Dark energy in light of the early JWST observations: case for a negative cosmological constant?

Early data from the James Webb Space Telescope (JWST) has uncovered the existence of a surprisingly abundant population of very massive galaxies at extremely high redshift, which are hard to accommodate within the standard $\Lambda$CDM cosmology. We explore whether the JWST observations may be pointing towards more complex dynamics in the dark energy (DE) sector. Motivated by the ubiquity of anti-de Sitter vacua in string theory, we consider a string-inspired scenario where the DE sector consists of a negative cosmological constant (nCC) and a evolving component with positive energy density on top, whose equation of state is allowed to cross the phantom divide. We show that such a scenario can drastically alter the growth of structure compared to $\Lambda$CDM, and accommodate the otherwise puzzling JWST observations if the dynamical component evolves from the quintessence-like regime in the past to the phantom regime today: in particular, we demonstrate that the presence of a nCC (which requires a higher density for the evolving component) plays a crucial role in enhancing the predicted cumulative comoving stellar mass density. Our work reinforces the enormous potential held by observations of the abundance of high-$z$ galaxies in probing cosmological models and new fundamental physics, including string-inspired ingredients.Comment: 30 pages, 10 sub-figures arranged into 5 figures. v2: additional references added, acknowledgements updated. v3: added two sub-figures (one additional figure) and additional references. Version accepted for publication in JCA

Loss of Gata6 causes dilation of the hair follicle canal and sebaceous duct

The uppermost aspect of the hair follicle, known as the infundibulum or hair canal, provides a passageway for hair shaft egress and sebum secretion. Recent studies have indicated that the infundibulum and sebaceous ducts are lined by molecularly distinct differentiated cells expressing markers including Keratin 79 and Gata6. Here, we ablated Gata6 from the skin and observed dilation of both the hair canal and sebaceous ducts, independent of gender and hair cycle stage. Constitutive loss of Gata6 yielded only a mild delay in depilation‐induced entry into anagen, while unperturbed mutant mice possessed overtly normal skin and hair. Furthermore, we noted that Keratin 79 and Gata6 expression and localization did not depend upon each other. Our findings implicate Gata6 in maintaining the upper hair follicle and suggest that regulation of this transcription factor may be compromised in pathologies such as acne or infundibular cystic diseases that are characterized by abnormal expansion of this follicular domain.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149235/1/exd13757_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149235/2/exd13757-sup-0001-FigS1-S9.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/149235/3/exd13757.pd

The state of the dark energy equation of state circa 2023

We critically examine the state of current constraints on the dark energy (DE) equation of state (EoS) $w$. Our study is partially motivated by the observation that, while broadly consistent with the cosmological constant value $w=-1$, several independent probes appear to point towards a slightly phantom EoS ($w \sim -1.03$). We pay attention to the apparent preference for phantom DE from Planck Cosmic Microwave Background (CMB) data alone, whose origin we study in detail and attribute to a wide range of (physical and geometrical) effects. We deem the combination of Planck CMB, Baryon Acoustic Oscillations, Type Ia Supernovae, and Cosmic Chronometers data to be particularly trustworthy, inferring from this final consensus dataset $w=-1.013^{+0.038}_{-0.043}$, in excellent agreement with the cosmological constant value. Overall, despite a few scattered hints, we find no compelling evidence forcing us away from the cosmological constant (yet).Comment: 21 pages, 10 figures, 3 table

MDA, oxypurines, and nucleosides relate to reperfusion in short-term incomplete cerebral ischemia in the rat

Short-term incomplete cerebral ischemia (5 min) was induced in the rat by the bilateral clamping of the common carotid arteries. Reperfusion was obtained by removing carotid clamping and was carried out for the following 10 min. Animals were sacrificed either at the end of ischemia or reperfusion. Controls were represented by a group of sham-operated rats. Peripheral venous blood samples were withdrawn from the femoral vein from rats subjected to cerebral reperfusion 5 min before ischemia, at the end of ischemia, and 10 min after reperfusion. Neutralized perchloric acid extracts of brain tissue were analyzed by a highly sensitive high-performance liquid chromatography (HPLC) method for the direct determination of malondialdehyde, oxypurines, nucleosides, nicotinic coenzymes, and high-energy phosphates. In addition, plasma concentrations of malondialdehyde, hypoxanthine, xanthine, inosine, uric acid, and adenosine were determined by the same HPLC technique. Incomplete cerebral ischemia induced the appearance of a significant amount (8.05 nmol/g w.w.; SD = 2.82) of cerebral malondialdehyde (which was undetectable in control animals) and a decrease of ascorbic acid. A further 6.6-fold increase of malondialdehyde (53.30 nmol/g w.w.; SD = 17.77) and a 18.5% decrease of ascorbic acid occurred after 10 min of reperfusion. Plasma malondialdehyde, which was present in minimal amount before ischemia (0.050 mumol/L; SD = 0.015), significantly increased after 5 min of ischemia (0.277 mumol/L; SD = 0.056) and was strikingly augmented after 10 min of reperfusion (0.682 mumol/L; SD = 0.094). A similar trend was observed for xanthine, uric acid, inosine, and adenosine, while hypoxanthine reached its maximal concentration after 5 min of incomplete ischemia, being significantly decreased after reperfusion. From the data obtained, it can be concluded that tissue concentrations of malondialdehyde and ascorbic acid, and plasma levels of malondialdehyde, oxypurines, and nucleosides, reflect both the oxygen radical-mediated tissue injury and the depression of energy metabolism, thus representing early biochemical markers of short-term incomplete brain ischemia and reperfusion in the rat. In particular, these results suggest the possibility of using the variation of malondialdehyde, oxypurines, and nucleosides in peripheral blood as a potential biochemical indicator of reperfusion damage occurring to postischemic tissues

