2,007 research outputs found
I media interculturali in Italia
I contenuti di questo articolo rientrano nel settore della Sociologia dei Processi Culturali e Comunicativi. In pratica, si divulgano i risultati di una ricerca inerente una fenomenologia relativamente nuova per il nostro Paese: i media interculturali
La Scuola Rossello nel quartiere Flaminio
Il saggio è frutto di una breve ricerca svolta per l'Istituto Rossello di Roma in occasione del centenario della struttura. Attraverso il recupero di documenti originali dell'Archivio e l'uso di fonti bibliografiche appropriate, si è indagata la storia e la funzione sociale della Scuola nel contesto del quartiere Flaminio
Measurement of y_CP with D^0 mesons from semileptonic B-meson decays at LHCb
This thesis reports a measurement of the charm-mixing observable yCP using D^0->K^+K^−, D^0->pi^+pi^−, and D^0->K^−pi^+ decays, where the D^0 meson originates from semileptonic B-meson decays. The analysis is performed on the full Run 2 dataset collected by LHCb with pp collisions at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 5.57 fb^−1 . The dataset is divided into 18 exclusive D^0 decay-time bins, in which an invariant mass fit is performed to extract the signal yield for each decay channel. The ratios of KK/Kpi and pipi/Kpi yields in each bin, corrected for the efficiency as function of the decay-time estimated from a Monte Carlo sample, are then fitted to extract the difference between the decay widths of KK (pipi) and Kpi channels, ∆Γ^{KK} (∆Γ^{pipi}). Finally, y_CP is computed as ∆Γt(D^0), where t(D^0) is the precisely known D^0 lifetime. The values obtained from the two decay channels with preliminary systematic uncertainties are y_CP^{KK} = (75.98 ± 0.07 (stat) ± 0.06 (syst))%, y_CP^{pipi} = (76.29 ± 0.14 (stat) ± 0.05 (syst))%, which are consistent with each other (the central values are blind), and when combined yield a result of y_CP = (76.08 ± 0.06 (stat) ± 0.04 (syst))%. The analysis aims at updating the previous LHCb measurement with a larger data sample size, and is expected to improve the precision by a factor two with respect to the current world average y_CP = (0.715 ± 0.111)%
Translocation of NS3 from Hepatitis C Virus on RNA: Insights from Atomistic Molecular Simulations
Helicases are motor proteins that unwind double stranded nucleic acids and
are important parts of the genetic apparatus. A notable member of this family
of enzymes is the nun-structural protein NS3 from Hepatitis C Virus. NS3
helicase unwinds nucleic acids by translocating along a single strand. Single
molecule experiments and X-ray crystallography suggest that NS3 follows an
inchworm-like motion during the translocation mechanism, consuming one ATP
molecule per cycle. In spite of the available experimental data, the mechanistic
and chemical details of the translocation process are still unclear.
The aim of this study is to model at atomistic detail the NS3h-RNA complex
at the different stages of the translocation. For this purpose, atomistic molecular
dynamics simulations were performed in explicit solvent in the presence and
in the absence of ATP and ADP. Simulations were initialized based on existing
crystallographic structures. All the stages of translocation were considered, and
their relative stabilities were analyzed by computing electrostatic interactions,
relative enthalpies, and hydrogen-bond patterns. Additionally, well-tempered
metadynamics and Hamiltonian replica exchange simulations were performed
to characterize the free-energy landscape associated to translocation and to
describe the conformational transitions
Fossil lizards and worm lizards (Reptilia, Squamata) from the Neogene and Quaternary of Europe: an overview
Lizards were and still are an important component of the European herpetofauna. The modern European lizard fauna started to set up in the Miocene and a rich fossil record is known from Neogene and Quaternary sites. At least 12 lizard and worm lizard families are represented in the European fossil record of the last 23 Ma. The record comprises more than 3000 occurrences from more than 800 localities, mainly of Miocene and Pleistocene age. By the beginning of the Neogene, a marked faunistic change is detectable compared to the lizard fossil record of Palaeogene Europe. This change is reflected by other squamates as well and might be related to an environmental deterioration occurring roughly at the Oligocene/Miocene boundary. Nevertheless, the diversity was still rather high in the Neogene and started to decrease with the onset of the Quaternary glacial cycles. This led to the current impoverished lizard fauna, with the southward range shrinking of the most thermophilic taxa (e.g., agamids, amphisbaenians) and the local disappearance of other groups (e.g., varanids). Our overview of the known fossil record of European Neogene and Quaternary lizards and worm lizards highlighted a substantial number of either unpublished or poorly known occurrences often referred to wastebasket taxa. A proper study of these and other remains, as well as a better sampling of poorly explored time ranges (e.g., Pliocene, Holocene), is needed and would be of utmost importance to better understand the evolutionary history of these reptiles in Europe
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