Mitigating Temporal Fragility in the XY Surface Code

An important outstanding challenge that must be overcome in order to fully utilize the XY surface code for correcting biased Pauli noise is the phenomena of fragile temporal boundaries that arise during the standard logical state preparation and measurement protocols. To address this challenge we propose a new logical state preparation protocol based on locally entangling qubits into small Greenberger-Horne-Zeilinger-like states prior to making the stabilizer measurements that place them in the XY-code state. We prove that in this new procedure $O(\sqrt{n})$ high-rate errors along a single lattice boundary can cause a logical failure, leading to an almost quadratic reduction in the number of fault-configurations compared to the standard state-preparation approach. Moreover, the code becomes equivalent to a repetition code for high-rate errors, guaranteeing a 50% code-capacity threshold during state preparation for infinitely biased noise. With a simple matching decoder we confirm that our preparation protocol outperforms the standard one in terms of both threshold and logical error rate in the fault-tolerant regime where measurements are unreliable and at experimentally realistic biases. We also discuss how our state-preparation protocol can be inverted for similar fragile-boundary-mitigated logical-state measurement.Comment: 9 pages, 9 figure

MIMO Evolution toward 6G: End-User-Centric Collaborative MIMO

In 6G, the trend of transitioning from massive antenna elements to even more massive ones is continued. However, installing additional antennas in the limited space of user equipment (UE) is challenging, resulting in limited capacity scaling gain for end users, despite network side support for increasing numbers of antennas. To address this issue, we propose an end-user-centric collaborative MIMO (UE-CoMIMO) framework that groups several fixed or portable devices to provide a virtual abundance of antennas. This article outlines how advanced L1 relays and conventional relays enable device collaboration to offer diversity, rank, and localization enhancements. We demonstrate through system-level simulations how the UE-CoMIMO approaches lead to significant performance gains. Lastly, we discuss necessary research efforts to make UE-CoMIMO available for 6G and future research directions.Comment: 7 pages, 5 figures, 1 table. This work has been accepted in IEEE Communications Magazin

Shaping a Smarter Electromagnetic Landscape: IAB, NCR, and RIS in 5G Standard and Future 6G

The main objective of 5G and beyond networks is to provide an optimal user experience in terms of throughput and reliability, irrespective of location and time. To achieve this, traditional fixed macro base station deployments are being replaced by more innovative and flexible solutions, such as wireless backhaul and relays. This article focuses on the evolution and standardization of these advancements, which are shaping the electromagnetic landscape. Specifically, we explore Integrated Access and Backhaul (IAB) nodes, which offer a cost-efficient and agile alternative to fiber backhaul. We also discuss Network-Controlled Repeaters (NCRs) and the emergence of Reconfigurable Intelligent Surfaces (RIS) actively adapting the wireless environment. The article provides an overview of the 5G features and ongoing developments in 3GPP Release 18 related to these intelligent EM entities, highlighting the expected evolution of future wireless networks in terms of architecture, operations, and control signals.Comment: 8 pages, 5 figures, 1 table. This work has been accepted to publish in IEEE Communications Standards Magazin

Rest and Sleep Patterns and Activities of Residents in Long-term Care Facilities: A Descriptive Study

Background:To facilitate healthy occupational participation and highlight the significance of rest and sleep for older adults, this study aimed to provide a description of rest and sleep patterns and activities of residents in long-term care facilities (LTCFs). Method: Secondary analysis of rest and sleep data collected from a funded R21 study was conducted. Twenty-nine residents were interviewed using the Yesterday Interview (YI) to describe their time and daily activities, including rest and sleep patterns and activities. Results: Average time spent sleeping was 10.22 (±1.77) hr and resting was 4.77 (±3.3) hr. Data were also collected on the personal and instrumental daily living activities in which residents participated during rest time and sleep preparation. Conclusion: Occupational therapists working with residents in LTCFs are well suited to incorporate rest and sleep interventions that will enhance the occupational performance of daily living activities. Future research efforts should be directed at strategies to increase the sleep health of residents in LTCFs in collaboration with other in-house professions

