Study to evaluate the efficacy of Yavani Churna and Yoga Therapy in Primary Dysmenorrhea - A Clinical Study

Dysmenorrhea or painful menstruation is a medical condition experienced by majority of adolescent girls with an estimate prevalence between 67%- 90%. Today's stressful modern lifestyle, lack of physical activity, food habits, frequent intervention of female genital tract affects the uterine environment which leads to higher incidence of Dysmenorrhea. It affects their academic performance, social activities and is a cause for school absenteeism. In Ayurveda, Dysmenorrhea is mentioned as symptom of many disorders like Vatala Yonivyapada, Paripluta Yonivyapada, Mahayoni, Udavartini Yonivyapada and Vataja Artav Dushti. Yavani (Trachyspermum ammi) is a well-known herb available in every Indian kitchen and traditionally it was used for curing numerous ailments. Ayurveda mentioned its properties as Vatanuloman, Shothahara, Shoolaghgna etc. Yoga is a non-pharmacological treatment modality popularly useful in several diseases. Several researches also proved the positive effect of Yavani and Yoga on pain inflammation, oxidative stress etc. Thus, for present study Yavani Churna and Yoga therapy has selected and clinical trial was conducted on 40 patients of Primary Dysmenorrhea for two consecutive cycle (2 month). These patients were divided into 2 groups as group A (Yavani Churna and Yoga Therapy) and group B (Yavani Churna). After 2 consecutive cycles, results showed significant improvement in pain as well as other clinical parameters

CONTROLLED ELECTRON LEAKAGE IN ELECTRON BLOCKING LAYER FREE InGaN/GaN NANOWIRE LIGHT-EMITTING DIODES

In this study, we have proposed and investigated the effect of coupled quantum wells to reduce electron overflow in InGaN/GaN nanowire white color light-emitting diodes. The coupled quantum well before the active region could decrease the thermal velocity, which leads to a reduced electron mean free path. This improves the electron confinement in the active region and mitigates electron overflow in the devices. In addition, coupled quantum well after the active region utilizes the leaked electrons from the active region and contributes to the white light emission. Therefore, the output power and external quantum efficiency of the proposed nanowire LEDs are improved. Moreover, the efficiency droop was negligible up to 900 mA injection current

Spin Vortex Resonance in Non-planar Ferromagnetic Dots

In planar structures, the vortex resonance frequency changes little as a function of an in-plane magnetic field as long as the vortex state persists. Altering the topography of the element leads to a vastly different dynamic response that arises due to the local vortex core confinement effect. In this work, we studied the magnetic excitations in non-planar ferromagnetic dots using a broadband microwave spectroscopy technique. Two distinct resonance frequency ranges were observed depending on the position of the vortex core controllable by applying a relatively small magnetic field. The micromagnetic simulations are in qualitative agreement with the. experimental results

Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages

Background: Pancreatic ductal adenocarcinoma (PDAC) is a highly desmoplastic tumor with a dismal prognosis for most patients. Fibrosis and inflammation are hallmarks of tumor desmoplasia. We have previously demonstrated that preventing the activation of pancreatic stellate cells (PSCs) and alleviating desmoplasia are beneficial strategies in treating PDAC. Metformin is a widely used glucose-lowering drug. It is also frequently prescribed to diabetic pancreatic cancer patients and has been shown to associate with a better outcome. However, the underlying mechanisms of this benefit remain unclear. Metformin has been found to modulate the activity of stellate cells in other disease settings. In this study, we examine the effect of metformin on PSC activity, fibrosis and inflammation in PDACs. Methods/Results In overweight, diabetic PDAC patients and pre-clinical mouse models, treatment with metformin reduced levels of tumor extracellular matrix (ECM) components, in particular hyaluronan (HA). In vitro, we found that metformin reduced TGF-ß signaling and the production of HA and collagen-I in cultured PSCs. Furthermore, we found that metformin alleviates tumor inflammation by reducing the expression of inflammatory cytokines including IL-1β as well as infiltration and M2 polarization of tumor-associated macrophages (TAMs) in vitro and in vivo. These effects on macrophages in vitro appear to be associated with a modulation of the AMPK/STAT3 pathway by metformin. Finally, we found in our preclinical models that the alleviation of desmoplasia by metformin was associated with a reduction in ECM remodeling, epithelial-to-mesenchymal transition (EMT) and ultimately systemic metastasis. Conclusion: Metformin alleviates the fibro-inflammatory microenvironment in obese/diabetic individuals with pancreatic cancer by reprogramming PSCs and TAMs, which correlates with reduced disease progression. Metformin should be tested/explored as part of the treatment strategy in overweight diabetic PDAC patients

Impact of Junk food on Physical and Mental health of the Youngsters in Bhopal city - A Cross Sectional Survey Study

