Tracing planet-induced structures in circumstellar disks using molecular lines

Circumstellar disks are considered to be the birthplace of planets. Specific structures like spiral arms, gaps, and cavities are characteristic indicators of planet-disk interaction. Investigating these structures can provide insights into the growth of protoplanets and the physical properties of the disk. We investigate the feasibility of using molecular lines to trace planet-induced structures in circumstellar disks. Based on 3D hydrodynamic simulations of planet-disk interactions, we perform self-consistent temperature calculations and produce N-LTE molecular line velocity-channel maps and spectra of these disks using our new N-LTE line radiative transfer code Mol3D. Subsequently, we simulate ALMA observations using the CASA simulator. We consider two nearly face-on inclinations, 5 disk masses, 7 disk radii, and 2 different typical pre-main-sequence host stars (T Tauri, Herbig Ae). We calculate up to 141 individual velocity-channel maps for five molecules/isotopoloques in a total of 32 rotational transitions to investigate the frequency dependence of the structures indicated above. We find that the majority of protoplanetary disks in our parameter space could be detected in the molecular lines considered. However, unlike the continuum case, gap detection is not straightforward in lines. For example, gaps are not seen in symmetric rings but are masked by the pattern caused by the global (Keplerian) velocity field. We identify specific regions in the velocity-channel maps that are characteristic of planet-induced structures. Simulations of high angular resolution molecular line observations demonstrate the potential of ALMA to provide complementary information about the planet-disk interaction as compared to continuum observations. In particular, the detection of planet-induced gaps is possible under certain conditions.(abridged)Comment: 19 pages, 19 figures, accepted for publication in A&

Trapping dust particles in the outer regions of protoplanetary disks

Aims. We attempt to explain grain growth to mm sized particles and their retention in the outer regions of protoplanetary disks, as observed at sub-mm and mm wavelengths, by investigating whether strong inhomogeneities in the gas density profiles can decelerate excessive radial drift and help the dust particles to grow. Methods. We use coagulation/fragmentation and disk-structure models, to simulate the evolution of dust in a bumpy surface density profile, which we mimic with a sinusoidal disturbance. For different values of the amplitude and length scale of the bumps, we investigate the ability of this model to produce and retain large particles on million-year timescales. In addition, we compare the pressure inhomogeneities considered in this work with the pressure profiles that come from magnetorotational instability. Using the Common Astronomy Software Applications ALMA simulator, we study whether there are observational signatures of these pressure inhomogeneities that can be seen with ALMA. Results. We present the conditions required to trap dust particles and the corresponding calculations predicting the spectral slope in the mm-wavelength range, to compare with current observations. Finally, we present simulated images using different antenna configurations of ALMA at different frequencies, to show that the ring structures will be detectable at the distances of either the Taurus Auriga or Ophiucus star-forming regions

Evidence for spin-triplet superconducting correlations in metal-oxide heterostructures with non-collinear magnetization

Heterostructures composed of ferromagnetic La0.7Sr0.3MnO3, ferromagnetic SrRuO3, and superconducting YBa2Cu3Ox were studied experimentally. Structures of composition Au/La0.7Sr0.3MnO3/SrRuO3/YBa2Cu3Ox were prepared by pulsed laser deposition, and their high quality was confirmed by X-ray diffraction and reflectometry. A non-collinear magnetic state of the heterostructures was revealed by means of SQUID magnetometry and polarized neutron reflectometry. We have further observed superconducting currents in mesa-structures fabricated by deposition of a second superconducting Nb layer on top of the heterostructure, followed by patterning with photolithography and ion-beam etching. Josephson effects observed in these mesa-structures can be explained by the penetration of a triplet component of the superconducting order parameter into the magnetic layers.Comment: 10 pages, 6 figure

Micromachined Oblique Incidence Refleciometry (OIR) Probe for Skin Cancer Detection

