408 research outputs found
An estuarine box model of freshwater delivery to the coastal ocean for use in climate models
Present day climate models employ a coarse horizontal grid that is unable to fully resolve estuaries or continental shelves. The importation of fresh water from rivers is critical to the state of deep ocean stratification, but currently the processing of that fresh water as it passes from the river through the estuary and adjacent shelf is not represented in the coastal boundary conditions of climate models. An efficient way to represent this input of fresh water to the deep ocean would be to treat the estuary and shelf domains as two coupled box models with river water input to the estuarine box and mixed fresh water and coastal water output from the shelf box to the deep ocean.We develop and test the estuary box model here. The potential energy anomaly Ï• is found from the five competing rates of change induced by freshwater inflow, mixed water outflow to the shelf, tidal mixing, surface heat flux, and wind-induced mixing. When application of the box model is made to the Delaware estuary, the wind mixing term contributes little. A 15-year time series of Ï• compares surprisingly well with the calculations of a three-dimensional numerical model applied to the Delaware estuary. The results encourage the future development of a shelf box model as the next step in constructing needed boundary conditions for input of fresh water to the deep ocean component of coupled climate models
Energetics in Delaware Bay: Comparison of two box models with observations
A corrected version of an unstratified box model of potential energy anomaly , initially developed by Garvine and Whitney (2006), and a new two-layer box model that allows for stratified and well-mixed conditions are applied to Delaware Bay. The models are applied for the Garvine and Whitney (2006) 1988-1994 study period and in Spring 2003; however, only model results of potential energy anomaly from the latter period are compared to in situ observations obtained outside the bay mouth. Unstratified model results for the two study periods reveal that the river discharge (Ω1) is the largest potential energy anomaly contributor. This term is closely followed (but with opposite sign) by the coastal current efflux term (Ω2). For the two-layer model the largest contributor is the dense inflow term (Ω6). The wind term (Ω5) is the second largest, followed by the tide (Ω3), river discharge (Ω1) and coastal current terms. In both models the solar heat flux term (Ω4) makes the smallest contribution to ϕ. The available one-month comparison of model results to observations renders statistically insignificant correlation coefficients for both models. We speculate dynamical differences between conditions at the estuary mouth and the instrument location on the nearby shelf contribute to the model-observation mismatch. Other statistics, such as the root mean square error indicate that the unstratified model performs better than the two-layer model for the observation period. The latter model is, however, able to depict the importance of tides and winds in the computation of potential energy anomaly and is able to detect the response of ϕ due to strong wind events. While there is no clear model choice for the Delaware Bay, the unstratified model may be entirely inappropriate for highly stratified estuaries
Endothelial Dysfunction Criteria in Critically Ill Children: The PODIUM Consensus Conference
OBJECTIVES
To review, analyze, and synthesize the literature on endothelial dysfunction in critically ill children with multiple organ dysfunction syndrome and to develop a consensus biomarker-based definition and diagnostic criteria.
DATA SOURCES
Electronic searches of PubMed and Embase were conducted from January 1992 to January 2020, using a combination of medical subject heading terms and key words to define concepts of endothelial dysfunction, pediatric critical illness, and outcomes.
STUDY SELECTION
Studies were included if they evaluated critically ill children with endothelial dysfunction, evaluated performance characteristics of assessment/scoring tools to screen for endothelial dysfunction, and assessed outcomes related to mortality, functional status, organ-specific outcomes, or other patient-centered outcomes. Studies of adults or premature infants (≤36 weeks gestational age), animal studies, reviews or commentaries, case series with sample size ≤10, and non-English language studies with the inability to determine eligibility criteria were excluded.
DATA EXTRACTION
Data were abstracted from each eligible study into a standard data extraction form along with risk of bias assessment.
