IGR J17488-2338: a newly discovered giant radio galaxy

We present the discovery of a large scale radio structure associated with IGR J17488--2338, a source recently discovered by \emph{INTEGRAL} and optically identified as a broad line AGN at redshift 0.24. At low frequencies, the source properties are those of an intermediate-power FR II radio galaxy with a linear size of 1.4\,Mpc. This new active galaxy is therefore a member of a class of objects called Giant Radio Galaxies (GRGs), a rare type of radio galaxies with physical sizes larger than 0.7\,Mpc; they represent the largest and most energetic single entities in the Universe and are useful laboratories for many astrophysical studies. Their large scale structures could be due either to special external conditions or to uncommon internal properties of the source central engine The AGN at the centre of IGR J17488--2338 has a black hole of 1.3$\times$10$^9$ solar masses, a bolometric luminosity of 7$\times$10$^{46}$erg\,s$^{-1}$ and an Eddington ratio of 0.3, suggesting that it is powerful enough to produce the large structure observed in radio. The source is remarkable also for other properties, among which its X-ray absorption, at odds with its type 1 classification, and the presence of a strong iron line which is a feature not often observed in radio galaxies.Comment: 4 pages, 3 figures, accepted for publication on Astronomy and Astrophysic

IGR J14488-4008: an X-ray peculiar giant radio galaxy discovered by INTEGRAL

In this paper we report the discovery and detailed radio/X-ray analysis of a peculiar giant radio galaxy (GRG) detected by INTEGRAL, IGR J14488-4008. The source has been recently classified as a Seyfert 1.2 galaxy at redshift 0.123; the radio data denote the source to be a type II Fanaroff-Riley radio galaxy, with a linear projected size exceeding 1.5 Mpc, clearly assigning IGR J14488-4008 to the class of GRG. In the X-rays, the source shows a remarkable spectrum, characterised by absorption by ionised elements, a characteristic so far found in only other four broad line radio galaxies.Comment: 7 pages, 3 tables, 5 figures. Accepted for publication on MNRA

Il momento ricreativo-motorio nella Scuola dell’Infanzia

Motor activity linked to recreational time in Kindergarten was the key theme of this systematic review which aimed to point out the positive relationship established between these three components.This is a topic that requires further updates over the years, as the school landscape is constantly changing its appearance and evolving in its structure and in the ideals behind it, expanding informations and actions. Newest researches highlights the growing childhood obesity already in preschool children, drawing attention to the importance of doing physical activity at this young age. This revision therefore aim to determine the possible advantage for children by implementing a motor recreation in Kindergarten; how much recreation could be of support in order to increase the time spent in motor actions. This study analyzed the concepts of recreation with all the declinations of the case, focusing on space, time and activities. Emphasis was also given to the whole motor part that concerns development of the child in the range from two to five years, presenting all the various components and the relationship between physical, cognitive, emotional and social development, analyzingat last a motor program that could be a solution to the encountered problems. Twenty-two articles and protocols were selected, placed in the years between 2000 and 2020. The results were analyzed and compared to identify similarities and differences useful for further and future experiments.L’attività motoria legata al tempo ricreativo nella Scuola dell’Infanzia è stato il tema chiave di questa revisione sistematica che si è posta l’obiettivo di sottolineare la relazione positiva che si instaura tra queste tre componenti. Questo è un argomento che richiede sempre ulteriori aggiornamenti, in quanto il panorama scolastico cambia continuamente aspetto ed evolve nella struttura e negli ideali alla base, ampliando informazioni e azioni. Le nuove ricerche sottolineano la crescente obesità infantile già nei bambini in età prescolare, richiamando nuovamente l’attenzione sull’importanza di fare attività fisica già da questa età. Questa revisione vuole quindi determinare se e quale vantaggio esiste nell’attuare una ricreazione motoria nella Scuola dell’Infanzia. Quanto la ricreazione possa essere da supporto al fine di aumentare il tempo speso in azioni motorie. Si analizzano i concetti di ricreazione con tutte le declinazioni, focalizzandosi su spazi, tempi, attività. Inoltre, in merito alla parte motoria che riguarda lo sviluppo nella fascia dai due ai cinque anni, la relazione tra sviluppo fisico, cognitivo, emotivo e sociale. Sono stati selezionati ventidue tra articoli e protocolli, collocati negli anni tra il 2000 e il 2020. I risultati sono stati analizzati e confrontati per identificare somiglianze e differenze utili per ulteriori e future sperimentazioni

Il momento ricreativo-motorio nella Scuola dell’Infanzia

none2noL’attività motoria legata al tempo ricreativo nella Scuola dell’Infanzia è stato il tema chiave di questa revisione sistematica che si è posta l’obiettivo di sottolineare la relazione positiva che si instaura tra queste tre componenti. Questo è un argomento che richiede sempre ulteriori aggiornamenti, in quanto il panorama scolastico cambia continuamente aspetto ed evolve nella struttura e negli ideali alla base, ampliando informazioni e azioni. Le nuove ricerche sottolineano la crescente obesità infantile già nei bambini in età prescolare, richiamando nuovamente l’attenzione sull’importanza di fare attività fisica già da questa età. Questa revisione vuole quindi determinare se e quale vantaggio esiste nell’attuare una ricreazione motoria nella Scuola dell’Infanzia. Quanto la ricreazione possa essere da supporto al fine di aumentare il tempo speso in azioni motorie. Si analizzano i concetti di ricreazione con tutte le declinazioni, focalizzandosi su spazi, tempi, attività. Inoltre, in merito alla parte motoria che riguarda lo sviluppo nella fascia dai due ai cinque anni, la relazione tra sviluppo fisico, cognitivo, emotivo e sociale. Sono stati selezionati ventidue tra articoli e protocolli, collocati negli anni tra il 2000 e il 2020. I risultati sono stati analizzati e confrontati per identificare somiglianze e differenze utili per ulteriori e future sperimentazioni.openValentini, Manuela; Venturi, LetiziaValentini, Manuela; Venturi, Letizi

