Be Kinder to Yourself: Awe Promotes Self-Compassion via Self-Transcendence

Deficits in self-compassion heighten the vulnerability of mental disorders and jeopardize well-being, emphasizing the necessity of fostering self-compassion during unexpected suffering. In this research, we investigate awe as an antecedent for promptly promoting self-compassion. Across five studies (three preregistered), employing various self-compassion metrics (self-report scale and behaviors) and testing in both controlled and natural settings, we found that awe was positively associated with, or promoted, self-reported self-compassion (Studies 1, 2, 4, and 5) and self-compassionate behaviors in real life (Study 5). These effects were distinct from general positive emotions (Studies 1 and 4) or nature exposure (Study 4). We further found that self-transcendence mediated this effect (Studies 2, 4, and 5) beyond self-diminishment (Study 4) and had a causal effect on promoting self-compassion (Study 3). These findings imply that awe enhances self-compassion via self-transcendence. </p

Structural Optimization of the Natural Product: Discovery of Almazoles C–D and Their Derivatives as Novel Antiviral and Anti-phytopathogenic Fungus Agents

Plant diseases seriously affect the growth of crops and the quality and yield of agricultural products. The search for plant-derived pesticide candidates based on natural products is a hot topic of current research. Marine natural products almazoles C–D were efficiently prepared and selected as the lead compounds in this work. Two series of almazole derivatives were designed and synthesized, and their antiviral and fungicidal activities were systematically evaluated. The results of anti-tobacco mosaic virus (anti-TMV) activity showed that almazoles C–D and their derivatives had good anti-TMV activities. Compounds 6, 15, 16a, 16b, 16g, 16l, 16n, 20a, 20d, 20i, and 20n exhibited better anti-TMV activities than the commercial antiviral agent ribavirin. Anti-TMV mechanism studies showed that compound 16b could induce the polymerization of 20S CP (coat protein, CP), thereby affecting the assembly of TMV virus particles. Molecular docking results showed that compounds 15, 16b, and 20n could combine with amino acid residues through hydrogen bonds to achieve an excellent anti-TMV effect. In addition, most of the almazole derivatives were found to have broad-spectrum fungicidal activities against eight kinds of plant pathogens (Fusarium oxysporum f. sp. cucumeris, Cercospora arachidicola Hori, Physalospora piricola, Rhizoctonia cerealis, Alternaria solani, Pyricularia grisea, Phytophthora capsici, and Sclerotinia sclerotiorum). This study provides an important evidence for the research and development of almazole alkaloids containing indole and oxazole structural groups as novel agrochemicals