15 research outputs found

    Scatterplot showing the correlation between response speed and lateralized initial motor potential peak amplitude (iMP’) for children with ADHD and healthy control children ([C3−C4]/2).

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    <p>Scatterplot showing the correlation between response speed and lateralized initial motor potential peak amplitude (iMP’) for children with ADHD and healthy control children ([C3−C4]/2).</p

    Time-course and topography of response-locked movement-related potentials (initial movement related potential peak - iMP) including the topography of iMP lateralization ([C3−C4]/2).

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    <p>For control children, averages of all responses are illustrated together with a separate presentation of averages of fast (below median reaction time) and slow responses (above median reaction time). For children with ADHD, responses on and off methylphenidate are presented. For effects of response speed in ADHD see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0039012#pone-0039012-g004" target="_blank">Figure 4</a>. Note how the rather symmetrically distributed stimulus-related P300 shadowed MRP in the topography before the subtraction of symmetrically distributed potential components by the calculation of lateralization. iMP time-course (thick black arrows) and lateralized topography around C3 (grey arrows) are in good agreement with previous literature. mPINV (lateralized negativity at C3 in the time interval 500–800 ms) was not shadowed by P300 any more. Its topography is presented in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0039012#pone-0039012-g002" target="_blank">Figure 2</a>.</p

    Motor PINV topography for healthy control children.

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    <p>(top; from left to right: all responses, fast responses below median reaction time, slow responses above median reaction time) <b>and children with ADHD</b> (bottom; from left to right: responses off and on methylphenidate) for the motor PINV time interval (500–800 ms after the response trigger, motor post-processing).</p

    Group effects and effects of stimulant medication.

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    <p>Grand average of lateralized motor potentials ([C3<b>−</b>C4]/2) for children with ADHD and healthy control children. In ADHD children, the potential waveform before and after intake of 10 mg methylphenidate are shown – the order in which the sessions were recorded was counterbalanced.</p

    Association of <i>DCKL1</i> genetic variants with psychiatric and cognitive traits.

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    <p>Markers are ordered from 5′ to 3′ of the gene, anti-sense to the reference sequence. <b>A.</b> Representation of the genomic region covered and of 6 <i>DCLK1</i> transcripts (from top to bottom: <i>DCL</i>, <i>CARP</i>, 2 short variants and 2 long variants). In addition to alternative start sites, the transcripts can be alternatively spliced for part of exon 9, for exon 19 and in the 3′UTR. <b>B.</b> All markers showing nominal association to psychiatric traits in this study or to cognitive traits in our previous study <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035424#pone.0035424-LeHellard1" target="_blank">[16]</a> are displayed. Color code: yellow, P-value between 0.05 and 0.001; orange, P-value between 0.001 and 0.0001; red, P-value<0.0001; white, P-value>0.05; grey, marker not tested in this sample. The markers used in the cross-phenotype analyses are highlighted in red. <b>C.</b> LD between the markers used in the cross-phenotype analyses, and the markers associated with cognitive traits in our previous study <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0035424#pone.0035424-LeHellard1" target="_blank">[16]</a>. LD is displayed using a r<sup>2</sup> scale ranging from r<sup>2</sup> = 1 in black to r<sup>2</sup> = 0 in white.</p
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