16 research outputs found

    O uso sistêmico de antibióticos no tratamento da doença periodontal

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    TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.A boca humana, em condições fisiológias, contém um grande número de bacterias patológicas e não patológicas. Quando há um desequilíbrio entre a microbiota e as defesas do hospedeiro podem ocorrer diversas doenças, entre elas a doença periodontal; uma enfermidade extremamente comum na população mundial. Também conhecida como periodontite, ela representa um grupo de doenças inflamatórias de origem infecciosa e multifatorial que destrói os tecidos de suporte do dente. A prevenção e o tratamento dessa enfermidade são objetos de muitos estudos devido a sua extrema importância na Saúde Pública. Seu tratamento baseia-se em raspagem e alisamento radicular a campo aberto ou fechado associado à constante instrução de higiene oral e motivação do paciente. Esta é a terapia periodontal convencional, que na maioria dos casos possui êxito, entretanto nos casos em que a doença periodontal não regride, outras estratégias de tratamento são adotadas, entre elas o uso adjuvante de antibióticos. Este trabalho teve como objetivo revisar a literatura relacionada ao uso sistêmico de antibióticos no tratamento da doença periodontal. O estudo buscou analisar o uso de tetraciclina, amoxicilina e metronidazol, azitromicina, eritromicina e clindamicina sistêmicos como uso adjuvante do tratamento da doença periodontal. Apesar de ainda não haver um consenso quanto à dosagem, o intervalo entre as administrações e principalmente quanto ao tempo total do tratamento com antiinfecciosos sabe-se que estes são uma boa opção nos casos em que o tratamento periodontal convencional não consegue controlar a doença. Sendo apontado na literatura a associação de amoxicilina com metronidazol, e a tetraciclina como as melhores opções nesses casos. Palavras chave: doença periodontal; antibióticos; tratamento.The human mouth in physiology conditions, contains a large number of pathological and non-pathological bacteria. When there is an imbalance between the microbiota and host defenses can occur several diseases, including periodontal disease; an extremely common disease in the world population. Also known as periodontitis, it represents a group of inflammatory diseases of infectious and multifactorial origin which destroys tooth supporting tissues. The prevention and treatment of this disease are the subject of many studies because of its extreme importance in Public Health. Your treatment is based on scaling and root planing to open or closed field associated with the constant education of oral hygiene and patient motivation. This is the conventional periodontal therapy, which in most cases has successfully, however where periodontal disease does not regress, other treatment strategies are adopted, including adjunctive antibiotics. This study aimed to review the literature related to the systemic use of antibiotics in the treatment of periodontal disease. The study investigates the use of tetracycline, metronidazole and amoxicillin, azithromycin, erythromycin, and clindamycin as systemic adjunctive treatment of periodontal disease. Although there is still no consensus as to dosage, dosing interval and particularly for the total treatment time with anti-infective know that these are a good choice where conventional periodontal treatment can not control the disease. As pointed out in the literature the combination of amoxicillin and metronidazole, and tetracycline as the best options in such cases. Keywords: periodontal disease, antibiotic, treatment

    Mitochondrial physiology

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    As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

    Mitochondrial physiology

    Get PDF
    As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

    Search for dark matter produced in association with bottom or top quarks in √s = 13 TeV pp collisions with the ATLAS detector