1 research outputs found
Ruthenium-Catalyzed Straightforward Synthesis of 1,2,3,4-Tetrahydronaphthyridines via Selective Transfer Hydrogenation of Pyridyl Ring with Alcohols
Through
a ruthenium-catalyzed selective hydrogen transfer coupling
reaction, a novel straightforward synthesis of 1,2,3,4-tetrahydronaphthyridines
from <i>o</i>-aminopyridyl methanols and alcohols has been
developed. The synthetic protocol proceeds in an atom- and step-economic
fashion together with the advantages of operational simplicity, broad
substrate scope, production of water as the only byproduct, and no
need for external reducing reagents such as high pressure H<sub>2</sub> gas, offering a highly practical approach for accessing this type
of structurally unique products