The Writing on the [Fire] Wall: Mission Critical Cybersecurity Derivative Litigation is on Delaware\u27s Horizon

The impact of the information economy during the last quarter century has been dramatic. But for all its glory, the information economy also presents vulnerabilities: a cybersecurity breach can materially affect firm value. Although some security breaches may be inevitable in the modern world, courts are increasingly considering the question of whether the corporation’s directors and officers may be held liable under the theory that they acted in bad faith in their oversight of the corporation’s cybersecurity. To date, no suit has survived a motion to dismiss but several have settled for sizeable amounts. A watershed decision from the Delaware Supreme Court and a series of chancery court decisions may provide the opening plaintiffs’ lawyers have been looking for. With an unmatched data breach in SolarWinds, the writing is on the [fire]wall: Delaware corporations should brace themselves for “mission critical” cybersecurity derivative litigation

Examining the Effect of Physician Language on Physician Impressions

Previous research provides evidence that stigma can be perpetuated through language with consequences for well-being and quality of care. For example, providers who use stigmatizing language transmit bias toward patients with implications for care provided by other healthcare professionals. The current work extends upon this research by investigating perceptions of physicians who use stigmatizing or humanizing language. The current work sought to document the negative consequences of providers’ indelicate language on impressions of the provider, thereby motivating thoughtful language choices. To this end, the current work experimentally manipulated the language (stigmatizing, identity-first and destigmatizing, person-first) that hypothetical providers used to describe individuals with substance use disorder and examined participants’ judgments of the providers (likeability and positive behavioral intentions). We predicted that the provider using stigmatizing, identity-first language would elicit more negative responses than the provider using destigmatizing, person-first language. However, the results provided no support for this hypothesis; instead, we observed only an effect of the vignette content: participants had more positive perceptions of the physician who spoke first, compared to the physician who spoke second. Although the current work did not observe significant effects of language, past work indicates the importance of empathy, warmth, and respect from providers for patient well-being and outcome. We suggest directions for improving upon the current study, as well as possible topics for future research that may aid in understanding these important antecedents of inclusive and successful patient-physician interactions

Environmental exposure to polychlorinated biphenyls and p,p\u27-DDE and sperm sex-chromosome disomy

Background: Chromosomal abnormalities contribute substantially to reproductive problems, but the role of environmental risk factors has received little attention. Objectives: We evaluated the association of polychlorinated biphenyl (PCB) and dichlorodiphenyldichloroethylene (p,p´-DDE) exposures with sperm sex-chromosome disomy. Methods: We conducted a cross-sectional study of 192 men from subfertile couples. We used multiprobe fluorescence in situ hybridization (FISH) for chromosomes X, Y, and 18 to determine XX, YY, XY, and total sex-chromosome disomy in sperm nuclei. Serum was analyzed for concentrations of 57 PCB congeners and p,p´-DDE. Poisson regression models were used to calculate incidence rate ratios (IRRs) for disomy by exposure quartiles, controlling for demographic characteristics and semen parameters. Results: The median percent disomy was 0.3 for XX and YY, 0.9 for XY, and 1.6 for total sex-chromosome disomy. We observed a significant trend of increasing IRRs for increasing quartiles of p,p´-DDE in XX, XY, and total sex-chromosome disomy, and a significant trend of increasing IRRs for increasing quartiles of PCBs for XY and total sex-chromosome disomy; however, there was a significant inverse association for XX disomy. Conclusions: Our findings suggest that exposure to p,p´-DDE may be associated with increased rates of XX, XY, and total sex-chromosome disomy, whereas exposure to PCBs may be associated with increased rates of YY, XY, and total sex-chromosome disomy. In addition, we observed an inverse association between increased exposure to PCBs and XX disomy. Further work is needed to confirm these findings