Glycogen synthase kinase 3α and 3β have distinct functions during cardiogenesis of zebrafish embryo

<p>Abstract</p> <p>Background</p> <p>Glycogen synthase kinase 3 (GSK3) encodes a serine/threonine protein kinase, is known to play roles in many biological processes. Two closely related GSK3 isoforms encoded by distinct genes: GSK3α (51 kDa) and GSK3β (47 kDa). In previously studies, most GSK3 inhibitors are not only inhibiting GSK3, but are also affecting many other kinases. In addition, because of highly similarity in amino acid sequence between GSK3α and GSK3β, making it difficult to identify an inhibitor that can be selective against GSK3α or GSK3β. Thus, it is relatively difficult to address the functions of GSK3 isoforms during embryogenesis. At this study, we attempt to specifically inhibit either GSK3α or GSK3β and uncover the isoform-specific roles that GSK3 plays during cardiogenesis.</p> <p>Results</p> <p>We blocked <it>gsk3α </it>and <it>gsk3β </it>translations by injection of morpholino antisense oligonucleotides (MO). Both <it>gsk3α</it>- and <it>gsk3β</it>-MO-injected embryos displayed similar morphological defects, with a thin, string-like shaped heart and pericardial edema at 72 hours post-fertilization. However, when detailed analysis of the <it>gsk3α</it>- and <it>gsk3β</it>-MO-induced heart defects, we found that the reduced number of cardiomyocytes in <it>gsk3α </it>morphants during the heart-ring stage was due to apoptosis. On the contrary, <it>gsk3β </it>morphants did not exhibit significant apoptosis in the cardiomyocytes, and the heart developed normally during the heart-ring stage. Later, however, the heart positioning was severely disrupted in <it>gsk3β </it>morphants. <it>bmp4 </it>expression in <it>gsk3β </it>morphants was up-regulated and disrupted the asymmetry pattern in the heart. The cardiac valve defects in <it>gsk3β </it>morphants were similar to those observed in <it>axin1 </it>and <it>apc</it>^{<it>mcr </it>}mutants, suggesting that GSK3β might play a role in cardiac valve development through the Wnt/β-catenin pathway. Finally, the phenotypes of <it>gsk3α </it>mutant embryos cannot be rescued by <it>gsk3β </it>mRNA, and vice versa, demonstrating that GSK3α and GSK3β are not functionally redundant.</p> <p>Conclusion</p> <p>We conclude that (1) GSK3α, but not GSK3β, is necessary in cardiomyocyte survival; (2) the GSK3β plays important roles in modulating the left-right asymmetry and affecting heart positioning; and (3) GSK3α and GSK3β play distinct roles during zebrafish cardiogenesis.</p

Exploring Spirituality of Elders Relocating into Long-Term Care Facilities

Background: Spirituality is recognized as an important contributor to quality of life, particularly for older adults. Yet, limited research has been conducted to examine spirituality of older adults relocating to long-term care facilities (LTCFs). The intent of this mixed methods study was to cull data from a parent study to explore different aspects of spirituality among residents newly admitted to LTCFs. Method: Qualitative and quantitative data of six participants from a parent study including interviews and scores from the religious and existential well-being sections of the Spiritual Well Being Scale (SWBS) were analyzed and triangulated. Results: Descriptive analysis of the demographic data including age, gender, ethnicity, and spirituality scores was conducted. Emerging themes from the qualitative interviews included: hope/hopelessness for the future; sense of belonging in the LTCF; contentment/discontentment with life; and personal religious beliefs. These themes, in turn, were triangulated with and supported by the SWBS scores Conclusion: The findings have the potential of developing recommendations for spiritually-based interventions to facilitate successful relocation to LTCFs. Clinical implications for occupational therapy and future research are discussed

