Recovery from psychosis : physical health, antipsychotic medication and the daily dilemmas for mental health nurses

This paper considers some of the dilemmas experienced by Mental Health Nurses everyday when faced with the seemingly conflicting relationships that exist between recovery, antipsychotics and the physical health of people experiencing psychosis. We examine the role of antipsychotics in the process of recovery from psychosis and argue that Mental Health Nursing’s laudable shift away from the medical model towards the concept of self-defined personal recovery should not result in overlooking the importance of physical health and medication management. Mental Health Nurses have a responsibility to help services users make an informed choice about treatment; this exchange of information should be based on the best available evidence rather than philosophical values or personal opinion

The strength and timing of the mitochondrial bottleneck in salmon suggests a conserved mechanism in vertebrates

In most species mitochondrial DNA (mtDNA) is inherited maternally in an apparently clonal fashion, although how this is achieved remains uncertain. Population genetic studies show not only that individuals can harbor more than one type of mtDNA (heteroplasmy) but that heteroplasmy is common and widespread across a diversity of taxa. Females harboring a mixture of mtDNAs may transmit varying proportions of each mtDNA type (haplotype) to their offspring. However, mtDNA variants are also observed to segregate rapidly between generations despite the high mtDNA copy number in the oocyte, which suggests a genetic bottleneck acts during mtDNA transmission. Understanding the size and timing of this bottleneck is important for interpreting population genetic relationships and for predicting the inheritance of mtDNA based disease, but despite its importance the underlying mechanisms remain unclear. Empirical studies, restricted to mice, have shown that the mtDNA bottleneck could act either at embryogenesis, oogenesis or both. To investigate whether the size and timing of the mitochondrial bottleneck is conserved between distant vertebrates, we measured the genetic variance in mtDNA heteroplasmy at three developmental stages (female, ova and fry) in chinook salmon and applied a new mathematical model to estimate the number of segregating units (N(e)) of the mitochondrial bottleneck between each stage. Using these data we estimate values for mtDNA Ne of 88.3 for oogenesis, and 80.3 for embryogenesis. Our results confirm the presence of a mitochondrial bottleneck in fish, and show that segregation of mtDNA variation is effectively complete by the end of oogenesis. Considering the extensive differences in reproductive physiology between fish and mammals, our results suggest the mechanism underlying the mtDNA bottleneck is conserved in these distant vertebrates both in terms of it magnitude and timing. This finding may lead to improvements in our understanding of mitochondrial disorders and population interpretations using mtDNA data

A New Generating Function for Calculating the Igusa Local Zeta Function

A new method is devised for calculating the Igusa local zeta function $Z_f$ of a polynomial $f(x_1,\dots,x_n)$ over a $p$-adic field. This involves a new kind of generating function $G_f$ that is the projective limit of a family of generating functions, and contains more data than $Z_f$. This $G_f$ resides in an algebra whose structure is naturally compatible with operations on the underlying polynomials, facilitating calculation of local zeta functions. This new technique is used to expand significantly the set of quadratic polynomials whose local zeta functions have been calculated explicitly. Local zeta functions for arbitrary quadratic polynomials over $p$-adic fields with $p$ odd are presented, as well as for polynomials over unramified $2$-adic fields of the form $Q+L$ where $Q$ is a quadratic form and $L$ is a linear form where $Q$ and $L$ have disjoint variables. For a quadratic form over an arbitrary $p$-adic field with odd $p$, this new technique makes clear precisely which of the three candidate poles are actual poles.Comment: 54 page

An empirical evaluation of four variants of a universal species-area relationship

The Maximum Entropy Theory of Ecology (METE) predicts a universal species-area relationship (SAR) that can be fully characterized using only the total abundance (N) and species richness (S) at a single spatial scale. This theory has shown promise for characterizing scale dependence in the SAR. However, there are currently four different approaches to applying METE to predict the SAR and it is unclear which approach should be used due to a lack of empirical evaluation. Specifically, METE can be applied recursively or a non-recursively and can use either a theoretical or observed species-abundance distribution (SAD). We compared the four different combinations of approaches using empirical data from 16 datasets containing over 1000 species and 300,000 individual trees and herbs. In general, METE accurately downscaled the SAR (R^2> 0.94), but the recursive approach consistently under-predicted richness, and METEs accuracy did not depend strongly on using the observed or predicted SAD. This suggests that best approach to scaling diversity using METE is to use a combination of non-recursive scaling and the theoretical abundance distribution, which allows predictions to be made across a broad range of spatial scales with only knowledge of the species richness and total abundance at a single scale.Comment: main text: 20 pages, 2 tables, 3 figure