DATA SYNTHESIS
We identified 62 studies involving 84 assessments of endothelial derived biomarkers indirectly linked to endothelial functions including leukocyte recruitment, inflammation, coagulation, and permeability. Nearly all biomarkers studied lacked specificity for vascular segment and organ systems. Quality assessment scores for the collected literature were low.
CONCLUSIONS
The Endothelial Subgroup concludes that there exists no single or combination of biomarkers to diagnose endothelial dysfunction in pediatric multiple organ dysfunction syndrome. Future research should focus on biomarkers more directly linked to endothelial functions and with specificity for vascular segment and organ systems
NASA Marshall Impact Testing Facility Capabilities Applicable to Lunar Dust Work
The Impact Testing Facility at Marshall Space Flight Center has several guns that would be of use in studying impact phenomena with respect to lunar dust. These include both ballistic guns, using compressed gas and powder charges, and hypervelocity guns, either light gas guns or an exploding wire gun. In addition, a plasma drag accelerator expected to reach 20 km/s for small particles is under development. Velocity determination and impact event recording are done using ultra-high-speed cameras. Simulation analysis is also available using the SPHC hydrocode
Pumps for low pressure ground sprayers
The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311.Biosystems and Agricultural Engineerin
The Effects of Exercise and a Low-Fat Diet on Monocyte TLR Expression and Disease Risk in Mice
Excess adiposity increases systemic inflammation, which is implicated in various diseases. Physical activity is a common treatment to reverse weight gain and increased disease risk; however, little evidence is available to determine if forced or voluntary exercise is more effective in mice. Such information has implications for the refinement of human exercise interventions. PURPOSE: To determine if 8-weeks of exercise combined with low-fat feeding reverses changes in disease risk, monocyte concentration and monocyte TLR2/TLR4 expression. METHODS: For 12-months, 24 CD-1 mice underwent pre-treatment, consuming either a low-fat (10% kcal from fat, N=6) or high-fat (60% kcal from fat, N=18) diet ad libitum. High-fat fed mice were randomly assigned to one of three groups (N=6/group): V-EX (low-fat chow, access to running wheel 5 d/week), F-EX (low-fat chow, forced treadmill running at 22 m/min, 60-min/d, 5 d/week), or SD (low-fat chow, no exercise). Mice pre-treated with low-fat chow served as controls (CN, N=6). Measurements were made on weekly saphenous vein blood samples using 3-color flow cytometry. Blood glucose and cholesterol concentration were analyzed weekly using a glucose and cholesterol analyzer. IPGTT was performed at baseline and week 8 and analyzed as area under the curve. RESULTS: All groups lost significant body weight over 8-weeks (P\u3c0.001). V-EX ran 4.4x more than F-EX (P\u3c0.001). There were no significant effects for blood cholesterol. CN had 26% higher glucose levels than V-EX (P=0.009). On average, there was a 59% decrease in IPGTT AUC from baseline to week 8 and V-EX decreased 37% more than CN. At week 8, monocyte concentration was 6x higher than week 1 (P=0.002). Specifically, V-EX was greater than both CN (49%) and F-EX (59%). Cell-surface TLR2 expression was significantly greater at week 6 (55%) and week 8 (23%) relative to baseline. Monocyte cell-surface TLR4 expression increased from baseline to week 8 (P\u3c0.001). CONCLUSIONS: Combining low-fat diet and exercise caused significantly more weight loss than low-fat diet alone. Overall, there was decreased insulin resistance and decreased glucose, suggesting there may have been a decrease in type II diabetes risk. Lack of difference in monocyte concentration and TLR2/4 cell-surface expression suggest the diet and exercise intervention was not long enough to elicit changes in inflammation following the long-term high-fat feeding. More research is needed to understand the time course of these changes. This study was useful in understanding what occurs during a diet and exercise intervention and in directly comparing forced and voluntary exercise
Selecting nozzles for low pressure ground sprayers
The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311.Biosystems and Agricultural Engineerin
Calibrating a low pressure ground sprayer
The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311
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