254 research outputs found

    Eficiência de uso da radiação fotossinteticamente ativa de três forrageiras nativas dos campos sulinos sob dois níveis de sombra e a pleno sol.

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    Este trabalho teve como objetivo determinar a eficiência de uso da radiação fotossinteticamente ativa (EUR) de Paspalum notatum, Paspalum regnellii e Paspalum dilatatum sob 50% e 80% de sombra artificial e a pleno sol, buscando avaliar o potencial de uso destas espécies em sistemas silvipastoris na região sul do país e a utilização de forrageiras nativas nestes sistemas integrados

    Bacterial isolation in samples of goat milk.

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    The aim of this study was to monitor the presence of pathogens causing caprine mastitis during three months in a properties situated in the region of the Zona da Mata of Minas Gerais. The presence of isolated microorganisms of goat milk stresses the importance of prophylaxis measures and control of subclinical mastitis in the flock. That?s because the isolated microorganisms exhibit great importance for public health, as they are possible producers of staphylococcal toxin, and therefore, possible causes of food poisoning

    Insulin-like growth factor receptor 1 (IGF1R) expression and survival in surgically resected non-small-cell lung cancer (NSCLC) patients

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    Background: The purpose of this study is to investigate the prognostic role of insulin-like growth factor receptor 1 (IGF1R) expression in surgically resected non-small-cell lung cancer (NSCLC). Patient characteristics and methods: This retrospective study was conducted in 369 stage I-II-IIIA, surgically resected, NSCLC patients. Patients exposed to anti-epidermal growth factor receptor (EGFR) agents were excluded. IGF1R expression was evaluated by immunohistochemistry in tissue microarray sections. Results: A positive IGF1R expression (score‚ÄČ‚Č•‚ÄČ100) was observed in 282 cases (76.4%) and was significantly associated with squamous cell histology (P‚ÄČ=‚ÄČ0.04) and with grade III differentiation (P‚ÄČ=‚ÄČ0.02). No difference in survival was observed between the positive and negative group when score 100 was used as cut-off for discriminating a positive versus a negative IGF1R result (52 versus 48 months, P‚ÄČ=‚ÄČ0.99) or when median value of IGF1R expression was used (45 versus 55 months, P‚ÄČ=‚ÄČ0.36). No difference in survival was observed between IGF1R-positive and -negative patients in a subgroup of stage I-II adenocarcinoma (n‚ÄČ=‚ÄČ137) with known EGFR mutation and copy number status. Conclusions: IGF1R expression does not represent a prognostic factor in resected NSCLC patients. Patients with squamous cell carcinoma overexpress IGF1R more frequently than patients with nonsquamous histology, justifying the different sensitivity to anti-IGF1R agents observed in clinical trial

    Theoretical and experimental differential cross sections for electron impact excitation of the electronic bands of furfural

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    13 p√°gs.; 8 figs.; 6 tabs.We report results from a joint experimental and theoretical investigation into electron scattering from the important industrial species furfural (CHO). Specifically, differential cross sections (DCSs) have been measured and calculated for the electron-impact excitation of the electronic states of CHO. The measurements were carried out at energies in the range 20-40 eV, and for scattered-electron angles between 10¬įand 90¬į. The energy resolution of those experiments was typically ‚ąľ80 meV. Corresponding Schwinger multichannel method with pseudo-potential calculations, for energies between 6-50 eV and with and without Born-closure, were also performed for a sub-set of the excited electronic-states that were accessed in the measurements. Those calculations were undertaken at the static exchange plus polarisation-level using a minimum orbital basis for single configuration interaction (MOB-SCI) approach. Agreement between the measured and calculated DCSs was qualitatively quite good, although to obtain quantitative accord, the theory would need to incorporate even more channels into the MOB-SCI. The role of multichannel coupling on the computed electronic-state DCSs is also explored in some detail. ¬©2016 AIP Publishing LLCR.F.C.N. thanks CNPq (Brazil) and the Science Without Borders Programme for opportunities to study abroad. D.B.J. thanks the Australian Research Council (ARC) for financial support provided through a Discovery Early Career Research Award, while M.J.B. also thanks the ARC for their support. M.J.B. and M.C.A.L. acknowledge the Brazilian agencies CNPq and FAPEMIG. P.L.-V. acknowledges the Portuguese Foundation for Science and Technology (FCTMEC) through Grant Nos. PTDC/FIS-ATO/1832/2012 and UIO/FIS/00068/2013. G.G. acknowledges partial financial support from the Spanish Ministry MINECO (Project No. FIS2012-31230) and the European Union COST Action No. CM1301 (CELINA). Finally, R.F.d.C., M.T.d.N.V., M.H.F.B., and M.A.P.L. acknowledge support from the Brazilian agency CNPq and M.T.d.N.V. also thanks FAPESP.Peer Reviewe

    MYC and human telomerase gene (TERC) copy number gain in early-stage non-small cell lung cancer

