38,540 research outputs found
Current Dissipation in Thin Superconducting Wires: Accurate Numerical Evaluation Using the String Method
Current dissipation in thin superconducting wires is numerically evaluated by
using the string method, within the framework of time-dependent Ginzburg-Landau
equation with a Langevin noise term. The most probable transition pathway
between two neighboring current-carrying metastable states, continuously
linking the Langer-Ambegaokar saddle-point state to a state in which the order
parameter vanishes somewhere, is found numerically. We also give a numerically
accurate algorithm to evaluate the prefactors for the rate of current-reducing
transitions.Comment: 25 pages, 5 figure
A Novel Alcohol-Sensitive Site in the M3 Domain of the NMDA Receptor GluN2A Subunit
Accumulating studies have demonstrated that the N-methyl-D-aspartate receptor is one of the most important targets of ethanol in the central nervous system. Previous studies from this laboratory have found that one position in the third (F637) and two positions in the fourth (M823 and A825) membrane-associated (M) domains of the N-methyl-D-aspartate receptor GluN2A subunit modulate alcohol action and ion channel gating. Using site-directed mutagenesis and whole-cell patch-clamp recording, we have found an additional position in M3 of the GluN2A subunit, F636, which significantly influences ethanol sensitivity and functionally interacts with F637. Tryptophan substitution at F636 significantly decreased the ethanol IC50, decreased both peak and steady-state glutamate EC50, and altered agonist deactivation and apparent desensitization. There was a significant correlation between steadystate: peak current ratio, a measure of desensitization, and ethanol IC50 values for a series of mutants at this site, raising the possibility that changes in ethanol sensitivity may be secondary to changes in desensitization. Mutant cycle analysis revealed a significant interaction between F636 and F637 in regulating ethanol sensitivity. Our results suggest that F636 in the M3 domain of the GluN2A subunit not only influences channel gating and agonist potency, but also plays an important role in mediating the action of ethanol. These studies were supported by grants R01 AA015203-01A1 and AA015203-06A1 from the NIAAA to R.W.P
Qualitative picture of a new mechanism for high-Tc superconductors
Xu et al. observed enhanced Nernst effect and Iguchi et al. observed patched
diamagnetism, both well above in underdoped high- superconductors
(HTSCs). A new mechanism is proposed here, which seems to naturally explain, at
least qualitatively, these observations, as well as the d-wave nature and
continuity of pseudogap and pairing gap, the tunneling conductance above ,
as well as , , , etc. This mechanism combines
features of dynamic charged stripes, preformed pairs, and spin-bags: At
appropriete doping levels, the doped holes (and perhaps also electrons) will
promote the formation of anti-phase islands in short-range anti-ferromagnetic
order. On the boundary of each such island reside two doped carriers; the
unscreened Coulomb repulsion between them stabilizes its size.
Superconductivity results when such ``pre-formed pairs'' Bose-condense.Comment: 8 pages, 4 figures, New3SC-4 Conference Proceedings, to be published
in ijmp
Gender Differentials in the Payoff to Schooling in China
This paper examines the gender differential in the payoff to schooling in China. The analyses are conducted separately for rural and urban areas, and are based on a framework provided by the over education/required education/under education literature, and the decomposition developed by Chiswick and Miller (2008). It shows that the payoff to correctly matched education in rural China is much higher for females than for males. Associated with this, the wage penalty where workers are under qualified in their occupation is greater for females than for males. Both of these factors are shown to be linked to the higher payoff to schooling for females than for males. Over educated females, however, are advantaged compared with their male counterparts, though this has little effect on the differential in the payoff to schooling between males and females in rural China. These findings are interpreted using the explanations offered for the gender differential in the payoff to schooling in the growing literature on earnings determination in China. The payoffs to actual years of schooling for males and females in urban China are remarkably similar in this study.schooling, earnings, rates of return, China
