Cannabinoids help to unravel etiological aspects in common and bring hope for the treatment of autism and epilepsy

Desde 1843 que as propriedades anticonvulsivantes da Cannabis são conhecidas pela ciência ocidental. Em 1980, ensaios clínicos demonstraram que canabidiol possui atividade antiepilética em pacientes de epilepsia refratária, sendo sonolência o único efeito colateral. O embargo imposto pela proibição do uso medicinal da Cannabis, no entanto, prejudicou imensamente o desenvolvimento científico e a exploração dessas propriedades. Multiplicam-se, contudo, os casos bem sucedidos de uso ilegal e sem orientação para o tratamento de síndromes caracterizadas por epilepsia e autismo regressivo. Os resultados corroboram evidências científicas que indicam a existência de processos etiológicos comuns entre o autismo e a epilepsia. Estudos em modelos animais confirmam envolvimento do sistema endocanabinoide. Esses avanços apontam o início de uma revolução no entendimento e tratamento desses transtornos.Since 1843 the anticonvulsant properties of Cannabis are known by the Western science. In 1980, clinical trials have shown that cannabidiol has antiepileptic activity in refractory epilepsy patients, with drowsiness as the only side effect. The embargo imposed by banning medicinal Cannabis use, however, harmed scientific development and the exploration of these properties. However, there is a growing number of successful cases of illegal use without guidance for the treatment of syndromes characterized by epilepsy and regressive autism. The results corroborate scientific evidence that indicates the existence of common etiological aspects between autism and epilepsy. Studies in animal models have confirmed involvement of the endocannabinoid system. These advances indicate the beginning of a revolution in the understanding and treatment of these disorders

Kenya: West Kenya postmarks

HiWATER: The Multi-Scale Observation Experiment on Evapotranspiration over heterogeneous land surfaces (MUSOEXE) Dataset - Flux Observation Matrix (stable isotopic observations

The time-depth of Corded Ware burial landscapes: A comparative study of Single Grave and Battle Axe burial alignments in Denmark, The Netherlands and Sweden

Barrow landscapes appeared in the third and second millennia BC throughout North-Western Europe; these first barrows were constructed by people of the Corded Ware culture and placed in alignments. This thesis is an interregional comparative study, to determine whether there is a pattern in the time-depths of the burial alignments of Trehuse-Sjørup-Dollerup in Denmark, Angelso-Emmerhout in The Netherlands and Lilla Beddinge in Sweden. The analysis is conducted by means of a literature study and the application of typochronologies. In recent research, the Corded Ware ‘culture’ is still seen as a widespread, unified social phenomenon that is the result of migration, but more emphasis is placed on the regional variability of this phenomenon. Regional variability is also what we see in the three case-studies; in fact, perhaps one may better speak of ‘local variability’, as each case-study reveals a remarkable variety even within one alignment. Even though there do seem to be interregionally shared traits, these are expressed in local practices. Despite the limitations of establishing a time-depth by means of typochronologies, all three alignments reveal a long use-life; even in the Bronze and Iron Ages, prehistoric people buried their dead here. Temporality seems to have been an important aspect of the ‘Corded Ware’ burial landscape

Collaborative mental health care : changing the landscape of mental health care?

In this thesis two major changes in the organization of mental health care delivery are explored. The first is collaborative mental health care in primary care, developed as an alternative way to treat common mental health disorders compared to the traditional referral and treatment practice. The collaborative care program followed the principles of stepped care. The first and least intensive treatment step was provided within the collaborative care program in the primary care setting. Treatment intensity was only stepped up through referral to specialized mental health care for patients who did not sufficiently respond to the first step. The traditional practice was direct referral and treatment within specialized care. In several studies we investigated effectiveness, short- and long-term efficiency, cost-effectiveness and whether the stepped care approach was appropriate for all patients instead of the matched care approach. The second change was the integration of eHealth in the collaborative care treatment model. In this study, implementation factors that could either inhibit or promote the uptake and utilization of blended collaborative care by mental health professionals and patients were assessed

First report of <i>Neofusicoccum parvum</i> causing leaf target-spot disease on <i>Ficus carica</i> L. in China

Figs (Ficus carica L.) are widely cultivated throughout the world owing to their excellent medical and edible value. In October 2021, we discovered a new leaf target-spot disease associated with the common fig in China. It is necessary to identify the causal agent, as it seriously affects the normal growth of figs and reduces their economic value. The initially infected leaves displayed light yellow lesions between the leaf veins. Under conditions of suitable temperature and humidity, the lesions expanded rapidly with light brown in the middle and dark brown at the margin accompanied by a yellow halo, and typical target holes appeared in the centre of the lesions. Three filamentous fungi were isolated from infected leaves, among which the isolate WHG-3 exerted the strongest virulence in vitro. Its newly grown mycelia were white and then gradually turned to dark grey. The conidia were hyaline, spindle-shaped or oval, with thin cell walls. Phylogenetic analyses based on the ITS, tef-1 and tub2 gene sequences verified that the isolates WHG-3, WHG-4 and WHG-5 were Neofusicoccum parvum. To the best of our knowledge, this is the first report that N. parvum causes leaf target-spot on Ficus carica L. in China.</p

Interannual variation in lake areas over 50 km² on the Tibetan Plateau from 1986 to 2020 based on remote sensing big data

Lake distribution on the Tibetan Plateau (TP) is extensive, and lake area changes are key indicators of the TP's climate change response. Many multisource remote sensing big data for the TP, particularly optical images, are unusable due to cloud cover. Therefore, an improved isobath interpolation-based lake area extraction method is proposed and applied to obtain annual average lake areas (≥ 50 km²) on the TP from 1986 to 2020 using remote sensing big data. The lake area result accuracy was verified using existing lake area and level datasets, yielding correlation coefficients of ∼0.9. The change points and segmented trends of each lake's interannual area sequence were obtained. The relationships between lake area and climatic variables were investigated. The positive accumulation of the total precipitation minus total evaporation explains the overall lake area expansion trend after 1995. The exorheic lake interannual area is related to precipitation more than that of endorheic lakes, but endorheic lake area changes are stronger. The shrinking of lakes on the southern TP may not be climate-driven but probably attributed to lake bottom leakage. We explore detailed interannual variation characteristics of lake areas on the TP and provide reference data for studying lake responses to climate change.</p

Additional file 1 of Genome-wide identification and expression patterns of the laccase gene family in response to kiwifruit bacterial canker infection

Additional file 1: Table S1. Basic physical and chemical characteristics and putative subcellular localization of the proteins encoded by AcLACs

HiWATER: Dataset of airborne microwave radiometers (L bands) mission along the riverway of Heihe River in the middle reaches of the Heihe River Basin on 3 July, 2012

HiWATER: Dataset of airborne microwave radiometers (L bands) mission along the riverway of Heihe River in the middle reaches of the Heihe River Basin on 3 July, 201

HiWATER: Dataset of thermal infrared spectrum observed by BOMEM MR304 in the middle reaches of the Heihe River Basin

HiWATER: Dataset of thermal infrared spectrum observed by BOMEM MR304 in the middle reaches of the Heihe River Basi

HiWATER: Dataset of vegetation LAI measured by LAI2000 in the middle reaches of the Heihe River Basin

HiWATER: Dataset of vegetation LAI measured by LAI2000 in the middle reaches of the Heihe River Basi