The Economics of Efficient Phosphorus Abatement in a Watershed

This study presents a method to determine efficient environmental targets at a watershed level. Efficient targets are devised by estimating abatement cost and cost of environmental damages and minimizing their sum. The method was applied to a case study of phosphorus pollution in a watershed in Oklahoma. Several cumulative scenarios with alternative abatement options were simulated and efficient targets were determined. As the number of abatement options at disposal to agricultural sources increased, their optimal abatement expanded relative to the abatement at the point source. Efficient targets were found to be dependent on the choice of policy that stimulates abatement.efficiency, environmental targets, phosphorus pollution, watershed, Resource /Energy Economics and Policy,

Economic Analysis of Management Practices to Reduce Phosphorus Load to Lake Eucha and Spavinaw

Changes in management practices are often proposed to reduce phosphorus loading from a watershed due to over application of poultry litter. This study determines the choice, location, and level of each best management practice in the watershed to meet a Total Maximum Daily Load and margins of safety at least cost.best management practice, phosphorus runoff, poultry litter, Target MOTAD, Environmental Economics and Policy,

Short-Term Memory in Orthogonal Neural Networks

We study the ability of linear recurrent networks obeying discrete time dynamics to store long temporal sequences that are retrievable from the instantaneous state of the network. We calculate this temporal memory capacity for both distributed shift register and random orthogonal connectivity matrices. We show that the memory capacity of these networks scales with system size.Comment: 4 pages, 4 figures, to be published in Phys. Rev. Let

Imprint of Inhomogeneous Reionization on the Power Spectrum of Galaxy Surveys at High Redshifts

We consider the effects of inhomogeneous reionization on the distribution of galaxies at high redshifts. Modulation of the formation process of the ionizing sources by large scale density modes makes reionization inhomogeneous and introduces a spread to the reionization times of different regions with the same size. After sources photo-ionize and heat these regions to a temperature \ga 10^4K at different times, their temperatures evolve as the ionized intergalactic medium (IGM) expands. The varying IGM temperature makes the minimum mass of galaxies spatially non-uniform with a fluctuation amplitude that increases towards small scales. These scale-dependent fluctuations modify the shape of the power spectrum of low-mass galaxies at high redshifts in a way that depends on the history of reionization. The resulting distortion of the primordial power spectrum is significantly larger than changes associated with uncertainties in the inflationary parameters, such as the spectral index of the scalar power spectrum or the running of the spectral index. Future surveys of high-redshift galaxies will offer a new probe of the thermal history of the IGM but might have a more limited scope in constraining inflation.Comment: 8 pages, 5 figures, replaced to match version accepted by Ap

Theoretical uncertainty in baryon oscillations

We discuss the systematic uncertainties in the recovery of dark energy properties from the use of baryon acoustic oscillations as a standard ruler. We demonstrate that while unknown relativistic components in the universe prior to recombination would alter the sound speed, the inferences for dark energy from low-redshift surveys are unchanged so long as the microwave background anisotropies can measure the redshift of matter-radiation equality, which they can do to sufficient accuracy. The mismeasurement of the radiation and matter densities themselves (as opposed to their ratio) would manifest as an incorrect prediction for the Hubble constant at low redshift. In addition, these anomalies do produce subtle but detectable features in the microwave anisotropies.Comment: 4 pages, REVTeX, 1 figure. Submitted to PR

Fibrous-Ceramic/Aerogel Composite Insulating Tiles

Fibrous-ceramic/aerogel composite tiles have been invented to afford combinations of thermal-insulation and mechanical properties superior to those attainable by making tiles of fibrous ceramics alone or aerogels alone. These lightweight tiles can be tailored to a variety of applications that range from insulating cryogenic tanks to protecting spacecraft against re-entry heating. The advantages and disadvantages of fibrous ceramics and aerogels can be summarized as follows: Tiles made of ceramic fibers are known for mechanical strength, toughness, and machinability. Fibrous ceramic tiles are highly effective as thermal insulators in a vacuum. However, undesirably, the porosity of these materials makes them permeable by gases, so that in the presence of air or other gases, convection and gas-phase conduction contribute to the effective thermal conductivity of the tiles. Other disadvantages of the porosity and permeability of fibrous ceramic tiles arise because gases (e.g., water vapor or cryogenic gases) can condense in pores. This condensation contributes to weight, and in the case of cryogenic systems, the heat of condensation undesirably adds to the heat flowing to the objects that one seeks to keep cold. Moreover, there is a risk of explosion associated with vaporization of previously condensed gas upon reheating. Aerogels offer low permeability, low density, and low thermal conductivity, but are mechanically fragile. The basic idea of the present invention is to exploit the best features of fibrous ceramic tiles and aerogels. In a composite tile according to the invention, the fibrous ceramic serves as a matrix that mechanically supports the aerogel, while the aerogel serves as a low-conductivity, low-permeability filling that closes what would otherwise be the open pores of the fibrous ceramic. Because the aerogel eliminates or at least suppresses permeation by gas, gas-phase conduction, and convection, the thermal conductivity of such a composite even at normal atmospheric pressure is not much greater than that of the fibrous ceramic alone in a vacuum