A wireless crackmeters network for the analysis of rock falls at the Pietra di Bismantova natural heritage site (Northern Apennines, Italy)

The Pietra di Bismantova (Northern Apennines, Italy) is a large calcareous sandstone rock slab which is distinctively bordered by sub-vertical cliffs that are affected by rock falls, a risk for people visiting the area and for key assets located at the foot of this natural heritage site. A wireless sensor network based on wireless nodes, crack meters and thermometers has been made operative in January 2015 in order to study the response of fractures to changing environmental conditions and support the spatial and temporal zonation of rock fall hazard in this natural heritage site. Results from the first eight months of monitoring show that intense snowfall and low temperatures can determine short-term pulses of fracture opening while the increase of temperature throughout summer determines long-term fracture closing trends. Moreover, as soon as February 2015 one of the crack meters monitored the rapid trend of crack opening that occurred prior to the failure of a large rock slab of about 200 cubic meters

Association of miR-146a-5p and miR-21-5p with Prognostic Features in Melanomas

Simple Summary Cutaneous melanoma is one of the most lethal tumors among skin cancers and its incidence is rising worldwide. Recent data support the role of microRNAs (miRNAs) in melanoma carcinogenesis and their potential use as disease biomarkers. The aim of this study was to evaluate if miR-21-5p and miR-146a-5p expression is associated with melanoma histopathologic features including Breslow thickness, histological subtype, ulceration and regression status, and mitotic index. Our results showed that the combination of miRNAs and prognostic features can better differentiate cutaneous melanoma prognostic groups, considering overall survival and time-to-relapse. Our findings support the advantage of using molecular and diagnostic features in melanoma prognostication.Abstract Background: Cutaneous melanoma (CM) is one of the most lethal tumors among skin cancers and its incidence is rising worldwide. Recent data support the role of microRNAs (miRNAs) in melanoma carcinogenesis and their potential use as disease biomarkers. Methods: We quantified the expression of miR-146a-5p and miR-21-5p in 170 formalin-fixed paraffin embedded (FFPE) samples of CM, namely 116 superficial spreading melanoma (SSM), 26 nodular melanoma (NM), and 28 lentigo maligna melanoma (LMM). We correlated miRNA expression with specific histopathologic features including Breslow thickness (BT), histological subtype, ulceration and regression status, and mitotic index. Results: miR-146a-5p and miR-21-5p were significantly higher in NM compared to SSM and LMM. The positive correlation between miR-146a-5p and miR-21-5p expression and BT was confirmed for both miRNAs in SSM. Considering the ulceration status, we assessed that individual miR-21-5p expression was significantly higher in ulcerated CMs. The increased combined expression of the two miRNAs was strongly associated with ulceration (p = 0.0093) and higher mitotic rate (>= 1/mm2) (p = 0.0005). We demonstrated that the combination of two-miRNA expression and prognostic features (BT and ulceration) can better differentiate cutaneous melanoma prognostic groups, considering overall survival and time-to-relapse clinical outcomes. Specifically, miRNA expression can further stratify prognostic groups among patients with BT >= 0.8 mm but without ulceration. Our findings provide further insights into the characterization of CM with specific prognostic features. The graphical abstract was created with BioRender.com

Reingeniería de los procesos y optimización integral del servicio de Odontología

El proyecto se basa en el estudio del área de odontología del Hospital Dr. Ricardo Gutiérrez de la ciudad de La Plata (Buenos Aires) Con el objetivo de encontrar falencias en la gestión, dados los recursos y la capacidad disponible, nos apoyaremos en el Software de Decisión, Strat Pro, para lograr una mejora y optimización integral del servicio. En nuestras primeras visitas al hospital, hemos observado poco espacio físico con el que cuentan, asi como también limitado tiempo de prestación del servicio debido a la falta de instrumentos para la atención. La prestación cuenta con 14 personas, entre odontólogos, residentes y administrativos que atienden a personas sumamente carenciadas y aun así, la demanda del hospital es excesiva para la capacidad productiva del mismo. Se pretende, en conclusión, lograr una reingeniería del proceso de trabajo de manera tal que sea posible atender a una mayor cantidad de pacientes con una mayor calidad del servicio e intentar evitar las molestias que surgen como consecuencia de las colas de espera. Buscamos entonces, obtener una mayor eficiencia, para contribuir a aumentar el bienestar social en un área tan esencial como la salud pública.

Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector

A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb−1 of proton–proton collision data recorded by the ATLAS experiment at √s = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements