Three-Qubit Gate Realization Using Single Quantum Particle

Using virtual spin formalism it is shown that a quantum particle with eight energy levels can store three qubits. The formalism allows to realize a universal set of quantum gates. Feasible formalism implementation is suggested which uses nuclear spin-7/2 as a storage medium and radio frequency pulses as the gates. One pulse realization of all universal gates has been found, including three-qubit Toffoli gate.Comment: LaTeX, 6 pages, no figures; Submitted to "Pis'ma v Zh. Eksp. Teor. Fiz.

Quantum lattice gases and their invariants

The one particle sector of the simplest one dimensional quantum lattice gas automaton has been observed to simulate both the (relativistic) Dirac and (nonrelativistic) Schroedinger equations, in different continuum limits. By analyzing the discrete analogues of plane waves in this sector we find conserved quantities corresponding to energy and momentum. We show that the Klein paradox obtains so that in some regimes the model must be considered to be relativistic and the negative energy modes interpreted as positive energy modes of antiparticles. With a formally similar approach--the Bethe ansatz--we find the evolution eigenfunctions in the two particle sector of the quantum lattice gas automaton and conclude by discussing consequences of these calculations and their extension to more particles, additional velocities, and higher dimensions.Comment: 19 pages, plain TeX, 11 PostScript figures included with epsf.tex (ignore the under/overfull \vbox error messages

Directional Soliton and Breather Beams

Solitons and breathers are nonlinear modes that exist in a wide range of physical systems. They are fundamental solutions of a number of nonlinear wave evolution equations, including the uni-directional nonlinear Schr\"odinger equation (NLSE). We report the observation of slanted solitons and breathers propagating at an angle with respect to the direction of propagation of the wave field. As the coherence is diagonal, the scale in the crest direction becomes finite, consequently, a beam dynamics forms. Spatio-temporal measurements of the water surface elevation are obtained by stereo-reconstructing the positions of the floating markers placed on a regular lattice and recorded with two synchronized high-speed cameras. Experimental results, based on the predictions obtained from the (2D+1) hyperbolic NLSE equation, are in excellent agreement with the theory. Our study proves the existence of such unique and coherent wave packets and has serious implications for practical applications in optical sciences and physical oceanography. Moreover, unstable wave fields in this geometry may explain the formation of directional large amplitude rogue waves with a finite crest length within a wide range of nonlinear dispersive media, such as Bose-Einstein condensates, plasma, hydrodynamics and optics

Field ultrasound evaluation of some gestational parameters in jennies

The aim of this study was to collect and analyze ultrasound measurements of fetal-maternal structures during normal and pathological pregnancies in jennies, a livestock species of growing interest. For two breeding seasons, 38 jennies of different breeds and crossbreeds aged between 3 and 18 years were monitored weekly by transrectal examination using a portable Esaote ultrasound (MyLab\u2122 30 GOLD VET) with a 5\u20137.5 MHz probe. The jennies were divided into two groups, < 250 kg and >250 kg body weight, and the dates of conception and parturition/abortion were recorded to calculate pregnancy length. Descriptive statistics were performed for the following variables: pregnancy length and maternal-fetal parameters (measurements of the orbit, gastric bubble, thorax, abdomen, gonads, heart rate, umbilical artery velocimetry, and combined utero-placental thickness). A total of 68 pregnancies were studied, 36 of which ended during the study period. The average pregnancy length was 370.82 \ub1 16.6 days for full-term pregnancies (N = 28, 77.8%) and 316.13 \ub1 36.6 days for abortions (N = 8, 22.2%). The season of conception and fetal gender did not affect the pregnancy length. Pregnancy examination can reasonably be performed by two weeks after last service if ovulation date is not known. The orbital diameter was the most reliable parameter for monitoring the physiological development of the embryo and fetus, and it was strongly related to the gestational age. No differences in fetal development were observed in relation to the mother's body weight. The combined utero-placental thickness was not associated with the gestational age and thickening and edema, frequently observed, were not associated with fetal pathologies

Evading quantum mechanics

Quantum mechanics is potentially advantageous for certain information-processing tasks, but its probabilistic nature and requirement of measurement back action often limit the precision of conventional classical information-processing devices, such as sensors and atomic clocks. Here we show that by engineering the dynamics of coupled quantum systems, it is possible to construct a subsystem that evades the measurement back action of quantum mechanics, at all times of interest, and obeys any classical dynamics, linear or nonlinear, that we choose. We call such a system a quantum-mechanics-free subsystem (QMFS). All of the observables of a QMFS are quantum-nondemolition (QND) observables; moreover, they are dynamical QND observables, thus demolishing the widely held belief that QND observables are constants of motion. QMFSs point to a new strategy for designing classical information-processing devices in regimes where quantum noise is detrimental, unifying previous approaches that employ QND observables, back-action evasion, and quantum noise cancellation. Potential applications include gravitational-wave detection, optomechanical force sensing, atomic magnetometry, and classical computing. Demonstrations of dynamical QMFSs include the generation of broad-band squeezed light for use in interferometric gravitational-wave detection, experiments using entangled atomic spin ensembles, and implementations of the quantum Toffoli gate.Comment: v2: changed the title, added a figure, and made some minor update

TRAIL treatment prevents renal morphological changes and TGF-\u3b2-induced mesenchymal transition associated with diabetic nephropathy