Zero-bias Anomaly of Quantum Point Contacts in the Low-Conductance Limit
Most quantum point contacts (QPCs) fabricated in high-mobility 2D electron
gases show a zero-bias conductance peak near pinchoff, but the origin of this
peak remains a mystery. Previous experiments have primarily focused on the
zero-bias peak at moderate conductance, in the range (1-2)e^2/h. Here,
measurements are presented of zero-bias peaks that persist down to
10^{-4}e^2/h. Magnetic field and temperature dependencies of the zero-bias peak
in the low-conductance limit are qualitatively different from the analogous
phenomenology at higher conductance, with implications for existing theoretical
models of transport in low-density QPCs
Large enhancement of the effective second-order nonlinearity in graphene metasurfaces
Using a powerful homogenization technique, one- and two-dimensional graphene
metasurfaces are homogenized both at the fundamental frequency (FF) and second
harmonic (SH). In both cases, there is excellent agreement between the
predictions of the homogenization method and those based on rigorous numerical
solutions of Maxwell equations. The homogenization technique is then employed
to demonstrate that, owing to a double-resonant plasmon excitation mechanism
that leads to strong, simultaneous field enhancement at the FF and SH, the
effective second-order susceptibility of graphene metasurfaces can be enhanced
by more than three orders of magnitude as compared to the intrinsic
second-order susceptibility of a graphene sheet placed on the same substrate.
In addition, we explore the implications of our results on the development of
new active nanodevices that incorporate nanopatterned graphene structures.Comment: 11 pages, 12 figure
Magnetic Excitations in the High Tc Iron Pnictides
We calculate the expected finite frequency neutron scattering intensity based
on the two-sublattice collinear antiferromagnet found by recent neutron
scattering experiments as well as by theoretical analysis on the iron
oxypnictide LaOFeAs. We consider two types of superexchange couplings between
Fe atoms: nearest-neighbor coupling J1 and next-nearest-neighbor coupling J2.
We show how to distinguish experimentally between ferromagnetic and
antiferromagnetic J1. Whereas magnetic excitations in the cuprates display a
so-called resonance peak at (pi,pi) (corresponding to a saddlepoint in the
magnetic spectrum) which is at a wavevector that is at least close to nesting
Fermi-surface-like structures, no such corresponding excitations exist in the
iron pnictides. Rather, we find saddlepoints near (pi,pi/2) and (0,pi/2)(and
symmetry related points). Unlike in the cuprates, none of these vectors are
close to nesting the Fermi surfaces.Comment: 4 pages, 5 figure
A Site of Alcohol Action at the NMDA Receptor M3-M4 Domain Interface
The N-methyl-D-aspartate (NMDA) glutamate receptor is a major target of ethanol in the brain. Previous studies have identified positions in the third and fourth membrane-associated (M) domains of the NMDA receptor GluN1 and GluN2A subunits that influence alcohol sensitivity. The structural model of the NMDA receptor, predicted from the structure of the related GluA2 subunit, indicates a close apposition of the alcohol-sensitive positions in M3 and M4 between the two subunit types. We investigated possible interactions between the M3 and M4 domain positions of the two subunit types affecting the ethanol sensitivity of the receptor by using dual substitution mutants. In an initial screen of single-substitution mutants, we found that a position in both subunits adjacent to one previously identified, GluN1(G638) and GluN2A(F636), can strongly regulate ethanol sensitivity. Significant interactions affecting ethanol inhibition were observed at four pairs of positions in GluN1/GluN2A: G638/M823, F639/L824, M818/F636, and L819/F637. Two of these interactions involve a position in M4 of both subunits, GluN1(M818) and GluN2A(L824), that does not by itself alter ethanol sensitivity, and one of the previously identified positions affecting ethanol sensitivity, GluN2A(A825), did not appear to interact with any other position tested. These results also indicate a shift by one position of the predicted alignment of the GluN1 M4 domain. These findings have allowed for the refinement of the NMDA receptor M domain structure, and support the existence of four sites of alcohol action on the NMDA receptor at the M3-M4 domain intersubunit interfaces. These studies were supported by grants R01 AA015203-01A1 and AA015203-06A1 from the NIAAA to R.W.P
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