SOLUBILITY ENHANCEMENT OF NORFLOXACIN BY HYDROTROPY TECHNIQUE

The objective of this study is to improve the solubility of poorly water soluble anti-bacterial drug Norfloxacin by hydrotropic solubilization technique. For the present study sodium benzoate was used as hydrotropic agent. By using this hydrotropic agent as water soluble carrier, hydrotropic solid dispersions of Norfloxacin were prepared.in 1:1, 1:2, 1:3 and 1:4 ratios (drug: hydrotropic agent). Equilibrium solubilization of pure drug and hydrotropic solid dispersions of Norfloxacin in distilled water by excess solute method and solubility enhancement ratios were calculated by measuring the absorbance of the solutions at 274.80 nm using UV spectrophotometer. The hydrotropic agent did not interfere in analysis. The results showed that there was an increase in the solubility of Norfloxacin with hydrotropic solid dispersions compared to pure drug in distilled water. There was 9.56 fold enhancement in aqueous solubility of Norfloxacin with hydrotropic solid dispersion of 1:4 ratio compared to 1:1 (6.29), 1:2 (7.09) and 1:3 (8.59) ratios

Comparative study of transdermal drug delivery systems of resveratrol: High efficiency of deformable liposomes

Trans-resveratrol (3, 5, 4′ trihydroxystilbene, RSV) is a natural compound that shows antioxidant, cardioprotective, anti-inflammatory and anticancer properties. The transdermal, painless application of RSV is an attractive option to other administration routes owing to its several advantages like avoiding gastrointestinalproblems and first pass metabolism. However, its therapeutic potential is limited by its low solubility and lowstability in water and the reduced permeability of stratum corneum. To overcome these inconveniences theencapsulation of this compound in a drug delivery system is proposed here. In order to find the best carrier fortransdermal application of RSV various liposomal nanoparticulate carriers like conventional liposomes (L-RSV),deformable liposomes (LD-RSV), ultradeformable liposomes (LUD-RSV) and ethosomes (Etho-RSV) were assayed. Transmission electron microscopic (TEM) and dynamic light scattering (DLS) studies were performed toanalyze the surface morphology of these carriers. Structural characterization for these formulations was performed by confocal Raman spectroscopy. The spectroscopic results were analysed in conjunction with calorimetric data to identify the conformational changes and stability of formulations in the different nanoparticlesinduced by the presence of RSV.Comparison of the results obtained with the different carrier systems (L-RSV, LD-RSV, LUD-RSV and EthoRSV) revealed that the best RSV carrier was LD-RSV. The increase in the fluidity of the bilayers in the region ofthe hydrophobic chains of the phospholipid by ethanol probably facilitates the accommodation of the RSV in thebilayer and contributes to the improved encapsulation of RSV without affecting the mobility of this carrier.Fil: Gaspar Tosato, Maira. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Maya Giron, Julie Viviana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Abrahao Martin, Airton. Universidade Federal Do Piauí; BrasilFil: Krishna Tippavajhala, Vamshi. Manipal University; IndiaFil: Fernandez Lorenzo, Monica Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Dicelio, Lelia Elina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química, Física de los Materiales, Medioambiente y Energía. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química, Física de los Materiales, Medioambiente y Energía; Argentin

Comparative study of transdermal drug delivery systems of resveratrol: high efficiency of deformable liposomes

Trans-resveratrol (3, 5, 4′ trihydroxystilbene, RSV) is a natural compound that shows antioxidant, cardioprotective, anti-inflammatory and anticancer properties. The transdermal, painless application of RSV is an attractive option to other administration routes owing to its several advantages like avoiding gastrointestinal problems and first pass metabolism. However, its therapeutic potential is limited by its low solubility and low stability in water and the reduced permeability of stratum corneum. To overcome these inconveniences the encapsulation of this compound in a drug delivery system is proposed here. In order to find the best carrier for transdermal application of RSV various liposomal nanoparticulate carriers like conventional liposomes (L-RSV), deformable liposomes (LD-RSV), ultradeformable liposomes (LUD-RSV) and ethosomes (Etho-RSV) were assayed. Transmission electron microscopic (TEM) and dynamic light scattering (DLS) studies were performed to analyze the surface morphology of these carriers. Structural characterization for these formulations was performed by confocal Raman spectroscopy. The spectroscopic results were analysed in conjunction with calorimetric data to identify the conformational changes and stability of formulations in the different nanoparticles induced by the presence of RSV. Comparison of the results obtained with the different carrier systems (L-RSV, LD-RSV, LUD-RSV and Etho-RSV) revealed that the best RSV carrier was LD-RSV. The increase in the fluidity of the bilayers in the region of the hydrophobic chains of the phospholipid by ethanol probably facilitates the accommodation of the RSV in the bilayer and contributes to the improved encapsulation of RSV without affecting the mobility of this carrier.Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicada