Asymmetric Addition of Trimethylsilyl Cyanide to Benzaldehydes Catalyzed by Samarium(III) Chloride and Chiral Phosphorus(V) Reagents

Asymmetric Addition of Trimethylsilyl Cyanide to Benzaldehydes Catalyzed by Samarium(III) Chloride and Chiral Phosphorus(V) Reagent

DH-PS elicited the productions of cytokines and chemokines in human CD14⁺cells.

<p>Human CD14⁺cells isolated from three healthy donors were cultured (1×10⁶ cells/ml) with DH-PS (50 μg/ml) or PBS as control for 18 hrs. Supernatants were harvested for the measurements of cytokines and chemokines. Y-axis represented the mean concentrations (Conc.) of cytokines/chemokines with error bars showing the standard deviation of triplicate. Statistically significant difference: * compared with PBS-treated group, p<0.05. # compared with PBS-treated group, p<0.005.</p

DH-PS elicited the productions of cytokines and chemokines in human peripheral blood mononuclear cells (PBMC).

<p>Human PBMCs isolated from three healthy donors were cultured (2×10⁶ cells/ml) with DH-PS (50 μg/ml) or PBS as control for 18 hrs. Supernatants were harvested for the measurements of cytokines and chemokines. Y-axis represented the mean concentrations (Conc.) of cytokines/chemokines with error bars showing the standard deviation of triplicate. Statistically significant difference: * compared with PBS-treated group, p<0.05. # compared with PBS-treated group, p<0.005.</p

Construction of Cd/Zn(II)-1,2,4-Triazolate Coordination Complexes via Changing Substituents and Anions

A series of zero- to three-dimensional Cd/Zn(II)-1,2,4-triazolate coordination complexes have been obtained by changing the anions and the substituents on the triazole ring. Cd2(2-pytrz)2Cl4 (1) and Cd3(dpatrz)4Cl6 (2) (2-pytrz = 3,5-di(pyrid-2-yl)-1,2,4-triazole and dpatrz = 3,5-di(n-propyl)-4-amino- 1,2,4-triazole) have discrete binuclear and trinuclear structures, respectively. Cd3(atrz)4Cl6 (3) and Cd(atrz)2(SCN)2 (4) (atrz = 4-amino-1,2,4-triazole) are polymeric 1D chains constructed from trinuclear cadmium units and mononuclear cores. Cd(datrz)I (5), Zn(dmtrz)Cl (6), and Cd3(dmatrz)4(N3)6 (7) (datrz = 3,5-diamino-1,2,4-triazole, dmtrz = 3,5-dimethyl-1,2,4-triazole, and dmatrz = 3,5-dimethyl-4-amino-1,2,4-triazole) all show two-dimensional layer structures. Complexes 5 and 6 are 2D grids based on binuclear clusters and present (4.82)metal(4.82)trz topology. Complex 7 is of 2D (4,4) topology when trinuclear cadmium units are regarded as four-connected nodes. For complexes 1−7, weak hydrogen-bonding contacts link the discrete polynuclear clusters, 1D chains, or 2D layers to form three-dimensional supramolecular structures. Zn2(trz)3Cl (8) (trz = 1,2,4-triazole) presents an interesting 3D network based on three nonequivalent nodes and has a (46861224)(861254)(42841236)3 topology. Complexes 1−8 all exhibit strong blue fluorescence emission bands in the solid state at ambient temperature

Design of Novel Three-Dimensional Coordination Polymers Based on Triangular Trinuclear Copper 1,2,4-Triazolate Units

By controlling the molar ratios of copper dichloride dihydrate and 1,2,4-triazole (trz), we generated a series of novel three-dimensional coordination polymers constructed from μ3-oxo or μ3-Cl triangular copper units, exhibiting six-connected porous self-penetrating net, graphite layer, and inorganic−organic hybrid network structures, respectively

Construction of Cd/Zn(II)-1,2,4-Triazolate Coordination Complexes via Changing Substituents and Anions

A series of zero- to three-dimensional Cd/Zn(II)-1,2,4-triazolate coordination complexes have been obtained by changing the anions and the substituents on the triazole ring. Cd2(2-pytrz)2Cl4 (1) and Cd3(dpatrz)4Cl6 (2) (2-pytrz = 3,5-di(pyrid-2-yl)-1,2,4-triazole and dpatrz = 3,5-di(n-propyl)-4-amino- 1,2,4-triazole) have discrete binuclear and trinuclear structures, respectively. Cd3(atrz)4Cl6 (3) and Cd(atrz)2(SCN)2 (4) (atrz = 4-amino-1,2,4-triazole) are polymeric 1D chains constructed from trinuclear cadmium units and mononuclear cores. Cd(datrz)I (5), Zn(dmtrz)Cl (6), and Cd3(dmatrz)4(N3)6 (7) (datrz = 3,5-diamino-1,2,4-triazole, dmtrz = 3,5-dimethyl-1,2,4-triazole, and dmatrz = 3,5-dimethyl-4-amino-1,2,4-triazole) all show two-dimensional layer structures. Complexes 5 and 6 are 2D grids based on binuclear clusters and present (4.82)metal(4.82)trz topology. Complex 7 is of 2D (4,4) topology when trinuclear cadmium units are regarded as four-connected nodes. For complexes 1−7, weak hydrogen-bonding contacts link the discrete polynuclear clusters, 1D chains, or 2D layers to form three-dimensional supramolecular structures. Zn2(trz)3Cl (8) (trz = 1,2,4-triazole) presents an interesting 3D network based on three nonequivalent nodes and has a (46861224)(861254)(42841236)3 topology. Complexes 1−8 all exhibit strong blue fluorescence emission bands in the solid state at ambient temperature

DH-PS induced IL-1ra production <i>in vivo</i>.

