4 research outputs found

    Silver-Catalyzed Radical Arylphosphorylation of Unactivated Alkenes: Synthesis of 3‑Phosphonoalkyl Indolines

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    A silver-catalyzed phosphorylation/cyclization cascade of <i>N</i>-allyl anilines was developed, allowing direct access to 3-phosphonoalkyl indolines, which were previously obtainable only via tedious procedures under harsh/toxic conditions. The unactivated double bond serves as the radical acceptor, whereas H-phosphonates or -phosphine oxides act as the radical precursor. This protocol features simple operation, broad substrate scope, and great <i>exo</i> selectivity, and a gram-scale synthesis could be readily carried out

    Catalyst-free synthesis of 3-(1-arylsulfonylalkyl)indoles via three-component reaction of indoles, carbonyls, and arenesulfinic acids

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    <p>A catalyst-free three-component reaction of indoles, carbonyls, and arenesulfinic acids performed at room temperature provides direct access to biologically important 3-(1-arylsulfonylalkyl)indoles. This process features mild conditions, low cost, broad substrate scope, and high yields, and mechanistically bis(indolyl)methanes were identified as the key intermediates.</p

    Three-Component Reactions of Ketene Dithioacetals, Aldehydes, and Arenesulfinic Acids: Facile Synthesis of Allylic Sulfones

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    <div><p></p><p>A facile and efficient synthesis of allylic sulfones via sulfuric acid–mediated three-component reactions of easily available ketene dithioacetals, aldehydes, and arenesulfinic acids is presented. The reaction features low cost and good yields.</p> </div

    Butyrolactones derivatives from the fermentation products of a plant entophytic fungus <i>Penicillium oxalicum</i>

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    <div><p>Two new butyrolactone derivatives, terrelactones A and B (<b>1</b> and <b>2</b>), together with four known butyrolactone derivatives (<b>3</b>–<b>6</b>), were isolated from the fermentation products of the fungus <i>Penicillium oxalicum</i> 0403. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The anti-tobacco mosaic virus (anti-TMV) activities of <b>1</b> and <b>2</b> were evaluated. The results showed that compounds <b>1</b> and <b>2</b> exhibited high anti-TMV activity with inhibition rates of 25.5% and 27.4%, respectively. The inhibition rate is close to that of positive control (28.9%).</p></div
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