901 research outputs found

    The Weight Distributions of Cyclic Codes and Elliptic Curves

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    Cyclic codes with two zeros and their dual codes as a practically and theoretically interesting class of linear codes, have been studied for many years. However, the weight distributions of cyclic codes are difficult to determine. From elliptic curves, this paper determines the weight distributions of dual codes of cyclic codes with two zeros for a few more cases

    The effect of Hus1 on ionizing radiation sensitivity is associated with homologous recombination repair but is independent of non-homologous end-joining

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    Mammalian Hus1 plays an important role in maintaining genomic integrity. Cells lacking mouse Hus1 are hypersensitive to DNA damage inducers including UV and camptothecin (CPT). By using clonogenic assay, we show here that Hus1 deficient mouse cells are hypersensitive to ionizing radiation (IR) compared with their Hus1-positive counterparts. However, these cells show similar induction levels and similar rejoining rates of DNA double strand breaks (DSBs) following IR, indicating that the effect of Hus1 on cell radiosensitivity is independent of non-homologous end-joining (NHEJ). By combining an I-SceI-induced-DNA DSBs system and a siRNA approach, we also show that knocking down Hus1 decreases the efficiency of homologous recombination repair (HRR), which is associated with the cellular sensitivity to IR-induced killing. Together, these results indicate that the role of Hus1 affecting the sensitivity of cells to IR-induced killing is independent of NHEJ but might be linked to HRR
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