A Growing Conjunctival Pigmentation – Videodermoscopy of Conjunctival Melanoma

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An Atypical Presentation of Extragenital Lichen Sclerosus et Atrophicus

open6noLichen Sclerosus et Atrophicus is a chronic inflammatory,invalidating disorder mainly involving the anogenital skin. Extragenital lesions are uncommon, occurring asmultiple, oval, porcelain-white macules, or papules. Whenpresent, they are mostly observed on the superior trunk, axillae, buttocks, and extremities, following Blaschko lines.openSabina Vaccari, Alessia Barisani, Francesca Pepe, Carlotta Baraldi, Bianca Maria Piraccini, Valeria GaspariSabina Vaccari, Alessia Barisani, Francesca Pepe, Carlotta Baraldi, Bianca Maria Piraccini, Valeria Gaspar

Frequency of malignant neoplasms in 257 chronic leg ulcers

none7noBACKGROUND: Chronic leg ulcers are one of the most common medical conditions and are a substantial source of morbidity. OBJECTIVES: To investigate the prevalence of skin cancer mimicking leg ulcers. PATIENTS AND METHODS: This observational study included all patients with a clinical diagnosis of chronic leg ulcers (CLU) admitted to the Wound Care Unit, Division of Dermatology, University of Bologna, between March 2008 and February 2011. Patients' general health was assessed, and skin biopsy and vascular Doppler of the lower limbs were performed. RESULTS: Two hundred fifty-seven patients ages 45 to 98 with CLU were included. Skin biopsies were performed in all patients. Pathologic results showed that 10 patients had ulcerative lesions of neoplastic origin. Surgical excision was performed in all patients with neoplasms. After at least 1 year of follow-up, no recurrences were observed. DISCUSSION AND CONCLUSION: Our findings highlight the important role of systematic biopsies in diagnosing ulcerated tumors of the lower legs and indicate a high prevalence of large ulcerated basal cell carcinomas.Background Chronic leg ulcers are one of the most common medical conditions and are a substantial source of morbidity. Objectives To investigate the prevalence of skin cancer mimicking leg ulcers. Patients and Methods This observational study included all patients with a clinical diagnosis of chronic leg ulcers (CLU) admitted to the Wound Care Unit, Division of Dermatology, University of Bologna, between March 2008 and February 2011. Patients' general health was assessed, and skin biopsy and vascular Doppler of the lower limbs were performed. Results Two hundred fifty-seven patients ages 45 to 98 with CLU were included. Skin biopsies were performed in all patients. Pathologic results showed that 10 patients had ulcerative lesions of neoplastic origin. Surgical excision was performed in all patients with neoplasms. After at least 1 year of follow-up, no recurrences were observed. Discussion and Conclusion Our findings highlight the important role of systematic biopsies in diagnosing ulcerated tumors of the lower legs and indicate a high prevalence of large ulcerated basal cell carcinomas. © 2013 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.openMisciali C;Dika E;Fanti PA;Vaccari S;Baraldi C;Sgubbi P;Patrizi AMisciali C;Dika E;Fanti PA;Vaccari S;Baraldi C;Sgubbi P;Patrizi

Does the molecular and metabolic profile of human granulosa cells correlate with oocyte fate? New insights by Fourier transform infrared microspectroscopy analysis

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The star-formation rate density from z = 1 to 6

We use 3035 Herschel-SPIRE 500 μm sources from 20.3 deg² of sky in the HerMES Lockman, ES1 and XMM-LSS areas to estimate the star formation rate density at z = 0–6. 500 μm sources are associated first with 350 and 250 μm sources, and then with Spitzer 24 μm sources from the SWIRE photometric redshift catalogue. The infrared and submillimetre data are fitted with a set of radiative-transfer templates corresponding to cirrus (quiescent) and starburst galaxies. Lensing candidates are removed via a set of colour–colour and colour–redshift constraints. Star formation rates are found to extend from <1 to 20 000 M⊙ yr−1. Such high values were also seen in the all-sky IRAS Faint Source Survey. Star formation rate functions are derived in a series of redshift bins from 0 to 6, combined with earlier far-infrared estimates, where available, and fitted with a Saunders et al (1990) functional form. The star formation rate density as a function of redshift is derived and compared with other estimates. There is reasonable agreement with both infrared and ultraviolet estimates for z < 3, but we find higher star formation rate densities than ultraviolet estimates at z = 3–6. Given the considerable uncertainties in the submillimetre estimates, we cannot rule out the possibility that the ultraviolet estimates are correct. But the possibility that the ultraviolet estimates have seriously underestimated the contribution of dust-shrouded star formation can also not be excluded

