Shinjulactone O, a new quassinoid from the root bark of <i>Ailanthus altissima</i>

<div><p>A new quassinoid, shinjulactone O (<b>1</b>), and seven known quassinoids, were isolated from the 50% ethanol extract of the root bark of <i>Ailanthus altissima</i>. The structures of these compounds were determined based on spectroscopic methods including UV, IR, HR-ESI-MS, 1D and 2D NMR. Their cytotoxic activities were evaluated on the tumour cell lines MCF-7, MDA-MB-231, HepG2 and A549 cells, as well as the normal HUVEC line <i>in vitro</i>. Compounds <b>1</b>–<b>8</b> exhibited different levels of inhibitory activity against tumour cell lines.</p></div

A new taraxastane-type triterpenoid glycoside from the roots of <i>Clematis uncinata</i>

<div><p></p><p>A new taraxastane-type triterpenoid glycoside, clematiunicinoside I (<b>1</b>), together with four known ones (<b>2–5</b>), was isolated from the roots of <i>Clematis uncinata</i>. The structure of the new compound was elucidated on the basis of spectroscopic analyses and acid hydrolysis. The cytotoxic activities of all the compounds against caski cervical cancer (Caski) cells were evaluated. This is the first report of the presence of taraxastane-type triterpenoid glycoside in the genus <i>Clematis</i>.</p></div

Clerodane Diterpenoids from <i>Croton crassifolius</i>

Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex virus type 1 using the cytopathic effect reduction assay

Clerodane Diterpenoids from <i>Croton crassifolius</i>

Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex virus type 1 using the cytopathic effect reduction assay

Xanthchrysones A–C: Rearranged Phenylpropanoyl–Phloroglucinol Dimers with Unusual Skeletons from Xanthostemon chrysanthus

Three pairs of dimeric phenylpropanoyl–phloroglucinol enantiomers, (+)- and (−)-xanthchrysones A–C [(+)- and (−)-1–3], as well as their postulated biosynthetic precursors, were isolated and identified from the leaves of Xanthostemon chrysanthus. Compound 1 featured an unprecedented bis-phenylpropanoyl-benzo­[b]­cyclopent­[e] oxepine tricyclic backbone. Compounds 2 and 3 represent the first examples of 1-(cyclopentylmethyl)-3-(3-phenylpropanoyl)­benzene scaffold. The structures and absolute configurations of 1–3 were determined by spectroscopic and X-ray diffraction analysis as well as electronic circular dichroism (ECD) calculation. Both (+)-2 and (−)-2 showed moderate antibacterial activities including several multidrug-resistant strains

Clerodane Diterpenoids from <i>Croton crassifolius</i>

Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex virus type 1 using the cytopathic effect reduction assay

Xanthchrysones A–C: Rearranged Phenylpropanoyl–Phloroglucinol Dimers with Unusual Skeletons from Xanthostemon chrysanthus

Three pairs of dimeric phenylpropanoyl–phloroglucinol enantiomers, (+)- and (−)-xanthchrysones A–C [(+)- and (−)-1–3], as well as their postulated biosynthetic precursors, were isolated and identified from the leaves of Xanthostemon chrysanthus. Compound 1 featured an unprecedented bis-phenylpropanoyl-benzo­[b]­cyclopent­[e] oxepine tricyclic backbone. Compounds 2 and 3 represent the first examples of 1-(cyclopentylmethyl)-3-(3-phenylpropanoyl)­benzene scaffold. The structures and absolute configurations of 1–3 were determined by spectroscopic and X-ray diffraction analysis as well as electronic circular dichroism (ECD) calculation. Both (+)-2 and (−)-2 showed moderate antibacterial activities including several multidrug-resistant strains

Clerodane Diterpenoids from <i>Croton crassifolius</i>

Seven new clerodane diterpenoids (<b>1</b>–<b>7</b>) were isolated from roots of <i>Croton crassifolius</i>, along with six known compounds. The structures were elucidated by extensive spectroscopic methods (IR, UV, HRESIMS, 1D NMR, and 2D NMR), and the structures of <b>1</b>, <b>3</b>, <b>4</b>, and <b>7</b> were confirmed by single-crystal X-ray diffraction analyses. Compounds <b>1</b>–<b>13</b> were evaluated for in vitro antiviral activity against herpes simplex virus type 1 using the cytopathic effect reduction assay

Tautomeric cinnamoylphloroglucinol-monoterpene adducts from <i>Cleistocalyx operculatus</i> and their antiviral activities

Guided by 1H NMR spectroscopic experiments using the characteristic enol proton signals as probes, three pairs of new tautomeric cinnamoylphloroglucinol-monoterpene adducts (1–3) were isolated from the buds of Cleistocalyx operculatus. Their structures with absolute configurations were established by spectroscopic analysis, modified Mosher’s method, and quantum chemical electronic circular dichroism calculation. Compounds 1–3 represent a novel class of cinnamoylphloroglucinol-monoterpene adducts featuring an unusual C-4–C-1′ linkage between 2,2,4-trimethyl-cinnamyl-β-triketone and modified linear monoterpenoid motifs. Notably, compounds 1–3 exhibited significant in vitro antiviral activity against respiratory syncytial virus (RSV).</p