Decrease in n-acetylaspartate following concussion may be coupled to decrease in creatine

Objectives: To assess the time course changes in brain N-acetylaspartate (NAA) and creatine (Cr) in athletes who suffered a sport-related concussion. Participants: Eleven non-consecutive concussed athletes and 11 sex and age-matched control volunteers. Main outcome measures: At 3, 15, 30 and 45 days post-injury, athletes were examined by proton Magnetic Resonance Spectroscopy (1H-MRS) for the determination of NAA,(Cr) and choline (Cho). 1H-MRS data recorded in the control group were used for comparison. Results: Compared to controls (2.18 ± 0.19), athletes showed an NAA/Cr increase at 3 (2.71 ± 0.16; p < 0.01) and 15 days (2.54 ± 0.21; p < 0.01), followed by a decrease and subsequent normalization at 30 (1.95 ± 0.16, p < 0.05) and 45 days(2.17 ± 0.20; p <0.05) post-concussion. NAA/Cho decreased at 3, 15 and 30 days post-injury (p < 0.01 compared to controls), with no differences from controls at 45 days post-concussion. Significant increase in the Cho/Cr after 3 (+33%, p < 0.01) and 15 (+31.5%, p < 0.01) days post-injury was observed, whilst no differences compared to controls were recorded at 30 and 45 days post-impact. Conclusions: This cohort of athletes indicates that concussion may cause concomitant decrease in cerebral NAA and Cr. This occurrence provokes longer time of metabolism normalization, as well as longer resolution time of concussion-associated clinical symptoms

Formation of a disk structure in the symbiotic binary AX Per during its 2007-10 precursor-type activity

AX Per is an eclipsing symbiotic binary. During active phases, deep narrow minima are observed in its light curve, and the ionization structure in the binary changes significantly. From 2007.5, AX Per entered a new active phase. It was connected with a significant enhancement of the hot star wind. Simultaneously, we identified a variable optically thick warm (Teff ~ 6000 K) source that contributes markedly to the composite spectrum. The source was located at the hot star's equator and has the form of a flared disk, whose outer rim simulates the warm photosphere. The formation of the neutral disk-like zone around the accretor during the active phase was connected with its enhanced wind. We suggested that this connection represents a common origin of the warm pseudophotospheres that are indicated during the active phases of symbiotic stars.Comment: 13 pages, 9 figures, 8 tables, accepted for A&

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

© 2018 Academic Press. All rights reserved. Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate acute wound healing and long-term tissue remodeling with scarring. With myocardial infarction injury, cardiomyocytes are replaced by secreted extracellular matrix proteins produced by proliferating and differentiating fibroblasts. Here, we employed 3 different mouse lineage-tracing models and stage-specific gene profiling to phenotypically analyze and classify resident cardiac fibroblast dynamics during myocardial infarction injury and stable scar formation. Fibroblasts were activated and highly proliferative, reaching a maximum rate within 2 to 4 days after infarction injury, at which point they expanded 3.5-fold and were maintained long term. By 3 to 7 days, these cells differentiated into myofibroblasts that secreted abundant extracellular matrix proteins and expressed smooth muscle α-actin to structurally support the necrotic area. By 7 to 10 days, myofibroblasts lost proliferative ability and smooth muscle α-actin expression as the collagen-containing extracellular matrix and scar fully matured. However, these same lineage-traced initial fibroblasts persisted within the scar, achieving a new molecular and stable differentiated state referred to as a matrifibrocyte, which was also observed in the scars of human hearts. These cells express common and unique extracellular matrix and tendon genes that are more specialized to support the mature scar