<p>BALB/c mice (n = 3 for each group) were injected intraperitoneally with DH-PS (100 or 300 μg/mouse) or PBS only. Sera collected at 0 (before injection), 2 and 18 hours were used for the measurements of IL-1ra by ELISA assay. Results were presented as mean concentrations with error bars showing the standard deviation of three mice. Statistically significant difference: * compared with PBS-treated group, p<0.05.</p

DH-PS expanded subpopulations of splenocytes.

<p>BALB/c mice (n = 3 for DH-PS and PBS group) were injected intraperitoneally with DH-PS (100 μg or 300 μg) or PBS only (DH-PS  = 0) and sacrificed at 72 hrs for the harvest of splenocytes. Cell populations were characterized by the following markers: NK cells (NK-1.1⁺CD3⁻), activated NK cells (NK-1.1⁺CD3⁻CD69⁺), NKT cells (NK-1.1⁺CD3⁺), activated NKT cells (NK-1.1⁺CD3⁺CD69⁺), regulatory T cells (CD4⁺CD25⁺FOXP3⁺), granulocytes (Ly6G⁺), monocytes and macrophages (CD11b⁺), dendritic cells (CD11c⁺), activated dendritic cells (CD11C⁺CD80⁺CD86⁺), B cells (B220⁺CD23⁺), activated B cells (B220⁺CD23⁺CD69⁺), CD4⁺ T cells (CD3⁺CD4+), activated CD4⁺ T cells (CD3⁺CD4⁺CD69⁺), CD8⁺ T cells (CD3⁺CD8⁺) and activated CD8⁺ T cells (CD3⁺CD8⁺CD69⁺). Results were presented as mean values with error bars showing the standard deviation of three mice. Results were converted to log value before the determination of statistical significance. Statistically significant difference: * compared with PBS-treated group, p<0.05. # compared with PBS-treated group, p<0.01.</p

Construction of Cd/Zn(II)-1,2,4-Triazolate Coordination Complexes via Changing Substituents and Anions

A series of zero- to three-dimensional Cd/Zn(II)-1,2,4-triazolate coordination complexes have been obtained by changing the anions and the substituents on the triazole ring. Cd2(2-pytrz)2Cl4 (1) and Cd3(dpatrz)4Cl6 (2) (2-pytrz = 3,5-di(pyrid-2-yl)-1,2,4-triazole and dpatrz = 3,5-di(n-propyl)-4-amino- 1,2,4-triazole) have discrete binuclear and trinuclear structures, respectively. Cd3(atrz)4Cl6 (3) and Cd(atrz)2(SCN)2 (4) (atrz = 4-amino-1,2,4-triazole) are polymeric 1D chains constructed from trinuclear cadmium units and mononuclear cores. Cd(datrz)I (5), Zn(dmtrz)Cl (6), and Cd3(dmatrz)4(N3)6 (7) (datrz = 3,5-diamino-1,2,4-triazole, dmtrz = 3,5-dimethyl-1,2,4-triazole, and dmatrz = 3,5-dimethyl-4-amino-1,2,4-triazole) all show two-dimensional layer structures. Complexes 5 and 6 are 2D grids based on binuclear clusters and present (4.82)metal(4.82)trz topology. Complex 7 is of 2D (4,4) topology when trinuclear cadmium units are regarded as four-connected nodes. For complexes 1−7, weak hydrogen-bonding contacts link the discrete polynuclear clusters, 1D chains, or 2D layers to form three-dimensional supramolecular structures. Zn2(trz)3Cl (8) (trz = 1,2,4-triazole) presents an interesting 3D network based on three nonequivalent nodes and has a (46861224)(861254)(42841236)3 topology. Complexes 1−8 all exhibit strong blue fluorescence emission bands in the solid state at ambient temperature

Construction of Cd/Zn(II)-1,2,4-Triazolate Coordination Complexes via Changing Substituents and Anions

A series of zero- to three-dimensional Cd/Zn(II)-1,2,4-triazolate coordination complexes have been obtained by changing the anions and the substituents on the triazole ring. Cd2(2-pytrz)2Cl4 (1) and Cd3(dpatrz)4Cl6 (2) (2-pytrz = 3,5-di(pyrid-2-yl)-1,2,4-triazole and dpatrz = 3,5-di(n-propyl)-4-amino- 1,2,4-triazole) have discrete binuclear and trinuclear structures, respectively. Cd3(atrz)4Cl6 (3) and Cd(atrz)2(SCN)2 (4) (atrz = 4-amino-1,2,4-triazole) are polymeric 1D chains constructed from trinuclear cadmium units and mononuclear cores. Cd(datrz)I (5), Zn(dmtrz)Cl (6), and Cd3(dmatrz)4(N3)6 (7) (datrz = 3,5-diamino-1,2,4-triazole, dmtrz = 3,5-dimethyl-1,2,4-triazole, and dmatrz = 3,5-dimethyl-4-amino-1,2,4-triazole) all show two-dimensional layer structures. Complexes 5 and 6 are 2D grids based on binuclear clusters and present (4.82)metal(4.82)trz topology. Complex 7 is of 2D (4,4) topology when trinuclear cadmium units are regarded as four-connected nodes. For complexes 1−7, weak hydrogen-bonding contacts link the discrete polynuclear clusters, 1D chains, or 2D layers to form three-dimensional supramolecular structures. Zn2(trz)3Cl (8) (trz = 1,2,4-triazole) presents an interesting 3D network based on three nonequivalent nodes and has a (46861224)(861254)(42841236)3 topology. Complexes 1−8 all exhibit strong blue fluorescence emission bands in the solid state at ambient temperature