Additional file 1 of Prevalence and distribution patterns of allergens among children with asthma and asthma-like symptoms in Shanghai, China

Additional file 1. Supplemental material 1: Distribution the probability of food allergen in children with asthma/ALS. Supplemental material 2: Non-linear relationship between age and the probability of aeroallergen. Supplemental material 3: Non-linear relationship between age and the probability of food allergen. Supplemental material 4: Non-linear relationship between age and the intensity of DF allergen. Supplemental material 5: Non-linear relationship between age and the intensity of HDM allergen. Supplemental material 6: Non-linear relationship between age and the intensity of shrimp allergen. Supplemental material 8: The intensity of DF allergen among groups with different parental allergy history. Supplemental material 9: The intensity of HDM allergen among groups with different parental allergy history. Supplemental material 10: The intensity of DF allergen among different groups. Supplemental material 11: The intensity of HDM allergen among different groups

Density Functional Theory Studies on the Structures and Water-Exchange Reactions of Aqueous Al(III)–Oxalate Complexes

The structures and water-exchange reactions of aqueous aluminum-oxalate complexes are investigated using density functional theory. The present work includes (1) The structures of Al(C2O4)(H2O)4+ and Al(C2O4)2(H2O)2– were optimized at the level of B3LYP/6-311+G(d,p). The geometries obtained suggest that the AlOH2 bond lengths trans to C2O42‑ ligand in Al(C2O4)(H2O)4+ are much longer than the AlOH2 bond lengths cis to C2O42‑. For Al(C2O4)2(H2O)2–, the close energies between cis and trans isomers imply the coexistence in aqueous solution. The 27Al NMR and 13C NMR chemical shifts computed with the consideration of sufficient solvent effect using HF GIAO method and 6-311+G(d,p) basis set are in agreement with the experimental values available, indicating the appropriateness of the applied models; (2) The water-exchange reactions of Al(III)–oxalate complexes were simulated at the same computational level. The results show that water exchange proceeds via dissociative pathway and the activation energy barriers are sensitive to the solvent effect. The energy barriers obtained indicate that the coordinated H2O cis to C2O42‑ in Al(C2O4)(H2O)4+ is more labile than trans H2O. The water-exchange rate constants (kex) of trans- and cis-Al(C2O4)2(H2O)2– were estimated by four methods and their respective characteristics were explored; (3) The significance of the study on the aqueous aluminum-oxalate complexes to environmental chemistry is discussed. The influences of ubiquitous organic ligands in environment on aluminum chemistry behavior can be elucidated by extending this study to a series of Al(III)–organic system

Theoretical Studies of the Formation Mechanisms, Thermodynamic Stabilities, and Water-Exchange Reactivities of Aluminum-Salicylate Complexes in Aqueous Solution

The formation mechanisms, thermodynamic stabilities, and water-exchange reactivities of 1:1 monomer aluminum–salicylate (Al–salicylate) complexes in acidic aqueous solution are investigated using the density functional theory-quantum chemical cluster model (DFT-CM) method. (1) The formation pathways for possible monodentate and bidentate Al–salicylate configurations are modeled with the gas phase-supermolecule-polarizable continuum model (GP-SM-PCM). It shows that the formation pathways for the Al–salicylate complexes follow the Eigen-Wilkins mechanism, where the dissociation of an inner-shell coordinated water of Al³⁺ is the rate-determining step. (2) The formation constants <i>K</i>_aq for different Al–salicylate configurations are estimated based on the total Gibbs free energy changes Δ<i>G</i>° for their overall formation pathways. It is indicated that in the acidic aqueous solution at pH ∼ 3, the main existence form of the 1:1 monomer Al–salicylate complex is the phenol-deprotonated bidentate Al­(Sal)­(H₂O)₄⁺ with six-membered ring. Its log <i>K</i>_aq is calculated as 13.8, in good agreement with the literature values of 12.9–14.5. (3) The water-exchange reactions are modeled for different Al–salicylate configurations. The water-exchange rate constant for Al­(Sal)­(H₂O)₄⁺ is estimated as log <i>k</i>_H2O = 3.9 s^–1, close to the experimental value of 3.7 s^–1. It proves again that this configuration is the dominant form under experimental conditions

Additional file 1 of Community-embedded follow-up management intervention for geriatric primary care: a mixed-methods study of an integrated health services model

Supplementary Material

Additional file 1 of MIR210HG promotes breast cancer progression by IGF2BP1 mediated m6A modification

Additional file 1: File 1. Table S1. Primers used in q-PCR analysis. Table S2. Primary antibodies used in western blot, q-ChIP and IHC. Table S3. Primers used in liciferase assay. Table S4. Primers used in qChIP analysis. File 2. Original gels

One Stone Three Birds: Na–Zr Co-Doping and Li₆Zr₂O₇ Coating Enhance the Structural Stability and Electrochemical Performance of the LiNi_0.8Co_0.1Mn_0.1O₂ Cathode Material

