Mr Upjohn’s Debts: Money and Friendship in Early Colonial Calcutta

The paper discusses the effective operation of money and credit among Europeans in Calcutta around 1800, arguing for the importance of informal processes and ties of friendship that facilitated, regulated and enforced agreements, helping both to tide over individuals in times of economic stress and to underwrite the provision and transfer of capital. The argument is advanced by a detailed case study in regard to debts owed by one resident, Aaron Upjohn, to another, Richard Blechynden, amidst a web of acquaintance, officialdom and law that variously ensured that the debts were honoured. It is defined as ‘a support system among acquaintances, necessitated in part by shortage of money and abundance of risk’

Classroom contexts for learning at primary and secondary school: Class size, groupings, interactions and special educational needs

The inclusion of pupils with special educational needs and disabilities (SEND) in mainstream schools can result in difficult decisions regarding classroom organisation and management. The premise of this article is that these are likely to be affected by the classroom context, specifically the number of pupils in the class, the size and composition of groups and classes, and the presence of additional adults, but that there is very little systematic information on these features. A systematic observation study was conducted involving 48 pupils at Year 5 (9–10 years) and 49 pupils at Year 9 (13–14 years) with Statements of SEND, along with 115 comparison pupils at Year 5 and 112 at Year 9 who were typically developing. There were nearly 70,000 observations (data points) in total. Results showed that pupils at Year 5 with SEN were being taught in larger classes than at Year 9, and that, compared with typically developing pupils, they were much more likely to be separately taught in small, low‐attaining groups at Year 5 and small, low‐attaining classes (sets) at secondary. The study raises worrying questions about the appropriateness of classroom contexts for pupils with SEND and the heavy reliance on teaching assistants

Comparative metagenomics reveals the distinctive adaptive features of the Spongia officinalis endosymbiotic consortium

Current knowledge of sponge microbiome functioning derives mostly from comparative analyses with bacterioplankton communities. We employed a metagenomics-centered approach to unveil the distinct features of the Spongia officinalis endosymbiotic consortium in the context of its two primary environmental vicinities. Microbial metagenomic DNA samples (n = 10) from sponges, seawater, and sediments were subjected to Hiseq Illumina sequencing (c. 15 million 100 bp reads per sample). Totals of 10,272 InterPro (IPR) predicted protein entries and 784 rRNA gene operational taxonomic units (OTUs, 97% cut-off) were uncovered from all metagenomes. Despite the large divergence in microbial community assembly between the surveyed biotopes, the S. officinalis symbiotic community shared slightly greater similarity (p < 0.05), in terms of both taxonomy and function, to sediment than to seawater communities. The vast majority of the dominant S. officinalis symbionts (i.e., OTUs), representing several, so-far uncultivable lineages in diverse bacterial phyla, displayed higher residual abundances in sediments than in seawater. CRISPR-Cas proteins and restriction endonucleases presented much higher frequencies (accompanied by lower viral abundances) in sponges than in the environment. However, several genomic features sharply enriched in the sponge specimens, including eukaryotic-like repeat motifs (ankyrins, tetratricopeptides, WD-40, and leucine-rich repeats), and genes encoding for plasmids, sulfatases, polyketide synthases, type IV secretion proteins, and terpene/terpenoid synthases presented, to varying degrees, higher frequencies in sediments than in seawater. In contrast, much higher abundances of motility and chemotaxis genes were found in sediments and seawater than in sponges. Higher cell and surface densities, sponge cell shedding and particle uptake, and putative chemical signaling processes favoring symbiont persistence in particulate matrices all may act as mechanisms underlying the observed degrees of taxonomic connectivity and functional convergence between sponges and sediments. The reduced frequency of motility and chemotaxis genes in the sponge microbiome reinforces the notion of a prevalent mutualistic mode of living inside the host. This study highlights the S. officinalis "endosymbiome" as a distinct consortium of uncultured prokaryotes displaying a likely "sit-and-wait" strategy to nutrient foraging coupled to sophisticated anti-viral defenses, unique natural product biosynthesis, nutrient utilization and detoxification capacities, and both microbe-microbe and host-microbe gene transfer amenability.Portuguese Foundation for Science and Technology (FCT) [PTDC/BIA-MIC/3865/2012, PTDC/MAR-BIO/1547/2014]; Education, Audiovisual and Culture Executive Agency (European Commission, Erasmus Mundus Programme) [EMA2 lot7/SALA1206422]info:eu-repo/semantics/publishedVersio

Systematic review of non-custodial employment programs: Impact on recidivism rates of ex-offenders