BACKGROUND: TNF-related apoptosis-inducing ligand (TRAIL) has attracted attention not only as an anti-cancer agent, but also as a potential treatment for diabetes. Animal studies have shown that TRAIL delivery ameliorated glucose control in type 1 and type 2 diabetes. It is currently unknown whether TRAIL positive effects are maintained in more severe forms of type 2 diabetes, and whether they include renoprotection. Our study aimed at evaluating TRAIL effects in a severe form of type 2 diabetes with nephropathy. MATERIALS AND METHODS: A total of 20 db/db mice were treated with saline or TRAIL twice per week for 12 weeks. In parallel, renal tubular epithelial cells were cultured with TGF-\u3b21 in the presence and absence of TRAIL, with and without silencing TRAIL-specific receptor (DR5) and leptin receptor. RESULTS: TRAIL did not improve glucose control, but it significantly reduced circulating interleukin (IL)-6 and resistin. In the kidney, TRAIL treatment significantly ameliorated glomerular and tubular morphology with an improvement in kidney function, but no effect on proteinuria. Our in vitro studies on TGF-\u3b21-treated cells, showed that by binding to DR5, TRAIL rescued normal tubular cell morphology, increasing E-cadherin and reducing \u3b1-smooth muscle actin (SMA) expression, with no effects on cell viability. Interestingly, both in vivo and in vitro, TRAIL reduced the accumulation of the autophagy substrate p62. CONCLUSIONS: Our data confirm TRAIL protective effects against organ damage and shed light on to promising anti-fibrotic actions, which are independent of glucose control. TRAIL anti-fibrotic actions might be due to the rescue of autophagy in diabetes

ELISA assay employing epitope-specific monoclonal antibodies to quantify circulating HER2 with potential application in monitoring cancer patients undergoing therapy with trastuzumab

Circulating HER2 extracellular domain (HER2 ECD) levels were proposed as a surrogate for HER2 tissue expression to monitor breast cancer patients for early relapse or responses to standard or HER2-targeted therapies, such as the monoclonal antibody (mAb) trastuzumab. Currently, available commercial ELISA assays for HER2 ECD rely on antibodies recognizing undisclosed or unknown epitopes. In this work, two ELISA assays employing MGR2 and MGR3 epitope-specific mAbs for HER2 ECD were developed and validated, showing good assay precision and linearity of the dose-response signal within the dynamic range of 0.19–12.50 ng mL−1 and detection limits of 0.76 and 0.75 ng mL−1 for the MGR2 and MGR3 assays, respectively. The developed assay showed a good agreement with two widely used commercial kits for HER2 ECD quantification in serum samples from breast cancer patients. A complete characterization of mAb-HER2 ECD interaction was performed by means of surface plasmon resonance using trastuzumab as control for both epitope mapping and kinetics analysis. The epitopes recognized by the two mAbs showed no overlap with trastuzumab, which was confirmed by trastuzumab interference analysis in serum samples. The method showed to be a practical approach to determine HER2 ECD with a high degree of sensitivity, reliability and recovery in samples containing mAbs-based therapies

Rogue Waves: From Nonlinear Schrödinger Breather Solutions to Sea-Keeping Test

Under suitable assumptions, the nonlinear dynamics of surface gravity waves can be modeled by the one-dimensional nonlinear Schrödinger equation. Besides traveling wave solutions like solitons, this model admits also breather solutions that are now considered as prototypes of rogue waves in ocean. We propose a novel technique to study the interaction between waves and ships/structures during extreme ocean conditions using such breather solutions. In particular, we discuss a state of the art sea-keeping test in a 90-meter long wave tank by creating a Peregrine breather solution hitting a scaled chemical tanker and we discuss its potential devastating effects on the ship

Probing Intermolecular H-Bonding Interactions in Cyanuric Acid Networks: Quenching of the N K-Edge Sigma Resonances

The electronic characterization of the cyanuric acid both in gas phase and when embedded within an H-bonded scheme forming a monolayer on the Au(111) surface has been performed by means of X-ray Photoelectron Spectroscopy (XPS) and Near Edge X-ray Absorption Fine Structure (NEXAFS) spectroscopy. The experimental spectra at the N, O, and C K-edges have been assigned with the support of DFT calculations, and the combination between theory and experiment has allowed to us investigate the effect of the H-bonding intermolecular interaction on the spectra. In particular, the H-bond formation in the monolayer leads to a quenching of the N 1s NEXAFS resonances associated with transitions to the sigma empty orbitals localized on the N-H portion of the imide group. On the other hand, the pi* empty states remain substantially unperturbed. From a computational point of view, it has been shown that the DFT-TP scheme is not able to describe the N 1s NEXAFS spectra of these systems, and the configuration mixing has to be included, through the TDDFT approach in conjunction with the range-separated XC CAM-B3LYP functional, to obtain a correct reproduction of the N 1s core spectra

Inverse Geometric Approach to the Simulation of the Circular Growth. The Case of Multicellular Tumor Spheroids

We demonstrate the power of the genetic algorithms to construct the cellular automata model simulating the growth of 2-dimensional close-to-circular clusters revealing the desired properties, such as the growth rate and, at the same time, the fractal behavior of their contours. The possible application of the approach in the field of tumor modeling is outlined