High nickel cathode materials have a superior energy density. However, LiNi0.8Co0.1Mn0.1O2 (NCM) commercial application is hindered by the bulk phase and interface instability. In the study, a “one stone three birds” tactic is designed to advance structural stability and electrochemical capability of material by Na–Zr codoping and Li6Zr2O7 coating. Na+ acts as a pillar in the lithium layer, extending the diffusion channel of Li+ and prohibiting the phase transition. The bond energy of Zr–O can strengthen the NCM lattice. As a lithium-ion conductor, Li6Zr2O7 also can speed up the diffusion of Li+ and prevent the electrolyte from coming into contact with the cathode materials. Thanks to the triple modification effect, the capacity retention rate reaches 91.39% at 1C after 200 cycles

List of impoverished counties in Sichuan.

Widespread vaccination against important diseases plays a key role for global health security, particularly in the context of the COVID-19 pandemic. However, building and maintaining trust in immunization services remains challenging because of doubts about quality and safety of vaccines. China has periodically faced mounting pressure and even public outrage triggered by incidents of poor-quality vaccines. We aimed to evaluate the impact of the diphtheria, pertussis, and tetanus (DPT) vaccine scandal of 2018 in China and the ensuing misinformation on vaccination, and investigate differential responses to the scandal by ethnic and socioeconomic factors. With data from January 2017 to December 2018 in Sichuan province, China, we used a difference-in-differences (DID) method to compare the changes in the county-level monthly DPT vaccinations against the hepatitis B vaccinations, both before and after the DPT vaccine scandal. We found that the number of DPT vaccinations decreased by 14.0 percent in response to the vaccine scandal and ensuing misinformation. The number of vaccinations in minority regions, under-developed regions, and regions with poor medical resources decreased more than in non-minority regions, developed regions, and regions with good medical resources (24.5 versus 10.1 percent, 17.3 versus 8.3 percent, and 17.0 versus 8.7 percent, respectively). People did more online searching for “Substandard vaccine” and “DPT vaccine” after the scandal, with the socioeconomically advantaged group searching more compared with the socioeconomically disadvantaged group. The results suggest the urgent need to make true information about the vaccine easily accessible over the internet, especially for the socioeconomically disadvantaged groups. Our findings for China can also have implications for immunization service planning for better safeguarding public health in other countries, particularly developing ones.</div

Efficient Si Doping Promoting Thermoelectric Performance of Yb-Filled CoSb₃‑Based Skutterudites

Nanocomposites have become a widely popular way to assist in the enhancement of thermoelectric performance for filled skutterudites. Herein, we unveil the distinctive effect of Si doping on the classic Yb0.3Co4Sb12. On the one hand, the reduced Yb filling fraction is accompanied by the in-situ precipitated CoSi nanoparticles, which not only enhances the power factor in the intermediate–low temperature range but also reduces electronic thermal conductivity for decreasing the carrier concentration. On the other hand, CoSi nanoparticles intensively disrupt the phonon transport, hiding the increased lattice thermal conductivity due to reduced Yb filling fraction. Although the residual YbSb2 second phases have an adverse effect on the thermoelectric properties, the integration effects achieve a peak ZT value of 1.37 at 823 K and increase ZTave by 21% for the Yb0.3Co4Sb12/0.1Si sample

Heterogeneous impacts of the scandal on the Baidu search index.

Heterogeneous impacts of the scandal on the Baidu search index.</p

S4 Data -

Widespread vaccination against important diseases plays a key role for global health security, particularly in the context of the COVID-19 pandemic. However, building and maintaining trust in immunization services remains challenging because of doubts about quality and safety of vaccines. China has periodically faced mounting pressure and even public outrage triggered by incidents of poor-quality vaccines. We aimed to evaluate the impact of the diphtheria, pertussis, and tetanus (DPT) vaccine scandal of 2018 in China and the ensuing misinformation on vaccination, and investigate differential responses to the scandal by ethnic and socioeconomic factors. With data from January 2017 to December 2018 in Sichuan province, China, we used a difference-in-differences (DID) method to compare the changes in the county-level monthly DPT vaccinations against the hepatitis B vaccinations, both before and after the DPT vaccine scandal. We found that the number of DPT vaccinations decreased by 14.0 percent in response to the vaccine scandal and ensuing misinformation. The number of vaccinations in minority regions, under-developed regions, and regions with poor medical resources decreased more than in non-minority regions, developed regions, and regions with good medical resources (24.5 versus 10.1 percent, 17.3 versus 8.3 percent, and 17.0 versus 8.7 percent, respectively). People did more online searching for “Substandard vaccine” and “DPT vaccine” after the scandal, with the socioeconomically advantaged group searching more compared with the socioeconomically disadvantaged group. The results suggest the urgent need to make true information about the vaccine easily accessible over the internet, especially for the socioeconomically disadvantaged groups. Our findings for China can also have implications for immunization service planning for better safeguarding public health in other countries, particularly developing ones.</div