Topology change in commuting saddles of thermal N=4 SYM theory

We study the large N saddle points of weakly coupled N=4 super Yang-Mills theory on S^1 x S^3 that are described by a commuting matrix model for the seven scalar fields {A_0, \Phi_J}. We show that at temperatures below the Hagedorn/`deconfinement' transition the joint eigenvalue distribution is S^1 x S^5. At high temperatures T >> 1/R_{S^3}, the eigenvalues form an ellipsoid with topology S^6. We show how the deconfinement transition realises the topology change S^1 x S^5 --> S^6. Furthermore, we find compelling evidence that when the temperature is increased to T = 1/(\sqrt\lambda R_{S^3}) the saddle with S^6 topology changes continuously to one with S^5 topology in a new second order quantum phase transition occurring in these saddles.Comment: 1+40 pages, 6 figures. v2: Title changed. Status of commuting saddles clarified: New high T phase transition claimed in the commuting sector only, not in the full theor

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Making public policy in 19th century Britain

Inaugural lecture delivered 24 Nov 1997SIGLEAvailable from British Library Document Supply Centre-DSC:98/11784 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

IT in manufacturing The map to a new society; inaugural lecture

Available from British Library Document Supply Centre- DSC:89/13902(IT) / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

Democracy, freedom and special rights

John C. Rees memorial lecture delivered Swansea (GB), 30 JanSIGLEAvailable from British Library Document Supply Centre-DSC:96/14217 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Nuclear ethics, realism and utopianism The 'permanent dialogue' revisited : inaugural lecture : 21 October 2002

Available from British Library Document Supply Centre- DSC:m03/15008 / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

Towards a parliament Three faces of the National Assembly for Wales

O'Donnell lecture, 18th February, 2002, Taliesin Arts TheatreSIGLEAvailable from British Library Document Supply Centre-DSC:m02/21655 / BLDSC - British Library Document Supply CentreGBUnited Kingdo