39 research outputs found

    Business plan for a cultural platform

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    The business plan to be presented intends to support the development of a cultural platform that is built under three pivotal features: a broad cultural program, an accessible education component and a social dimension that strives for supporting immigrant communities. This project aspires to be a means of promotion of cultural diversity and cultural dialogue and to ultimately contribute to a better integration of immigrant communities within the Portuguese society. By developing this proposal, the author intends to present a business model that is sustainable and to subsequently eradicate the widespread notion that a cultural project never represents any return on investment. The underlying methodology comprehends the development of a theoretical context through a literature review, which was proceeded by a PESTEL and Porter analysis. An overview on the sector was performed, as well a review on the project’s competitive context. Additionally, the proposal involved the assessment of intrinsic opportunities and threats and the development of a survey that supported the STP and marketing mix strategies. After developing a systemic SWOT, a financial evaluation was conducted. This theoretical structure provided the conditions to conclude that there is an overall favorable environment that will most certainly allow the implementation of a project with the profile that was previously mentioned. Subsequently, this project is expected to generate an NPV of 1,1 million Euros and an IRR of 27%. The investment is predicted to be recovered in less than nine years and the project’s profitability index will represent 2,01 € per capital unit.O business plan desenvolvido tem como objetivo sustentar a criação de uma plataforma cultural, assente em três elementos principais: uma agenda cultural diversificada, uma componente educativa acessível e uma vertente social de apoio às comunidades imigrantes. Pretende-se que este projeto seja uma via promotora da diversidade e do diálogo cultural, contribuindo para a uma maior integração da comunidade imigrante na sociedade portuguesa. A concretização desta proposta reflete igualmente a intenção de apresentar um modelo de negócio sustentável, erradicando a noção generalizada de que um projeto cultural nunca poderá ter retorno sobre o investimento. A metodologia subjacente ao projeto compreende o desenvolvimento de uma contextualização teórica através de uma revisão de literatura, procedida de uma análise PESTEL e Porter. Seguidamente destacam-se a realização de uma avaliação ao setor cultural e recreativo e uma análise à concorrência. Adicionalmente, o desenvolvimento da proposta envolveu uma aferição das oportunidades e ameaças intrínsecas ao projeto e a elaboração de um questionário que sustenta a estratégia de STP e marketing mix. Após a execução de uma SWOT sistémica, procedeu-se ao desenvolvimento de uma avaliação financeira do projeto. Esta sistematização teórica permitiu concluir a existência de um ambiente favorável à implementação de um projeto nos moldes apresentados e a possibilidade do mesmo ter a capacidade de gerar um VAL correspondente a 1,1 milhões de euros e uma TIR de 27%. A recuperação do investimento será realizada em menos de nove anos e o índice de rendibilidade do projeto corresponderá a 2,01 € por unidade de capital investid

    Anti-SARS-CoV-2 inactivated vaccine in patients with ANCA-associated vasculitis: Immunogenicity, safety, antibody decay and the booster dose

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    Objective: To evaluate inactivated CoronaVac prime vaccination, antibody decay, booster dose, and safety in ANCA-Associated Vasculitis (AAV) patients. Methods: Fifty-three AAV patients and 106 Controls (CG) received CoronaVac on days: D0 (first dose), D28(second dose), and D210 (booster dose, 32 AAV: 32 CG). The primary outcome was immunogenicity after the second vaccine dose (day 69) assessed by Seroconversion Rates (SC) of anti-SARS-CoV-2 S1/S2 IgG and Neutralizing Antibodies (NAb). Secondary outcomes were safety, immunogenicity (D28/D240), 6-months antibody decay (D210) and the booster dose response (D240). Results: At D69 SC (65.1% vs. 96.8%, p = 0.0001), GMT (21.3 UA/mL vs. 67.7 UA/mL, p < 0.001) and NAb- positivity (53.7% vs. 80.6%, p = 0.001) were moderate but lower in naïve-AAV patients than CG. Patients without SC used more often IS (93.3% vs. 53.3%, p = 0.015), mycophenolate mofetil (20% vs. 0%, p = 0.037) and prednisone (60.0% vs. 28.6%, p = 0.057) than seroconverted. NAb negativity in AAV patients was associated with prednisone treatment (57.9% vs. 18.2%, p = 0.015) and IS (84.2% vs. 55.0%, p = 0.046). Logistic regression analysis models showed that only prednisone was associated with lower seroconversion (OR = 0.2, 0,95% CI 0.05‒0.86, p = 0.030) and with lower NAb positivity (OR = 0.2, 0,95% CI 0.05‒0.88, p = 0.034). After six months (D69‒D210) a decrease in IgG positivity occurred in 32 AAV patients (15.7%, p = 0.074) and 32 CG (18.7%, p = 0.041). For the NAb positivity, the 6-month decrease was not significant (p = 0.114) whereas a major reduction occurred for CG (p < 0.001). A booster dose (D240) resulted in an increment in IgG-positivity (21.9%, p = 0.023) and NAb-positivity (34.4%, p = 0.006) in AAV patients. No moderate/severe adverse events attributable to the vaccine were observed. Conclusion: This study provides novel data on the excellent safety and moderate immunogenicity of CoronaVac in AAV patients. A six-month mild antibody waning was observed with a good response to the booster dose, although levels remained lower than CG (CoronavRheum-NCT04754698)