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    Objectives: We investigated the frequency of MYC and TERC increased gene copy number (GCN) in early-stage non-small cell lung cancer (NSCLC) and evaluated the correlation of these genomic imbalances with clinicopathologic parameters and outcome. Materials and Methods: Tumor tissues were obtained from 113 resected NSCLCs. MYC and TERC GCNs were tested by fluorescence in situ hybridization (FISH) according to the University of Colorado Cancer Center (UCCC) criteria and based on the receiver operating characteristic (ROC) classification. Results: When UCCC criteria were applied, 41 (36%) cases for MYC and 41 (36%) cases for TERC were considered FISH-positive. MYC and TERC concurrent FISH-positive was observed in 12 cases (11%): 2 (17%) cases with gene amplification and 10 (83%) with high polysomy. By using the ROC analysis, high MYC (mean ‚Č•2.83 copies/cell) and TERC (mean ‚Č•2.65 copies/cell) GCNs were observed in 60 (53.1%) cases and 58 (51.3%) cases, respectively. High TERC GCN was associated with squamous cell carcinoma (SCC) histology (P=0.001). In univariate analysis, increased MYC GCN was associated with shorter overall survival (P=0.032 [UCCC criteria] or P=0.02 [ROC classification]), whereas high TERC GCN showed no association. In multivariate analysis including stage and age, high MYC GCN remained significantly associated with worse overall survival using both the UCCC criteria (P=0.02) and the ROC classification (P=0.008). Conclusions: Our results confirm MYC as frequently amplified in early-stage NSCLC and increased MYC GCN as a strong predictor of worse survival. Increased TERC GCN does not have prognostic impact but has strong association with squamous histology

    Differential cross sections for electron impact excitation of the electronic bands of phenol

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    We report results from a joint theoretical and experimental investigation into electron scattering from the important organic species phenol (C6H5OH). Specifically, differential cross sections (DCSs) have been measured and calculated for the electron-impact excitation of the electronic states of C6H5OH. The measurements were carried out at energies in the range 15‚Äď40 eV, and for scattered-electron angles between 10¬į and 90¬į. The energy resolution of those experiments was typically ‚ąľ80 meV. Corresponding Schwinger multichannel method with pseudo-potentials calculations, with and without Born-closure, were also performed for a sub-set of the excited electronic-states that were accessed in the measurements. Those calculations were conducted at the static exchange plus polarisation (SEP)-level using a minimum orbital basis for single configuration interaction (MOBSCI) approach. Agreement between the measured and calculated DCSs was typically fair, although to obtain quantitative accord, the theory would need to incorporate even more channels into the MOBSCI

    Low energy elastic and electronically inelastic electron scattering from biomolecules.

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    Reactions initiated by collisions with low-energy secondary electrons has been found to be the prominent\ud mechanism toward the radiation damage on living tissues through DNA strand breaks. Now it is widely accepted\ud that during the interaction with these secondary species the selective breaking of chemical bonds is triggered\ud by dissociative electron attachment (DEA), that is, the capture of the incident electron and the formation\ud of temporary negative ion states [1,2,3]. One of the approaches largely used toward a deeper understanding\ud of the radiation damage to DNA is through modeling of DEA with its basic constituents (nucleotide bases,\ud sugar and other subunits). We have tried to simplify this approach and attempt to make it comprehensible\ud at a more fundamental level by looking at even simple molecules. Studies involving organic systems such as\ud carboxylic acids, alcohols and simple ¬Įve-membered heterocyclic compounds are taken as starting points for\ud these understanding. In the present study we investigate the role played by elastic scattering and electronic\ud excitation of molecules on electron-driven chemical processes. Special attention is focused on the analysis of\ud the in¬įuence of polarization and multichannel coupling e¬ģects on the magnitude of elastic and electronically\ud inelastic cross-sections. Our aim is also to investigate the existence of resonances in the elastic and electronically\ud inelastic channels as well as to characterize them with respect to its type (shape, core-excited or Feshbach),\ud symmetry and position. The relevance of these issues is evaluated within the context of possible applications\ud for the modeling of discharge environments and implications in the understanding of mutagenic rupture of DNA\ud chains. The scattering calculations were carried out with the Schwinger multichannel method (SMC) [4] and\ud its implementation with pseudopotentials (SMCPP) [5] at di¬ģerent levels of approximation for impact energies\ud ranging from 0.5 eV to 30 eV.\ud References\ud [1] B. Boudai¬ģa, P. Cloutier, D. Hunting, M. A. Huels and L. Sanche, Science 287, 1658 (2000). [2] X. Pan, P.\ud Cloutier, D. Hunting and L. Sanche, Phys. Rev. Lett. 90, 208102 (2003). [3] F. Martin, P. D. Burrow, Z. Cai,\ud P. Cloutier, D. Hunting and L. Sanche, Phys. Rev. Lett. 93, 068101 (2004). [4] K. Takatsuka and V. McKoy,\ud Phys. Rev. A 24, 2437 (1981); ibid. Phys. Rev. A 30, 1734 (1984). [5] M. H. F. Bettega, L. G. Ferreira and\ud M. A. P. Lima, Phys. Rev. A 47, 1111 (1993)
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