Polymer Translocation througha Pore in a Membrane

We construct a new statistical physical model of polymer translocation through a pore in a membrane treated as the diffusion process across a free energy barrier. We determine the translocation time in terms of chain flexibility yielding an entropic barrier, as well as in terms of the driving mechanisms such as transmembrane chemical potential difference and Brownian ratchets. It turns out that, while the chemical potential differences induce pronounced effects on translocation due to the long-chain nature of the polymer, the ratchets suppress this effect and chain flexibility.Comment: 4 pages, 5 figures, published in Phys. Rev. Lett. 77, 783(1996

Multi-frequency imaging of perfectly conducting cracks via boundary measurements

Imaging of perfectly conducting crack(s) in a 2-D homogeneous medium using boundary data is studied. Based on the singular structure of the Multi-Static Response (MSR) matrix whose elements are normalized by an adequate test function at several frequencies, an imaging functional is introduced and analyzed. A non-iterative imaging procedure is proposed. Numerical experiments from noisy synthetic data show that acceptable images of single and multiple cracks are obtained.Comment: 4 pages, 3 figure

Separation of gas mixtures by centrifugation

Magnetohydrodynamic (MHD) centrifuge utilizing electric currents and magnetic fields produces a magnetic force which develops supersonic rotational velocities in gas mixtures. Device is superior to ordinary centrifuges because rotation of gas mixture is produced by MHD force rather than mechanical means

Soluble Epoxide Hydrolase Inhibition for Ocular Diseases: Vision for the Future

Ocular diseases cause visual impairment and blindness, imposing a devastating impact on quality of life and a substantial societal economic burden. Many such diseases lack universally effective pharmacotherapies. Therefore, understanding the mediators involved in their pathophysiology is necessary for the development of therapeutic strategies. To this end, the hydrolase activity of soluble epoxide hydrolase (sEH) has been explored in the context of several eye diseases, due to its implications in vascular diseases through metabolism of bioactive epoxygenated fatty acids. In this mini-review, we discuss the mounting evidence associating sEH with ocular diseases and its therapeutic value as a target. Substantial data link sEH with the retinal and choroidal neovascularization underlying diseases such as wet age-related macular degeneration, retinopathy of prematurity, and proliferative diabetic retinopathy, although some conflicting results pose challenges for the synthesis of a common mechanism. sEH also shows therapeutic relevance in non-proliferative diabetic retinopathy and diabetic keratopathy, and sEH inhibition has been tested in a uveitis model. Various approaches have been implemented to assess sEH function in the eye, including expression analyses, genetic manipulation, pharmacological targeting of sEH, and modulation of certain lipid metabolites that are upstream and downstream of sEH. On balance, sEH inhibition shows considerable promise for treating multiple eye diseases. The possibility of local delivery of inhibitors makes the eye an appealing target for future sEH drug development initiatives

Field Theoretic Approach to Long Range Reactions

We analyze bimolecular reactions that proceed by a long-ranged reactive interaction, using a field theoretic approach that takes into account fluctuations. We consider both the one-species, $A+A \to \emptyset$ reaction and the two-species, $A+B \to \emptyset$ reaction. We consider both mobile and immobile reactants, both in the presence and in the absence of adsorption.Comment: 9 pages. 4 figures. Uses svjour macros. To appear in Europ. Phys. J.

Are Broker Quotes Too Optimistic? Korean Evidence

We examine the behavior of broker quotes in Korean housing markets by comparing the Kookmin Bank apartment (a condominium in a high- rise residential building) price index, a broker quote based apartment price index, and a repeat sales apartment price index that we built using transaction prices, which have become available since January 2006. Broker quotes may differ from actual prices depending on the housing market conditions. Specifically, we test the hypotheses: (1) price increases shown by the broker quote based apartment price index are greater than those shown by the repeat sales apartment price index in an up market; and (2) the broker quote based price index shows a far less price reduction than the repeat sales price index in a down market. We find that indeed in a down market, the broker quote based price index shows far less price reduction than the repeat sales price index (5.75%-8.07%). However, the broker quote based price index does not distort the prices in an up market, where trading volumes are high. It appears that the price inflation in the broker quotes rises as the transaction volume drops. While broker quotes are substantially higher than transaction prices in a down market, the broker sentiment, which is a qualitative assessment of market conditions, appears to be more in line with transaction prices. We have also documented that the broker quote based index reaches its peak about two months after the peak of the repeat sales based index. Finally, broker quotes are smooth in comparison to transaction prices and they are smoothed more in a down market than an up market. Our results suggest that an optimistic view of broker quotes is problematic only in down markets where trading volumes are limited. The price inflation in broker quotes is a risk to the financial system in a market with only a broker quote based index in that it overstates the collateral values underlying mortgage loans in a down market.Broker quotes; Broker quote based apartment price index; Repeat sales apartment price index; House price cycle; Broker sentiment; Korean housing markets

Mean Field Theoretical Structure of He and Be Isotopes

The structures of He and Be even-even isotopes are investigated using an axially symmetric Hartree-Fock approach with a Skyrme-IIIls mean field potential. In these simple HF calculations, He and Be isotopes appear to be prolate in their ground states and Be isotopes have oblate shape isomeric states. It is also shown that there exists a level crossing when the nuclear shape changes from the prolate state to the oblate state. The single neutron levels of Be isotopes exhibit a neutron magic number 6 instead of 8 and show that the level inversion between 1/2- and 1/2+ levels occurs only for a largely deformed isotope. Protons are bound stronger in the isotope with more neutrons while neutron levels are somewhat insensitive to the number of neutrons and thus the nuclear size and also the neutron skin become larger as the neutron number increases. In these simple calculations with Skyrme-IIIls interaction no system with a clear indication of neutron halo was found among He and Be isotopes. Instead of it we have found 8He+2n, 2n+8He+2n, and 16Be+2n like chain structures with clusters of two correlated neutrons. It is also shown that 8He and 14Be in their ground states are below the neutron drip line in which all nucleons are bound with negative energy and that 16Be in its ground state is beyond the neutron drip line with two neutrons in positive energy levels.Comment: CM energy correction, 1 figure and more discussions adde