Work, income and food insecurity: Families in Tower Hamlets community survey and panel findings

Summarizes findings from a survey and panel of families in Tower Hamlets in relation to work and insecurit

Young children's lives during the pandemic: Families in Tower Hamlets survey and panel findings

Young children were not in focus during the Covid-19 pandemic. This briefing summarises results from a study of the impacts of Covid-19 on families with young children in one east London borough. Young children's lives were dramatically curtailed. Analyses by ethnic group and household income show that some children were more disadvantaged than others

Access to community services and support through family and friends during the pandemic: Families in Tower Hamlets survey and panel findings

Summarises findings of a survey and panel of ESRC funded Families in Tower Hamlets, services and communitie

Pandemic impacts on Family Lives and Parental Wellbeing: Families in Tower Hamlets survey and panel findings

Families in Tower Hamlets was a study of 992 parents and parents to be during the Covid-19 pandemic. This briefing is one of five papers, summarizing findings in relation to families lives and wellbeing

Young children's lives in East London through the pandemic: Relationships, activities and social worlds

Children's lives in the Covid-19 pandemic were subject to unparalleled restrictions on and disruption to their daily lives. This paper explores the day-to-day relational, social participation and activities of young children in one East London borough in early 2021, as told through qualitative interviews with their parents. We adopt a social-ecological model of children's development, a child rights focused understanding of well-being, underpinned by an agentic view of both parents and children. We find that for some children, parents had additional time to spend with them and new activities were possible. But for others, particularly those living ‘compressed lives’ in low-income households and over-crowded accommodation with no outside space of their own, all three aspects—relational, participatory and activities—were significantly diminished

Brief Report: Is Impaired Classification of Subtle Facial Expressions in Children with Autism Spectrum Disorders Related to Atypical Emotion Category Boundaries?

Impairments in recognizing subtle facial expressions, in individuals with autism spectrum disorder (ASD), may relate to difficulties in constructing prototypes of these expressions. Eighteen children with predominantly intellectual low-functioning ASD (LFA, IQ <80) and two control groups (mental and chronological age matched), were assessed for their ability to classify emotional faces, of high, medium and low intensities, as happy or angry. For anger, the LFA group made more errors for lower intensity expressions than the control groups, classifications did not differ for happiness. This is the first study to find that the LFA group made more across-valence errors than controls. These data are consistent with atypical facial expression processing in ASD being associated with differences in the structure of emotion categories

Young children’s lives during the pandemic: Families in Tower Hamlets survey and panel findings

One of a series of briefings about the findings of the UKRI funded Families in Tower Hamlets study of families lives during the Covid-19 pandemic in relation to children's live

Housing and environment for young children during the pandemic: Families in Tower Hamlets community survey and panel findings

Discusses findings from UKRI funded study of Families in Tower Hamlets in relation to housing and environment during the Covid-19 pandemi

Genome-wide association reveals a locus in neuregulin 3 associated with gabapentin efficacy in women with chronic pelvic pain

Chronic pelvic pain (CPP) in women with no obvious pelvic pathology has few evidence-based treatment options. Our recent multicenter randomized controlled trial (GaPP2) in women with CPP and no obvious pelvic pathology showed that gabapentin did not relieve pain overall and was associated with more side effects than placebo. We conducted an exploratory genome-wide association study using eligible GaPP2 participants aiming to identify genetic variants associated with gabapentin response. One genome-wide significant association with gabapentin analgesic response was identified, rs4442490, an intron variant located in Neuregulin 3 (NRG3) (p = 2·11×10−8; OR = 18·82 (95% CI 4·86–72·83). Analysis of a large sample of UK Biobank participants demonstrated phenome-wide significant brain imaging features of rs4442490, particularly implicating the orbitofrontal cortex. NRG3 is expressed predominantly in central nervous system tissues and plays a critical role in nervous system development, maintenance, and repair, suggesting a neurobiologically plausible role in gabapentin efficacy and potential for personalized analgesic treatment