Supplemental_Table_3_by_hearing_level_20191029 - Within-Subject Analysis of Auditory Brain Stem Responses in Adults With Unilateral Tinnitus

Supplemental_Table_3_by_hearing_level_20191029 for Within-Subject Analysis of Auditory Brain Stem Responses in Adults With Unilateral Tinnitus by Pey-Yu Chen and Tien-Chen Liu in Ear, Nose & Throat Journal</p

Supplemental_Table_2_by_configuration_20191029 - Within-Subject Analysis of Auditory Brain Stem Responses in Adults With Unilateral Tinnitus

Supplemental_Table_2_by_configuration_20191029 for Within-Subject Analysis of Auditory Brain Stem Responses in Adults With Unilateral Tinnitus by Pey-Yu Chen and Tien-Chen Liu in Ear, Nose & Throat Journal</p

Supplemental_Table_1_20191028 - Within-Subject Analysis of Auditory Brain Stem Responses in Adults With Unilateral Tinnitus

Supplemental_Table_1_20191028 for Within-Subject Analysis of Auditory Brain Stem Responses in Adults With Unilateral Tinnitus by Pey-Yu Chen and Tien-Chen Liu in Ear, Nose & Throat Journal</p

Percentages of correct MMRT responses among the 15 subjects at a moderate speech level.

<p>Data show mean and standard deviation values.</p

Observations of cochlear sections by H&E stain in both groups at the end of this study.

<p>Abbreviations: SD: standard deviation; DIO: diet-induced obesity; SV: stria vascularis; SG: spiral ganglion; SL: spiral ligament; IHC: inner hair cell; OHCs: outer hair cells.</p><p>N = 30 for all observations except for the apical turn (n = 14).</p><p>*Student's t-test for SV thickness, internal diameter of vessels in SV, and vessel wall to radius ratio in SV. Wilcoxon rank-sum test for other items.</p

Development and Preliminary Verification of a Mandarin-Based Hearing-Aid Fitting Strategy

<div><p>Objective</p><p>The purpose of this study was to design and to verify a new hearing-aid fitting strategy (Aescu HRL-1) based on the acoustic features of Mandarin. The subjective and objective outcomes were compared to those fitted with NAL-NL1 (National Acoustic Laboratory Non-Linear, version1) in Mandarin-speaking hearing-aid users. </p> <p>Design</p><p>Fifteen subjects with sensorineural hearing loss participated in this preliminary study. Each subject wore a pair of four-channel hearing aids fitted with the Aescu HRL-1 and NAL-NL1 prescriptions alternatively for 1 month. Objective and subjective tests including the Mandarin Monosyllable Recognition Test (MMRT), Mandarin Hearing in Noise Test (MHINT), International Outcome Inventory for Hearing Aids (IOI-HA), and a sound-quality questionnaire were used to evaluate the performance of the two prescriptions. </p> <p>Results</p><p>The mean MMRT scores were 79.9% and 81.1% for NAL-NL1 and Aescu HRL-1 respectively. They are not statistically different. The corresponding MHINT signal-to-noise ratios were 0.87 and 0.85 dB, also, no significant difference was found between these two strategies. However, in subjective questionnaires, overall, the sound-quality and IOI-HA scores were higher for Aescu HRL-1. </p> <p>Conclusions</p><p>The speech recognition performance based on Aescu HRL-1 is as good as that of NAL-NL1 for Mandarin-speaking hearing-aid users. Moreover, the subjects generally responded that Aescu HRL-1 provides a more natural, richer, and better sound quality than does NAL-NL1.</p> </div

Example loudness-growth curves for Aescu HRL-1.

<p>(a). Original loudness-growth curve of a hearing-impaired individual. (b). Loudness-growth curve of a hearing-impaired individual based on the Mandarin speechmap. </p

Example fitting results for the NAL-NL1 (left) and Aescu HRL-1 (right) prescriptions at a moderate speech level.

<p>The top, bottom, and middle curves of the green region represent L99, L30, and the LTASS in the speech map, respectively. The red curve is the hearing threshold and the white star symbols indicate the predicted discomfort levels. </p

Signal-to-noise ratio required for a 50% correct rate in the MHINT in noise for the 15 subjects at a moderate speech level.

<p>Data show mean and standard deviation values.</p

Immunohistochemical studies of cochlea.

<p>Representative radial section of hypoxia-induced factor (HIF) 1-α staining in the cochlear basal turn (a,b). The intensity of HIF-1α stain was significantly greater in the DIO group than in the control group in the SG and SL (c). Representative radial section of TNF-α stain in the cochlear basal turn (d,e). The intensity of tumor necrosis factor (TNF)-α stain was significantly tenser in the DIO group than in the control group in SG and SL (f). Representative radial section of NF-κB stain in the cochlear basal turn (g,h). The intensity of nuclear factor kappaB (NF-κB) stain was significantly greater in the DIO group than in the control group in SG and SL (i).</p