Assessment of copy number variations in 120 patients with Poland syndrome

Poland Syndrome (PS) is a rare congenital disorder presenting with agenesis/hypoplasia of the pectoralis major muscle variably associated with thoracic and/or upper limb anomalies. Most cases are sporadic, but familial recurrence, with different inheritance patterns, has been observed. The genetic etiology of PS remains unknown. Karyotyping and array-comparative genomic hybridization (CGH) analyses can identify genomic imbalances that can clarify the genetic etiology of congenital and neurodevelopmental disorders. We previously reported a chromosome 11 deletion in twin girls with pectoralis muscle hypoplasia and skeletal anomalies, and a chromosome six deletion in a patient presenting a complex phenotype that included pectoralis muscle hypoplasia. However, the contribution of genomic imbalances to PS remains largely unknown

The European Large Area ISO Survey IX: the 90 micron luminosity function from the Final Analysis sample

We present the 90 micron luminosity function of the Final Analysis of the European Large Area ISO Survey (ELAIS), extending the sample size of our previous analysis (paper IV) by about a factor of 4. Our sample extends to z=1.1, around 50 times the comoving volume of paper IV, and 10^{7.7} < h^{-2}L/Lsun < 10^{12.5}. From our optical spectroscopy campaigns of the northern ELAIS 90 mircon survey (7.4 deg^2 in total, to S(90um)>70mJy), we obtained redshifts for 61% of the sample (151 redshifts) to B<21 identified at 7 microns, 15 microns, 20cm or with bright (B<18.5) optical identifications. The selection function is well-defined, permitting the construction of the 90 micron luminosity function of the Final Analysis catalogue in the ELAIS northern fields, which is in excellent agreement with our Preliminary Analysis luminosity function in the ELAIS S1 field from paper IV. The luminosity function is also in good agreement with the IRAS-based prediction of Serjeant & Harrison (2004), which if correct requires luminosity evolution of (1+z)^{3.4 +/- 1.0} for consistency with the source counts. This implies an evolution in comoving volume averaged star formation rate at z<~1 consistent with that derived from rest-frame optical and ultraviolet surveys.Comment: MNRAS accepted. 7 pages, 5 figures. Uses BoxedEPS (included

The Herschel* PEP-HERMES Luminosity Function- I. Probing the Evolution of PACS Selected Galaxies to z approx. equal to 4

We exploit the deep and extended far-IR data sets (at 70, 100 and 160 m) of the Herschel Guaranteed Time Observation (GTO) PACS Evolutionary Probe (PEP) Survey, in combination with the Herschel Multi-tiered Extragalactic Survey data at 250, 350 and 500 m, to derive the evolution of the rest-frame 35-, 60-, 90- and total infrared (IR) luminosity functions (LFs) up to z 4.We detect very strong luminosity evolution for the total IR LF (LIR (1 + z)(sup 3.55 +/- 0.10) up to z 2, and (1 + z)(sup 1.62 +/- 0.51) at 2 less than z less than approximately 4) combined with a density evolution ( (1 + z)(sup 0.57 +/- 0.22) up to z 1 and (1 + z)(sup 3.92 +/- 0.34) at 1 less than z less than approximately 4). In agreement with previous findings, the IR luminosity density (IR) increases steeply to z 1, then flattens between z 1 and z 3 to decrease at z greater than approximately 3. Galaxies with different spectral energy distributions, masses and specific star formation rates (SFRs) evolve in very different ways and this large and deep statistical sample is the first one allowing us to separately study the different evolutionary behaviours of the individual IR populations contributing to IR. Galaxies occupying the well-established SFR-stellar mass main sequence (MS) are found to dominate both the total IR LF and IR at all redshifts, with the contribution from off-MS sources (0.6 dex above MS) being nearly constant (20 per cent of the total IR) and showing no significant signs of increase with increasing z over the whole 0.8 < z <2.2 range. Sources with mass in the range 10 log(M/solar mass) 11 are found to dominate the total IR LF, with more massive galaxies prevailing at the bright end of the high-z (greater than approximately 2) LF. A two-fold evolutionary scheme for IR galaxies is envisaged: on the one hand, a starburst-dominated phase in which the Super Massive Black Holes (SMBH) grows and is obscured by dust (possibly triggered by a major merging event), is followed by an AGN-dominated phase, then evolving towards a local elliptical. On the other hand, moderately star-forming galaxies containing a low-luminosity AGN have various properties suggesting they are good candidates for systems in a transition phase preceding the formation of steady spiral galaxies