Tracing the Attention of Moving Citizens

With the widespread use of mobile computing devices in contemporary society, our trajectories in the physical space and virtual world are increasingly closely connected. Using the anonymous smartphone data of $1 \times 10^5$ users in 30 days, we constructed the mobility network and the attention network to study the correlations between online and offline human behaviours. In the mobility network, nodes are physical locations and edges represent the movements between locations, and in the attention network, nodes are websites and edges represent the switch of users between websites. We apply the box-covering method to renormalise the networks. The investigated network properties include the size of box $l_B$ and the number of boxes $N(l_B)$. We find two universal classes of behaviours: the mobility network is featured by a small-world property, $N(l_B) \simeq e^{-l_B}$, whereas the attention network is characterised by a self-similar property $N(l_B) \simeq l_B^{-\gamma}$. In particular, with the increasing of the length of box $l_B$, the degree correlation of the network changes from positive to negative which indicates that there are two layers of structure in the mobility network. We use the results of network renormalisation to detect the community and map the structure of the mobility network. Further, we located the most relevant websites visited in these communities, and identified three typical location-based behaviours, including the shopping, dating, and taxi-calling. Finally, we offered a revised geometric network model to explain our findings in the perspective of spatial-constrained attachment.Comment: 15 pages, 8 figure

Systemic similarity analysis of compatibility drug-induced multiple pathway patterns _in vivo_

A major challenge in post-genomic research is to understand how physiological and pathological phenotypes arise from the networks of expressed genes and to develop powerful tools for translating the information exchanged between gene and the organ system networks. Although different expression modules may contribute independently to different phenotypes, it is difficult to interpret microarray experimental results at the level of single gene associations. The global effects and response pathways of small molecules in cells have been investigated, but the quantitative details of the activation mechanisms of multiple pathways _in vivo_ are not well understood. Similar response networks indicate similar modes of action, and gene networks may appear to be similar despite differences in the behaviour of individual gene groups. Here we establish the method for assessing global effect spectra of the complex signaling forms using Global Similarity Index (GSI) in cosines vector included angle. Our approach provides quantitative multidimensional measures of genes expression profile based on drug-dependent phenotypic alteration _in vivo_. These results make a starting point for identifying relationships between GSI at the molecular level and a step toward phenotypic outcomes at a system level to predict action of unknown compounds and any combination therapy