Background: Over the last 25 years, many programs that were designed to increase employment for persons with a criminal history have been implemented and evaluated. The implicit, and often explicit, intent of these programs has been to reduce recidivism. Wilson et al. (1999, 2000) conducted a quantitative synthesis of 33 evaluations of educational, vocational, and work programs for persons in correctional facilities. To date, however, the evaluation literature on employment services programs for those with a recent criminal record who are not in custody has not been systematically reviewed. Objectives: To assess the effects of programs designed to increase employment through job training and/or job placement among formerly incarcerated persons (i.e., those recently released), aimed at improving employment and reducing recidivism. Search Strategy: Searches of literature reviews by the first author were augmented by structured searches of nine electronic data bases, including the Campbell SPECTR database of trials to identify random assignment studies conducted after 1970. Experts in the field were consulted and relevant citations were followed up. Selection Criteria: Selecting studies based on the original objective – to examine employment services interventions for recently released prisoners – did not produce a sufficient number of studies for analysis. Thus, the selection criteria were expanded to include studies that tested the effects of job training or job placement programs or both for persons who had been arrested, convicted or incarcerated in connection with a criminal charge. Only random assignment studies of adults or studies that combined older youth (ages 16-17) and adults were included. If the treatment or comparison groups included subjects who were not ex-offenders, the results must have been reported separately for the ex-offenders. Data Collection and Analysis: We report narratively on the eight eligible studies. More than 6,000 older youth (aged 16-17) and adults with prior contact with the criminal justice system participated in these studies. Two studies contributed two independent effect sizes for a total of ten effect sizes for the eight studies. We used arrests during the follow-up period (typically, 12 months) as the outcome measure. We ran three analyses: one with a mixture of dichotomized and continuous arrest measures, a second with logged odds ratio effect sizes, and a third splitting the sample into those with a conviction and those without a conviction. Main Results: The analyses show that employment-focused interventions for ex-offenders in these studies did not reduce recidivism, although this group of random assignment studies is highly heterogeneous both in the type of employment program delivered and the individuals enrolled in the program. Thus, the results should not be generalized to former prisoners who are enrolled in employment programs after release. The studies are also mostly out of date and the average subject was not typical of persons released from prison in the U.S. in the early 2000s. Reviewers’ Conclusions: We conclude that employment-focused interventions for former prisoners have not been adequately evaluated for their effectiveness using random assignment designs. After broadening the selection criteria to include individuals with criminal records, only eight studies, the majority of which are more than 10 years old, could be identified. Nonetheless, overall, the eight interventions had no significant effect on the likelihood that participants would be rearrested. Many employment-focused interventions for ex-offenders are being implemented. A new generation of rigorous evaluations is needed to provide direction to policymakers as to the most effective combination of employment-related services for specific types of ex-offenders

Feasibility of implementing a rapid-learning methodology to inform radiotherapy treatments: key professional stakeholders’ views

Objective Pragmatic methodologies, often termed rapid-learning, are being pursued that can match the pace of innovation in radiotherapy and generate evidence from the real-world treatment setting. It is important to understand the feasibility of implementing such pragmatic approaches before their application in practice. This study investigated key professional stakeholders’ perceptions and opinions of rapid-learning and real-world data (RWD). Methods and analysis Twenty-three interviews were conducted with key professional stakeholders based across five UK radiotherapy cancer centres. Centres varied in size and reflected different healthcare environments. Data were collected between December 2022 and May 2023, and analysed using inductive thematic analysis. Results Four themes were generated: (1) the alignment of rapid-learning methodologies with the reality of practice, (2) concerns related to the variability of RWD, (3) the maturity of data infrastructures and capacity for rapid-learning and (4) further support, education and evidence needed to convince stakeholders to adopt rapid-learning approaches. Conclusion The potential of rapid-learning to help address evidence gaps in radiotherapy development was positively received by different professional stakeholders. However, the effectiveness of rapid-learning was viewed as being highly dependent on the collection of quality data in the routine setting, while the variable set-up at different cancer centres is also likely to be a key challenge for potential implementation. Developing data infrastructures to improve data interoperability was considered crucial for rapid-learning implementation, along with method clarity, educational support and training for radiotherapy teams

Non-Instrumental Movement Inhibition (NIMI) differentially suppresses head and thigh movements during screenic engagement: dependence on interaction

BACKGROUND: Estimating engagement levels from postural micromovements has been summarized by some researchers as: increased proximity to the screen is a marker for engagement, while increased postural movement is a signal for disengagement or negative affect. However, these findings are inconclusive: the movement hypothesis challenges other findings of dyadic interaction in humans, and experiments on the positional hypothesis diverge from it. HYPOTHESES: (1) Under controlled conditions, adding a relevant visual stimulus to an auditory stimulus will preferentially result in Non-Instrumental Movement Inhibition (NIMI) of the head. (2) When instrumental movements are eliminated and computer-interaction rate is held constant, for two identically-structured stimuli, cognitive engagement (i.e., interest) will result in measurable NIMI of the body generally. METHODS: Twenty-seven healthy participants were seated in front of a computer monitor and speakers. Discrete 3-min stimuli were presented with interactions mediated via a handheld trackball without any keyboard, to minimize instrumental movements of the participant's body. Music videos and audio-only music were used to test hypothesis (1). Time-sensitive, highly interactive stimuli were used to test hypothesis (2). Subjective responses were assessed via visual analog scales. The computer users' movements were quantified using video motion tracking from the lateral aspect. Repeated measures ANOVAs with Tukey post hoc comparisons were performed. RESULTS: For two equivalently-engaging music videos, eliminating the visual content elicited significantly increased non-instrumental movements of the head (while also decreasing subjective engagement); a highly engaging user-selected piece of favorite music led to further increased non-instrumental movement. For two comparable reading tasks, the more engaging reading significantly inhibited (42%) movement of the head and thigh; however, when a highly engaging video game was compared to the boring reading, even though the reading task and the game had similar levels of interaction (trackball clicks), only thigh movement was significantly inhibited, not head movement. CONCLUSIONS: NIMI can be elicited by adding a relevant visual accompaniment to an audio-only stimulus or by making a stimulus cognitively engaging. However, these results presume that all other factors are held constant, because total movement rates can be affected by cognitive engagement, instrumental movements, visual requirements, and the time-sensitivity of the stimulus