    RECONSTRUÇÃO COM PRÓTESE BUCOMAXILOFACIAL EM PACIENTES ONCOLÓGICOS: SUA IMPORTÂNCIA NA ODONTOLOGIA

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    Facial maxillofacial prosthesis (P.B.M.F) is a specialty of dentistry responsible for oral, facial and functional rehabilitation with extraoral and intraoralintraoral prostheses of patients with maxillofacial defects. The shortage of specialized professionals is critical, as during the treatment of a malignant neoplasm, loss of facial structure may occur, where the specialized professional has the possibility of prosthetically rehabilitating the lost part, be it the eyeball, oculopalpebral, auricular, nasal, palate obturator aimed at improving the patient's self-esteem and social reintegration. Contact with the discipline is important for the evolution of the specialty, as well as the interest of undergraduates and students. P.B.M.F plays an important role in the social reintegration of a patient mutilated by oral neoplasia today. The advancement of aesthetic dentistry came with the need to enhance a more beautiful, harmonious and younger appearance of a patient who meets beauty standards. On the other hand, the patient with the loss of part of the face he fought for, with a diagnosis that threatened his life, seeks to become inconspicuous in the crowd. The objective of this work is to carry out a literature review exposing the need for professionals and academics to contact the P.B.M.F. and the types of prostheses used. The methodology was based on data taken from the Scielo, Pubmed and Google Scholar platforms over the last 10 years, with articles found that were mostly case reports. Maxillofacial prosthesis is a branch of dental prosthesis associated with the restoration and/or replacement of stomatognathic and craniofacial structures with prostheses, which may or may not be removed regularly or electively.A prótese bucomaxilofacial (P.B.M.F,) facial é uma especialidade da odontologia responsável pela reabilitação oral, facial e funcional com próteses extraorais e intra-oraisintraorais de pacientes com defeitos maxilofaciais. A escassez de profissionais especializados é crítica, pois durante um tratamento de uma neoplasia maligna pode ocorrer a perda de estrutura da face, onde o profissional especializado tem a possibilidade de reabilitar proteticamente a parte perdida seja ela de globo ocular, oculopalpebral, auricular, nasal, obturadora de palato visando a melhora da auto estima e a reintegração social do paciente. O contato com a disciplina é importante para a evolução da especialidade, assim como interesse de graduandos e discentes. A P.B.M.F tem um papel importante na reintegração social de um paciente mutilado pela neoplasia bucal nos dias de hoje. O avanço da odontologia estética veio com a necessidade de se enaltecer uma aparência mais bela, harmoniosa e mais jovem de um paciente que se enquadra nos padrões de beleza. Em contrapartida, o paciente com perda de parte da face que lutou, com um diagnóstico que ameaçou sua vida, busca se tornar imperceptível no meio da multidão. O objetivo deste trabalho é realizar uma revisão de literatura expondo a necessidade do contato dos profissionais e acadêmicos com a P.B.M.F.  e os tipos de próteses usadas. A metodologia se baseou em dados retirados das plataformas Scielo, Pubmed e Google Acadêmico dos últimos 10 anos, sendo encontrados artigos que na sua maioria eram relatos de caso. A prótese maxilofacial é um ramo da prótese dentária associada à restauração e/ou substituição de estruturas estomatognáticas e craniofaciais por próteses, que podem ou não ser removidas de forma regular ou eletiva

    VIVÊNCIAS NO ESTÁGIO SUPERVISIONADO EM SETOR CLÍNICO DE ENDOSCOPIA E COLONOSCOPIA – RELATO DE EXPERIÊNCIA.

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    Introduction: The study of upper digestive endoscopy (EDA) and colonoscopy are exams that have improved with advances in global technologies. They serve as a basis for diagnosing basic diseases of the digestive system, with high prevalence and mortality in the world. The non-mandatory internship chosen in this area of knowledge aims to learn and develop clinical skills with the aim of improving the medical academic curriculum and exposing the activity as an experience report to the scientific community. Method: descriptive, longitudinal study, carried out in the first half of 2023 in a private clinic in Belém do Pará, where the intern presents its advantages and difficulties when carrying out the procedure. Results: the confluence between the curriculum and practical internship activities proved to be productive, in accordance with the objectives of the study and a new clinical experience for the academic. Conclusion: the active methodology of the medical course was passed on to the scientific community, where placing students in direct contact with care in an uncontrolled environment is essential to their training.  Introdução: O estudo da endoscopia digestiva alta (EDA) e colonoscopia, são exames que se aprimoraram com os avanços das tecnologias mundiais. Servem de base ao diagnóstico de doenças bases do sistema digestório, de alta prevalência e mortalidade no mundo. O estágio não obrigatório escolhido nesta área do conhecimento visa aprender e desenvolver habilidades clínicas com o intuito melhor o currículo acadêmico médico e expor a atividade como relato de experiência a comunidade científica. Método: estudo descritivo, longitudinal, realizado no primeiro semestre de 2023 em uma clínica particular em Belém do Pará, onde o estagiário apresenta suas vantagens e dificuldades ao realiza-lo. Resultados: a confluência entre grade curricular e atividades prática em estágio mostraram-se produtiva, de acordo com os objetivos do estudo e uma nova experiência clínica ao acadêmico. Conclusão: repassado a comunidade científica a metodologia ativa do curso de medicina onde colocar os alunos em contato direto com o atendimento em um ambiente não controlado é essencial a sua formação.   &nbsp

    Pervasive gaps in Amazonian ecological research

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    Pervasive gaps in Amazonian ecological research

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    Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

    Mitochondrial physiology

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    As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery

    Mitochondrial physiology

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    As the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery
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