the dynamical Bayesian network or Granger causality, but neither techniques have seriously taken into account the impact of environmental inputs. Results: With considerations of natural rhythmic dynamics of biological data, we propose a system biology approach to reveal the impact of environmental inputs on network structures. We first represent the environmental inputs by a harmonic oscillator and combine them with Granger causality to identify environmental inputs and then uncover the causal network structures. We also generalize it to multiple harmonic oscillators to represent various exogenous influences. This system approach is extensively tested with toy models and successfully applied to a real biological network of microarray data of the flowering genes of the model plant Arabidopsis Thaliana. The aim is to identify those genes that are directly affected by the presence of the sunlight and uncover the interactive network structures associating with flowering metabolism. Conclusion: We demonstrate that environmental inputs are crucial for correctly inferring network structures. Harmonic causal method is proved to be a powerful technique to detect environment inputs and uncover network structures, especially when the biological data exhibit periodic oscillations

    Method Exploration of Self-adaptive Entity Matching in Map Fusion

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    AbstractEntity matching is a crucial and hard technology in map fusion. Current methods still exists some deficiencies, such as matching efficiency is not high, low degree of automation and poor universality, these methods can not meet the matching needs of large data integration, therefore, the urgent need to develop more effective and intelligent methods. This paper analyzed present research situation and existing problems of entity matching, illustrated the necessity of developing self-adaptive entity matching, pointed out urgent research contents and key issues that need to be resolved urgently in self-adaptive entity matching, provided preliminary research scheme of implementing self-adaptive entity matching, finally, introduced characteristics and advantages of self-adaptive entity matching method presented in this paper
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