We present the design, fabrication and in-vivo testing of a new micromachined probe for skin cancer detection based on oblique incidence reflectometry (OIR). The device miniaturization and fabrication precision provided by micromachining ensure reliable and repeatable high performance of the probe. The developed probe has been tested in a pre-clinical condition. An overall sensitivity of 100% and specificity of 93% haven been achieved in the classification of malignant and benign skin lesions

Legendrian Distributions with Applications to Poincar\'e Series

Let $X$ be a compact Kahler manifold and $L\to X$ a quantizing holomorphic Hermitian line bundle. To immersed Lagrangian submanifolds $\Lambda$ of $X$ satisfying a Bohr-Sommerfeld condition we associate sequences $\{ |\Lambda, k\rangle \}_{k=1}^\infty$, where $\forall k$ $|\Lambda, k\rangle$ is a holomorphic section of $L^{\otimes k}$. The terms in each sequence concentrate on $\Lambda$, and a sequence itself has a symbol which is a half-form, $\sigma$, on $\Lambda$. We prove estimates, as $k\to\infty$, of the norm squares $\langle \Lambda, k|\Lambda, k\rangle$ in terms of $\int_\Lambda \sigma\overline{\sigma}$. More generally, we show that if $\Lambda_1$ and $\Lambda_2$ are two Bohr-Sommerfeld Lagrangian submanifolds intersecting cleanly, the inner products $\langle\Lambda_1, k|\Lambda_2, k\rangle$ have an asymptotic expansion as $k\to\infty$, the leading coefficient being an integral over the intersection $\Lambda_1\cap\Lambda_2$. Our construction is a quantization scheme of Bohr-Sommerfeld Lagrangian submanifolds of $X$. We prove that the Poincar\'e series on hyperbolic surfaces are a particular case, and therefore obtain estimates of their norms and inner products.Comment: 41 pages, LaTe

Boundedness of Pseudodifferential Operators on Banach Function Spaces

We show that if the Hardy-Littlewood maximal operator is bounded on a separable Banach function space $X(\mathbb{R}^n)$ and on its associate space $X'(\mathbb{R}^n)$, then a pseudodifferential operator $\operatorname{Op}(a)$ is bounded on $X(\mathbb{R}^n)$ whenever the symbol $a$ belongs to the H\"ormander class $S_{\rho,\delta}^{n(\rho-1)}$ with $0<\rho\le 1$, $0\le\delta<1$ or to the the Miyachi class $S_{\rho,\delta}^{n(\rho-1)}(\varkappa,n)$ with $0\le\delta\le\rho\le 1$, $0\le\delta0$. This result is applied to the case of variable Lebesgue spaces $L^{p(\cdot)}(\mathbb{R}^n)$.Comment: To appear in a special volume of Operator Theory: Advances and Applications dedicated to Ant\'onio Ferreira dos Santo

3D MHD Simulations of Planet Migration in Turbulent Stratified Disks

We performed 3D MHD simulations of planet migration in stratified disks using the Godunov code PLUTO, where the disk is turbulent due to the magnetorotational instability. We study the migration for planets with different planet-star mass ratios $q=M_{p}/M_{s}$. In agreement with previous studies, for the low-mass planet cases ($q=5\times10^{-6}$ and $10^{-5}$), migration is dominated by random fluctuations in the torque. For a Jupiter-mass planet $(q=M_{p}/M_{s}=10^{-3}$ for $M_{s}=1M_{\odot})$, we find a reduction of the magnetic stress inside the orbit of the planet and around the gap region. After an initial stage where the torque on the planet is positive, it reverses and we recover migration rates similar to those found in disks where the turbulent viscosity is modelled by an $\alpha$ viscosity. For the intermediate-mass planets ($q=5\times10^{-5}, 10^{-4}$ and $2\times10^{-4}$) we find a new and so far unexpected behavior. In some cases they experience sustained and systematic outwards migration for the entire duration of the simulation. For this case, the horseshoe region is resolved and torques coming from the corotation region can remain unsaturated due to the stresses in the disk. These stresses are generated directly by the magnetic field. The magnitude of the horseshoe drag can overcome the negative Lindblad contribution when the local surface density profile is flat or increasing outwards, which we see in certain locations in our simulations due to the presence of a zonal flow. The intermediate-mass planet is migrating radially outwards in locations where there is a positive gradient of a pressure bump (zonal flow).Comment: Accepted for publication in Ap

