Phosphine-Mediated Regio- and Stereoselective Hydrocarboxylation of Enynes

A phosphine-mediated regio- and stereoselective addition reaction of diverse nucleophiles to yne-enones leading to polysubstituted 1,3-diene scaffolds in moderate to good yields has been reported

Phosphine-Mediated Regio- and Stereoselective Hydrocarboxylation of Enynes

A phosphine-mediated regio- and stereoselective addition reaction of diverse nucleophiles to yne-enones leading to polysubstituted 1,3-diene scaffolds in moderate to good yields has been reported

The value of squamous cell carcinoma antigen (SCCa) to determine the lymph nodal metastasis in cervical cancer: A meta-analysis and literature review

<div><p>Background</p><p>The diagnostic power of CT or MRI on the lymph node status was limited. Supplement measurements were needed to assist the diagnosis of lymph node metastasis. The SCCa was reported to be close related to lymph node status. But currently the clinical value of serum SCCa measurement in lymph node status has not been clearly defined. This meta-analysis was to investigate this topic on a large scale.</p><p>Method</p><p>Searching the Pubmed, Embase, Cochrane library, CNKI and Wanfang database for SCC-Ag/SCCA/SCC-antigen and cervical cancer/tumor/carcinoma/neoplasm published in any language from Jan 1 1990 to Aug 1 2017. QUADAS (quality assessment of diagnostic accuracy studies) was used to evaluate the quality of the articles. An eligible set of data should include true positive, true negative, false positive and false negative number. Every set of data was extracted and analyzed by STATA 14.0. The forest plot and bivariate boxplot were utilized to evaluate the heterogeneity. The funnel graph was used to test the publication bias. The SROC curve was draw via random effect model and HSROC model.</p><p>Result</p><p>17 sets of data and 3985 patients were included for the diagnostic meta-analysis. There was heterogeneity, which was partially from SCCa cut-off value. The pooled sensitivity was 0.70 and specificity was 0.63. AUC was 0.73. Eight articles provided the relative risk value of lymphatic metastasis when SCCa increased. The relative risk of lymph node metastasis increased ranging from 2.3–40 as with different SCCa cut off value.</p><p>Conclusion</p><p>The diagnostic value of SCCa for lymph nodal metastasis was medium and it was strongly related to lymph node status. Thus SCCa could assist imaging tests to detect lymph node metastasis. Besides, it was correlated with para-aortic lymph node metastasis.</p></div

sj-xlsx-1-dhj-10.1177_20552076231203801 - Supplemental material for Psychometric evaluation of the Chinese version of the media Health Literacy Questionnaire: A validation study

Supplemental material, sj-xlsx-1-dhj-10.1177_20552076231203801 for Psychometric evaluation of the Chinese version of the media Health Literacy Questionnaire: A validation study by Wenbo Li, Yanli Zhang, Jiaqing Liang and Hongyu Yu in DIGITAL HEALTH</p

The bivariate boxplot about the heterogeneity was drawn.

<p>It demonstrated that 3 sets of data were out of the circles, which indicated there was heterogeneity between articles we included.</p

sj-docx-2-dhj-10.1177_20552076231203801 - Supplemental material for Psychometric evaluation of the Chinese version of the media Health Literacy Questionnaire: A validation study

Supplemental material, sj-docx-2-dhj-10.1177_20552076231203801 for Psychometric evaluation of the Chinese version of the media Health Literacy Questionnaire: A validation study by Wenbo Li, Yanli Zhang, Jiaqing Liang and Hongyu Yu in DIGITAL HEALTH</p

SROC curve was drawn in this meta-analysis.

<p>The random effect model was used via bivariate model (Fig 4A) and HSROC model (Fig 4B). The pooled sensitivity and specificity were 0.70 and 0.63 respectively. AUC was 0.73 indicating a medium diagnostic value.</p

The PRISMA flow diagram of literature screening.

<p>13 articles meet the inclusion and exclusion requirement eventually and were eligible for the meta-analysis.</p

The articles which provided the information about the relationship between the elevated SCCa and the risk of pelvic nodal metastasis.

<p>The articles which provided the information about the relationship between the elevated SCCa and the risk of pelvic nodal metastasis.</p

The results of quality evaluation of QUADAS.

<p>The results of quality evaluation of QUADAS.</p