Random forest classification.

<p>Random forest classification presenting the prioritized list of 30 metabolites. Metabolites with X- prefix are unknown and need to be identified. Y-axis is the prioritized list in which we as move downward, there is decrease in the accuracy (X-axis) of classification of the two samples.</p

Principal component analysis (PCA).

<p>PCA plot showing separation of the sun-exposed and sun-protected skin samples. 1- unexposed inner arm. 2- exposed outer arm.</p

Summary of the Biochemical Pathways and Compounds altered in sun-exposed sites.

<p>Increased: The metabolites were up-regulated in biopsies from sun-exposed skin.</p><p>Decreased: The metabolites were down-regulated in biopsies from sun-exposed skin.</p

Adenine metabolism.

<p>This schematic presents the steps in the adenosine and guanosine pathway leading to production of uric acid. ATP – Adenosine triphosphate, GMP – guanosine monophosphate, IMP – inosine monophosphate. Red arrows – higher accumulation, green arrow – low accumulation.</p

Distribution of the metabolomics data with colors depicting the levels of metabolites.

<p>Distribution of the metabolomics data with colors depicting the levels of metabolites.</p

Methionine-Glutathione metabolism.

<p>This figures details the levels of various metabolites that were detected in the pathaway. Red arrow indicates higher levels, green arrow indicates lower levels and black arrow indicates no change in the levels of the metabolite.</p

The classification accuracy.

<p>The table represents the classification accuracy with perfect classification in Sun-exposed and very high accuracy in Sun-protected skin samples using the prioritized list of 30 metabolites through Random Forest Classification.</p

Nicotine metabolism pathway.

<p>This schematic presents the de novo and salvage pathways through which the NAD can be generated. Red arrow indicates higher accumulation and black arrow indicates no change.</p

Distribution of fraction of Dissimilar function (Ordinate: fraction) versus sequence identity (X-axis in bins of 10%)

<p><b>Copyright information:</b></p><p>Taken from "Quantitative sequence-function relationships in proteins based on gene ontology"</p><p>http://www.biomedcentral.com/1471-2105/8/294</p><p>BMC Bioinformatics 2007;8():294-294.</p><p>Published online 8 Aug 2007</p><p>PMCID:PMC1976327.</p><p></p> The top of each box is the upper 75percentile, the bottom is the lower 25percentile. The median of each box is also shown but is superimposed on the 25percentile. The circles are single extreme cases. The line joins the mean fraction of Dissimilar function at each level of sequence identity. The mean is well above the median due to the extreme skewness of the distribution towards mostly similar function

Distribution of functional distances (Y-axis in fraction) in bins of 20% sequence identity (X-axis)

<p><b>Copyright information:</b></p><p>Taken from "Quantitative sequence-function relationships in proteins based on gene ontology"</p><p>http://www.biomedcentral.com/1471-2105/8/294</p><p>BMC Bioinformatics 2007;8():294-294.</p><p>Published online 8 Aug 2007</p><p>PMCID:PMC1976327.</p><p></p> The graphs present the distribution of all functions (Similar + Dissimilar)