Nonlinear viscosity and velocity distribution function in a simple longitudinal flow

A compressible flow characterized by a velocity field $u_x(x,t)=ax/(1+at)$ is analyzed by means of the Boltzmann equation and the Bhatnagar-Gross-Krook kinetic model. The sign of the control parameter (the longitudinal deformation rate $a$) distinguishes between an expansion ($a>0$) and a condensation ($a<0$) phenomenon. The temperature is a decreasing function of time in the former case, while it is an increasing function in the latter. The non-Newtonian behavior of the gas is described by a dimensionless nonlinear viscosity $\eta^*(a^*)$, that depends on the dimensionless longitudinal rate $a^*$. The Chapman-Enskog expansion of $\eta^*$ in powers of $a^*$ is seen to be only asymptotic (except in the case of Maxwell molecules). The velocity distribution function is also studied. At any value of $a^*$, it exhibits an algebraic high-velocity tail that is responsible for the divergence of velocity moments. For sufficiently negative $a^*$, moments of degree four and higher may diverge, while for positive $a^*$ the divergence occurs in moments of degree equal to or larger than eight.Comment: 18 pages (Revtex), including 5 figures (eps). Analysis of the heat flux plus other minor changes added. Revised version accepted for publication in PR

Reconstitution of T cell receptor signaling in ZAP-70-deficient cells by retroviral transduction of the ZAP-70 gene.

A variant of severe combined immunodeficiency syndrome (SCID) with a selective inability to produce CD8 single positive T cells and a signal transduction defect in peripheral CD4+ cells has recently been shown to be the result of mutations in the ZAP-70 gene. T cell receptor (TCR) signaling requires the association of the ZAP-70 protein tyrosine kinase with the TCR complex. Human T cell leukemia virus type I-transformed CD4+ T cell lines were established from ZAP-70-deficient patients and normal controls. ZAP-70 was expressed and appropriately phosphorylated in normal T cell lines after TCR engagement, but was not detected in T cell lines from ZAP-70-deficient patients. To determine whether signaling could be reconstituted, wild-type ZAP-70 was introduced into deficient cells with a ZAP-70 retroviral vector. High titer producer clones expressing ZAP-70 were generated in the Gibbon ape leukemia virus packaging line PG13. After transduction, ZAP-70 was detected at levels equivalent to those observed in normal cells, and was appropriately phosphorylated on tyrosine after receptor engagement. The kinase activity of ZAP-70 in the reconstituted cells was also appropriately upregulated by receptor aggregation. Moreover, normal and transduced cells, but not ZAP-70-deficient cells, were able to mobilize calcium after receptor ligation, indicating that proximal TCR signaling was reconstituted. These results indicate that this form of SCID may be corrected by gene therapy

Tracking neural crest cell cycle progression in vivo

Analysis of cell cycle entry/exit and progression can provide fundamental insights into stem cell propagation, maintenance, and differentiation. The neural crest is a unique stem cell population in vertebrate embryos that undergoes long‐distance collective migration and differentiation into a wide variety of derivatives. Using traditional techniques such as immunohistochemistry to track cell cycle changes in such a dynamic population is challenging, as static time points provide an incomplete spatiotemporal picture. In contrast, the fluorescent, ubiquitination‐based cell cycle indicator (Fucci) system provides in vivo readouts of cell cycle progression and has been previously adapted for use in zebrafish. The most commonly used Fucci systems are ubiquitously expressed, making tracking of a specific cell population challenging. Therefore, we generated a transgenic zebrafish line, Tg(‐4.9sox10:mAG‐gmnn(1/100)‐2A‐mCherry‐cdt1(1/190)), in which the Fucci system is specifically expressed in delaminating and migrating neural crest cells. Here, we demonstrate validation of this new tool and its use in live high‐resolution tracking of cell cycle progression in the neural crest and derivative populations