Background- Ayurveda has given a unique concept of Viruddha Ahara. Junk food an energy-dense food could be consider as Viruddha Ahara because of its serious physical and mental health consequences. Aim - Find out the frequency of consumption of Junk food preparation and their effects on Physical & Mental health in the youngsters of Bhopal city with special reference to Viruddha Ahara. Study Design- was Observational cross sectional study. Material and Method- Modified Questionnaire based on WHO STEPS1, 2 and 3 guidelines was used to collect the data. 600 youngsters of age group between 12-25 years from various schools and colleges of Bhopal city were selected by stratified random sampling technique and Statistical Analysis was done with epi infoTM version 7 software. Appropriate statistical tests were applied such as frequency distribution, cross tabulation (M x N/ 2 x 2 Table), chi square test, z statistics and logistic regression analysis. Odds ratios (OR) with 95% confidence intervals (C.I) and p-value (significant <0.05) were also calculated as per need. Result- It was observed that all subjects were consuming different kinds of junk food with high mean frequency that was 3.28 days per week.  Maximum youngsters were suffering from various physical and mental health consequences like 80.83% subjects were suffering from nutritional problem, 73.50% skin problems, 73.33 % GIT problems and 58.67% had anxiety disorder and 38.50% had recognised with mood disorder. Conclusion: The result of the survey study indicating that serious health consequences are developing in youngsters by consumption of viruddha ahara (Junk Food) and that could be converted them in chronic disease patients in near future

Critical review on Haritaki w.s.r. to Sthaulya (obesity)

Obesity is a major risk factor for a number of chronic diseases, including Diabetes, Cardiovascular disease & Cancer etc. In 2013, the American Medical Association (AMA) declared Obesity a disease that requires a range of interventions to advance treatment & prevention.  So, it is the need of the hour to develop better treatment protocol to treat & prevent the condition. Ayurveda has the potential in the prevention, management & improvement of the quality of life in obese patient. Haritaki having properties like Kaphaghna, Medoghna, Deepana, Pachana, Ruksha, Laghu Guna, Katu, Tikta Rasa and Ushna Veerya, it does the Sthaulya Samprapti Vighatana. Various studies also suggested that Haritaki possesses an antiobesity and hypolipidemic effects based on Kaphanashak and Medoghna properties and presence of its biologically active components like saponins, phytosterols, chebulinic acid and corilagin. Therefore, Haritaki can be useful as an adjuvant therapy for Obesity

Assessment of the Effect of Raga Therapy & Nisha Amalaki Churna on Prehypertension - A clinical study

Background: Prehypertension is classified as elevated blood pressure above normal by American medical classification. JNC 7 suggested systolic between 120 to 139 mmHg or diastolic 80 to 89 mmHg should be consider as Pre-hypertension. Oxidative stress develops due to stress and anxiety is recognized as main risk factor for initiation of hypertension. The Nada Yoga (sound based yoga) practices has been reported to decreases stress and anxiety. Nisha Amalaki Churna the combination of Amalaki (Indian gooseberry) and Haridra (turmeric) powder also reported to effectively reduces oxidative stress. Aim - To assess the combined effect of Indian Classical Raga Ahirbhairav and Hindol along with Nisha Amalaki Churna on Prehypertension. Material and method- It was clinical study. Total 48 patients selected by purposive sample technique and then divided into 2 groups (n = 24 each) randomly. Assessment was done by criteria of pre hypertension given by JNC 7. Result - In present study group A (Raga Ahirbhairav, Raga Hindol and Nisha Amalki Churna) patients the mean score of Systolic B.P. had decreased from 135.50 to 120.76 (Mean difference 14.74) with extremely significance (p <0.0001) compare to group B (only Nisha Amalki Churna orally) and mean score of Diastolic B.P. had decreased from 88.61 to 79.706 (Mean difference 8.904) with extremely significant (p <0.0001) compare to group B. Relief in mild headache 31.94% (p<0.01), relief in Anxiety 52.67% (p<0.0001) and relief on stress was reported 34.56% (p<0.0001) in Group A were reported, compare to Group B. Conclusion- result of study indicating that Raga therapy with Nisha Amalaki Churna had potential in the management of pre hypertension

Gnathostomiasis: A rare case of cutaneous creeping eruptions

A 21-year-old vegetarian lady presenting with migratory erythema and pain in her right hand subsequently developed a blister on the palm. A worm-like structure came out of the wound and was identified as Gnathostoma spp. adult male worm. It is a very rare cause of creeping eruptions and so far only one case of cutaneous gnathostomiasis caused by a larva has been reported from India. This is the first case of cutaneous gnathostomiasis due to an adult Gnathostoma spp. in India