Results for question: ‘Would you give your permission for your DNA to be used in…’.

<p>Figures are in percentages.</p><p>Results for question: ‘Would you give your permission for your DNA to be used in…’.</p

Results for question: ‘Would you give your permission for your MEDICAL INFORMATION AND DNA from the “study of Disease A” to be used in the UK for ….’.

<p>Figures are in percentages.</p><p>Results for question: ‘Would you give your permission for your MEDICAL INFORMATION AND DNA from the “study of Disease A” to be used in the UK for ….’.</p

Results for question: ‘Would you give permission for your MEDICAL INFORMATION to be used in…’

<p>Figures are in percentages.</p><p>Results for question: ‘Would you give permission for your MEDICAL INFORMATION to be used in…’</p

Results for questions: ‘If you were in an NHS hospital receiving treatment for an illness, would you be happy to be AUTOMATICALLY enrolled ….’

<p>Figures are percentages.</p><p>Results for questions: ‘If you were in an NHS hospital receiving treatment for an illness, would you be happy to be AUTOMATICALLY enrolled ….’</p

NAHR deletion rate at the <i>CMT1A</i> locus in all the sperm samples analysed with men grouped according to <i>PRDM9</i> zinc finger motif-binding status.

<p>Men homozygous for alleles recognising the canonical motif (shown in red) or heterozygous for alleles recognising the canonical and non-canonical motifs (shown in blue) are grouped separately and shown in ascending order. The 95% confidence intervals for each estimate of deletion rate are shown.</p

NAHR deletion rate at the <i>CMT1A</i> locus in MZ co-twins.

<p>The estimates of deletion rate for each co-twin are plotted against one another, with 95% confidence intervals for each estimate also shown.</p

NAHR deletion rate at the <i>CMT1A</i> locus plotted against age at the time the sample was provided.

<p>In cases where multiple individuals have the same age the points are plotted slightly offset from each other on the x-axis. The 95% confidence intervals for each estimate of deletion rate are shown.</p

Characteristics of study participants from three cohorts.

<p>*Including the subtelomeric segment.</p

SNPs associated with MCHC in the INGI-VB cohort.

<p>SNPs associated with MCHC in the INGI-VB cohort.</p

Sequence variants identified in the <i>TERC</i> gene.

<p>Sequence variants identified in the <i>TERC</i> gene.</p