Understanding a language of ‘aristocracy’, 1700-1850

This article engages with current debates about linguistic usage but in a new way. It examines linguistic change, the shifts in frequency of usage of ‘aristocracy,’ both qualitatively and quantitatively, at specific moments and over time, in print of the period 1700 to 1850. Digital resources are utilized to provide broad quantitative evidence not previously available to historians. The potential use and value of digitized sources is also explored in calculating the volume and frequency of keyword appearance within a broad set of genres. This article also examines qualitatively usage of ‘aristocracy’ by contemporaries and historians and concludes that historians have often used the term anachronistically. It reveals that for much of the eighteenth century ‘aristocracy’ was entirely a political term confined primarily to the educated elite but that by 1850 it had become a common social descriptor of an elite class. It also compares the trajectory of usage of ‘aristocracy’ with that of ‘democracy’ and accounts for the divergence in such usage. It is argued here that analyzing the prevalence and usage of ‘aristocracy’ in contemporary contexts reveals an important narrative of linguistic changes that parallel shifts in political and social culture

Re-stating the post-political: depoliticization, social inequalities, and city-region growth

This paper argues that city-region building debates and relatedly ‘post-political’ literatures are missing critical perspectives on the state, particularly the state’s continued existence as a social relation and an arena for politics, its role in the regulation of uneven development and the conflicts and struggles that arise from this. The paper brings the state centrally into ‘post-political’ debates via a critical analysis of the interrelationships between depoliticization and neoliberalism. Focusing on Sheffield (South Yorkshire, England) in the context of devolution and deal-making public policy, the paper explores the seemingly consensual visionmaking dynamics of this city region and dissects the tensions around economic governance, welfare austerity and social inequalities to get a handle on the ‘postpolitical’ depoliticized state in, and of, contemporary capitalism

Developmental changes in human dopamine neurotransmission: cortical receptors and terminators

<p>Abstract</p> <p>Background</p> <p>Dopamine is integral to cognition, learning and memory, and dysfunctions of the frontal cortical dopamine system have been implicated in several developmental neuropsychiatric disorders. The dorsolateral prefrontal cortex (DLPFC) is critical for working memory which does not fully mature until the third decade of life. Few studies have reported on the normal development of the dopamine system in human DLPFC during postnatal life. We assessed pre- and postsynaptic components of the dopamine system including tyrosine hydroxylase, the dopamine receptors (D1, D2 short and D2 long isoforms, D4, D5), catechol-<it>O</it>-methyltransferase, and monoamine oxidase (A and B) in the developing human DLPFC (6 weeks -50 years).</p> <p>Results</p> <p>Gene expression was first analysed by microarray and then by quantitative real-time PCR. Protein expression was analysed by western blot. Protein levels for tyrosine hydroxylase peaked during the first year of life (p < 0.001) then gradually declined to adulthood. Similarly, mRNA levels of dopamine receptors D2S (p < 0.001) and D2L (p = 0.003) isoforms, monoamine oxidase A (p < 0.001) and catechol-<it>O</it>-methyltransferase (p = 0.024) were significantly higher in neonates and infants as was catechol-<it>O</it>-methyltransferase protein (32 kDa, p = 0.027). In contrast, dopamine D1 receptor mRNA correlated positively with age (p = 0.002) and dopamine D1 receptor protein expression increased throughout development (p < 0.001) with adults having the highest D1 protein levels (p ≤ 0.01). Monoamine oxidase B mRNA and protein (p < 0.001) levels also increased significantly throughout development. Interestingly, dopamine D5 receptor mRNA levels negatively correlated with age (r = -0.31, p = 0.018) in an expression profile opposite to that of the dopamine D1 receptor.</p> <p>Conclusions</p> <p>We find distinct developmental changes in key components of the dopamine system in DLPFC over postnatal life. Those genes that are highly expressed during the first year of postnatal life may influence and orchestrate the early development of cortical neural circuitry while genes portraying a pattern of increasing expression with age may indicate a role in DLPFC maturation and attainment of adult levels of cognitive function.</p