Surface properties of Mars' polar layered deposits and polar landing sites

On December 3, 1999, the Mars Polar Lander and Mars Microprobes will land on the planet's south polar layered deposits near (76°S, 195°W) and conduct the first in situ studies of the planet's polar regions. The scientific goals of these missions address several poorly understood and globally significant issues, such as polar meteorology, the composition and volatile content of the layered deposits, the erosional state and mass balance of their surface, their possible relationship to climate cycles, and the nature of bright and dark aeolian material. Derived thermal inertias of the southern layered deposits are very low (50–100 J m^(−2) s^(−1/2) K^(−1)), suggesting that the surface down to a depth of a few centimeters is generally fine grained or porous and free of an appreciable amount of rock or ice. The landing site region is smoother than typical cratered terrain on ∼1 km pixel^(−1) Viking Orbiter images but contains low-relief texture on ∼5 to 100 m pixel^(−1) Mariner 9 and Mars Global Surveyor images. The surface of the southern deposits is older than that of the northern deposits and appears to be modified by aeolian erosion or ablation of ground ice

Environmental Exposure to Polychlorinated Biphenyls and p,p´-DDE and Sperm Sex-Chromosome Disomy

Background: Chromosomal abnormalities contribute substantially to reproductive problems, but the role of environmental risk factors has received little attention

Spatial Distribution and Thermal Diversity of Surface Volatile Cold Traps at the Lunar Poles

The polar regions of the Moon host some of the most extreme low temperatures in the inner solar system due to its low obliquity, lack of atmosphere, and topographic relief. Some of these regions are already confirmed to host water ice. Proposed sources of water and other volatiles include lunar volcanic outgassing, solar wind, and comet impacts. Each of these possible sources would carry a potentially identifiable compositional signature beyond water. Determining the dominant sources of lunar volatiles, therefore, requires assessing the long-term thermal stability of an array of compounds. We present results of mapping the surface thermal stability locations of multiple key volatiles, including water, from the Diviner Lunar Radiometer data from 60&deg; to 90&deg; latitude in both hemispheres. We find the annual maximum temperature for each pixel of interest in the map (&sim;300 m) to determine which volatiles of interest would be stable there. We report on the thermal stability area of each volatile, as well as the geologic context in some cases. We find that while the thermal stability area for volatiles is larger in the south pole generally, both the north pole and south pole host areas where potential tracer volatiles from lunar volcanism, solar wind, and cometary impacts would be thermally stable for billions of years if such volatiles were ever delivered. We find several areas equatorward of &sim;80&deg; on the lunar nearside that could host water ice, where future missions could potentially access volatile deposits in order to place constraints on water delivery to the Moon. &nbsp;</p

Predictors of Serum Chlorinated Pesticide Concentrations among Prepubertal Russian Boys

Background: Few studies have evaluated predictors of childhood exposure to organochlorine pesticides (OCPs), a class of lipophilic persistent chemicals. Objectives: Our goal was to identify predictors of serum OCP concentrations—hexachlorobenzene (HCB), β-hexachlorocyclohexane (β-HCH), and p,p-dichlorodiphenyldichloroethylene (p,p´-DDE)—among boys in Chapaevsk, Russia. Methods: Between 2003 and 2005, 499 boys 8–9 years of age were recruited in a prospective cohort. The initial study visit included a physical examination; blood collection; health, lifestyle, and food-frequency questionnaires; and determination of residential distance from a local factory complex that produced HCB and β-HCH. Fasting serum samples were analyzed for OCPs at the U.S. Centers for Disease Control and Prevention. General linear regression models were used to identify predictors of the boys’ serum HCB, β-HCH, and p,p´-DDE concentrations. Results: Among 355 boys with OCP measurements, median serum HCB, β-HCH, and p,p´-DDE concentrations were 158, 167, and 284 ng/g lipid, respectively. Lower body mass index, longer breastfeeding duration, and local dairy consumption were associated with higher concentrations of OCPs. Boys who lived 3 years in Chapaevsk predicted higher β-HCH concentrations, and having parents who lacked a high school education predicted higher p,p´-DDE concentrations. Conclusions: Among this cohort of prepubertal Russian boys, predictors of serum OCPs included consumption of local dairy products, longer local residence, and residential proximity to the local factory complex. Citation: Lam T, Williams PL, Burns JS, Sergeyev O, Korrick SA, Lee MM, Birnbaum LS, Revich B, Altshul LM, Patterson DG Jr, Turner WE, Hauser R. 2013. Predictors of serum chlorinated pesticide concentrations among prepubertal Russian boys. Environ Health Perspect 121:1372–1377; http://dx.doi.org/10.1289/ehp.130648