857 research outputs found

    Ups & Downs

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    Stone Meets Steel

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    Doesn\u27t Your Work Just Re-Center Whiteness? The Fallen Impossibilities of White Allyship

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    Our purpose is to engage performative dialogue incorporative of currere on a central question in critical White studies (CWS). After precautionary notes and positionalities, we frame our dialogue within second-wave CWS. As its main section, six CWS scholars respond to the central question: Doesn’t research on White identities re-center whiteness? Analyzing the scholars’ responses, the performative dialogue is followed by an analytical discussion of CWS’ epistemological, ontological, and axiological convolutions. Via these convolutions, we recognize the impossibilities of facile “White allyship” within antiracist scholarship, curriculum and pedagogy, and related social movements. Instead of White allyship, we propose situated, relational, and process-oriented notions of alliance-oriented antiracist work

    Toward a Decision Support System for Mitigating Urban Heat

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    With the continuous rise of global urbanization, city planners and policymakers are increasingly concerned with urban heat islands (UHI), which are metropolitan areas that are significantly warmer than their surrounding rural areas. We address the United Nation’s Sustainable Development Goal 11 “Sustainable Cities and Communities,” and we design and develop a decision support system (DSS), which will help city planners and policymakers to overcome economic barriers to reach environmental sustainability goals

    Patient experiences of anxiety, depression and acute pain after surgery: a longitudinal perspective

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    This study sought to explore the impact of the psychological variables anxiety and depression, on pain experience over time following surgery. Eighty-five women having major gynaecological surgery were assessed for anxiety, depression and pain after surgery. To gain further understanding, 37 patients participated in a semi-structured taped telephone interview 4–6 weeks post-operatively. Pre-operative anxiety was found to be predictive of post-operative anxiety on Day 2, with patients who experienced high levels of anxiety before surgery continuing to feel anxious afterwards. By Day 4 both anxiety and depression scores increased as pain increased and one-third of the sample experienced levels of anxiety in psychiatric proportions whilst under one-third experienced similar levels of depression. These findings have significant implications for the provision of acute pain management after surgery. Future research and those managing acute pain services need to consider the multidimensional effect of acute pain and the interface between primary and secondary care

    A human embryonic kidney 293T cell line mutated at the Golgi -mannosidase II locus

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    Disruption of Golgi -mannosidase II activity can result in type II congenital dyserythropoietic anemia and can induce lupus-like autoimmunity in mice. Here, we isolate a mutant human embryonic kidney (HEK) 293T cell line, called Lec36, that displays sensitivity to ricin that lies between the parental HEK 293T cells, whose secreted and membrane-expressed proteins are dominated by complex-type glycosylation, and 293S Lec1 cells, which only produce oligomannose-type N-linked glycans. The stem cell marker, 19A, was transiently expressed in the HEK 293T Lec36 cells, and in parental HEK 293T cells with and without the potent Golgi -mannosidase II inhibitor, swainsonine. Negative-ion nano-electrospray ionization mass spectra of the 19A N-linked glycans from HEK 293T Lec36 and swainsonine-treated HEK 293T cells were qualitatively indistinguishable and, as shown by collision-induced dissociation spectra, dominated by hybrid-type glycosylation. Nucleotide sequencing revealed mutations in each allele of MAN2A1, the gene encoding Golgi -mannosidase II: a point mutation in one allele mapping to the active site and an in-frame deletion of twelve-nucleotides in the other. Expression of wild-type but not the mutant MAN2A1 alleles in Lec36 cells restored processing of the 19A reporter glycoprotein to complex-type glycosylation. The Lec36 cell line will be useful for expressing therapeutic glycoproteins with hybrid-type glycans and provides a sensitive host for detecting mutations in human MAN2A1 causing type II congenital dyserythropoietic anemia

    High-impact firms in South Carolina

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    This study analyzes private-sector firms and employment change in South Carolina from a new perspective. For years, it has been widely believed that small businesses create almost all jobs in the United States. Recent research has suggested that a small number of fast-growing firms (many small and medium-sized) are responsible for a majority of the employment gains in the United States. The research presented in this study assesses the scope of South Carolina’s small-business and high-impact job creation over the past two decades

    The economic impact of South Carolina 's automotive cluster

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    This executive summary highlights the results of an in-depth, comprehensive economic study of South Carolina’s automotive and ground transportation cluster. The study shows that the auto cluster plays a unique role in economic development. Notably, few other sectors of the economy have the real potential to scale up employment, which is the most pressing economic imperative in South Carolina today. Automotive and ground transportation-related businesses contribute to approximately 5.4 percent of the state’s employment base, according to 2008 data compiled by the Division of Research. Importantly, the employment multipliers for each job created in South Carolina are unparalleled. For the automotive-related sectors examined in this study, the job impacts are higher than any other specific sector or industry

    Utilising eDNA methods and interactive data dashboards for managing sustainable drinking water

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    Generating rapid, easy-to-interpret community data for drinking reservoirs as a means of tackling water quality management is of increasing demand within the water industry. Taste and odour (T&O) is one of many increasing concerns to water companies worldwide, incurring huge costs as customer complaints accumulate and additional treatment and resource management are required. However, there remains a two-fold issue in addressing T&O management: firstly, predicting the initial onset of a T&O event relies on a highly complex understanding of environmental considerations and their interaction with T&O-related taxa, and secondly, there remains a lag between the notification of a T&O event and the resolution of the issue by reservoir management staff. This is partly due to slow, low-resolution methods of detecting and reliably identifying problem taxa in samples. These methods are unable to provide information on the huge plethora of taxa related to T&O metabolite production and often cannot provide data in a timely enough manner for an opportune management response. This means the water industry is often forced to use a reactive, rather than proactive, approach to water quality monitoring. Here, we present methods for implementing a high-throughput sequencing approach to monitoring drinking reservoirs for water quality and improving the sustainability of water supplies, as well as methods for presenting these data on easy-to-interpret data dashboards that can be updated rapidly as new data are generated. Our methods and dashboarding approaches are currently being trialled and tested within the UK water industry, and so here, we show anonymised examples of those data presentations. We propose that these methods can greatly aid reservoir management teams in their approach to T&O monitoring and can be used to implore more sustainable management pipelines, safeguarding future water sources
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