Quantitative assessment of female pattern hair loss

AbstractBackground/ObjectiveThe conventional approach to evaluate female pattern hair loss (FPHL) is to visually inspect and score images of balding area (BA). However, visual estimates vary widely among different physicians, and may hinder objective assessment of hair loss and subsequent treatment response. For this reason, we propose a quantitative method using a computer-aided imaging system to help physicians evaluate the severity of FPHL clinically.MethodsWe use a series of digital image processing techniques to measure the width of central balding area of FPHL. A total of 184 photos were collected form 33 Chinese women with FPHL (stages I-2 to II-2 on the Savin scale). Each photograph underwent standardized exposure correction. The balding areas were detected through this computer system and then transformed into an equivalent ellipse by principal component analysis. The width of ellipse [balding width (BW)] was measured. Spearman's rank correlation was used to detect the correlation between our measurements and clinical staging.ResultsExposure correction resulted in a 16.97% (|BWcorrected − BWoriginal|/BWcorrected) difference in BW.‏ The average BW was 54.98 mm in all patients, 25.79 mm in type I-2 patients, 37.41 mm in I-3, 54.08 mm in I-4, 72.10 mm in II-1, and 85.53 mm in II-2. The values of BW were correlated with Savin scale stages clinically (rBW = 0.967), which was significant statistically (p < 0.05).ConclusionA computer-aided imaging system could be a useful tool to assist physicians to evaluate the balding area more precisely for clinical staging in FPHL. The BW instead of the balding area is simple to use clinically to represent the severity of FPHL

Group A Streptococcus Subcutaneous Infection-Induced Central Nervous System Inflammation Is Attenuated by Blocking Peripheral TNF

Group A streptococcus (GAS) infection causes a strong inflammatory response associated with cytokine storms, leading to multiorgan failure, which is characterized as streptococcal toxic shock syndrome. However, little is known about GAS subcutaneous infection-mediated brain inflammation. Therefore, we used a bioluminescent GAS strain and reporter mice carrying firefly luciferase under transcriptional control of the nuclear factor-kappa B (NF-κB) promoter to concurrently monitor the host immune response and bacterial burden in a single mouse. Notably, in addition to the subcutaneous inoculation locus at the back of mice, we detected strong luminescence signals from NF-κB activation and increased inflammatory cytokine production in the brain, implying the existence of central nervous system inflammation after GAS subcutaneous infection. The inflamed brain exhibited an increased expression of glial fibrillary acidic protein and nicotinamide adenine dinucleotide phosphate oxidase components and greater microglial activation and blood–brain barrier (BBB) disruption. Furthermore, Fluoro-Jade C positive cells increased in the brain, indicating that neurons underwent degeneration. Peripheral tumor necrosis factor (TNF), which contributes to pathology in brain injury, was elevated in the circulation, and the expression of its receptor was also increased in the inflamed brain. Blockage of peripheral TNF effectively reduced brain inflammation and injury, thereby preventing BBB disruption and improving survival. Our study provides new insights into GAS-induced central nervous system inflammation, such as encephalopathy, which can be attenuated by circulating TNF blockage

Application of unsymmetrical bis-chalcone compounds in dye sensitized solar cell

A total of nine unsymmetrical bis-chalcone compounds have been synthesized and spectroscopically characterized. The unsymmetrical bis-chaclone compounds were substituted with either methoxy (OMe) or chloro (Cl) as the electron donor, and either difluoroboryl (BF2) or a ruthenium(II)-dimethylsulfoxide [Ru(II)-DMSO] complex as the electron acceptor. All these compounds were used as the dye sensitizer in dye sensitized solar cell (DSSC) by using fluorine doped tin oxide (FTO) glass coated with titanium(IV) oxide (TiO2) as the working electrode, and the indium tin oxide (ITO) glass coated with platinum as the counter electrode. The conversion efficiency of fabricated DSSCs were tested and the unsymmetrical bis-chalcone compound with OMe and BF2 substituents in the same molecule recorded the highest efficiency at 0.091%. In contrast, the unsymmetrical bis-chalcone with OMe and Ru(II)-DMSO complex has the lowest efficiency at 0.001%