23 research outputs found
Contrast image and RGB three-channel histogram.
(a) Original; (b) Contrast enhancement; (c) Original histogram; (d) Histogram after contrast enhancement.</p
Color correction test.
(a) Degraded color card; (b) Standard card; (c) UDCP; (d) DRDCP; (e) Fusion; (f) UNTV; (g) MLFcGAN; (h) FUnIE-GAN; (i) UWCNN; (j) Water-Net; (k) Ours.</p
Data File 1.csv
Statistical results of radii and lattice constants in both x and y directions. SEM images are obtained throughout the sample area uniformly, and 64 disks are captured (4 disks per image)
Table_1_A hybrid sensory feedback system for thermal nociceptive warning and protection in prosthetic hand.docx
BackgroundAdvanced prosthetic hands may embed nanosensors and microelectronics in their cosmetic skin. Heat influx may cause damage to these delicate structures. Protecting the integrity of the prosthetic hand becomes critical and necessary to ensure sustainable function. This study aims to mimic the sensorimotor control strategy of the human hand in perceiving nociceptive stimuli and triggering self-protective mechanisms and to investigate how similar neuromorphic mechanisms implemented in prosthetic hand can allow amputees to both volitionally release a hot object upon a nociceptive warning and achieve reinforced release via a bionic withdrawal reflex.MethodsA steady-state temperature prediction algorithm was proposed to shorten the long response time of a thermosensitive temperature sensor. A hybrid sensory strategy for transmitting force and a nociceptive temperature warning using transcutaneous electrical nerve stimulation based on evoked tactile sensations was designed to reconstruct the nociceptive sensory loop for amputees. A bionic withdrawal reflex using neuromorphic muscle control technology was used so that the prosthetic hand reflexively opened when a harmful temperature was detected. Four able-bodied subjects and two forearm amputees randomly grasped a tube at the different temperatures based on these strategies.ResultsThe average prediction error of temperature prediction algorithm was 8.30 ± 6.00%. The average success rate of six subjects in perceiving force and nociceptive temperature warnings was 86.90 and 94.30%, respectively. Under the reinforcement control mode in Test 2, the median reaction time of all subjects was 1.39 s, which was significantly faster than the median reaction time of 1.93 s in Test 1, in which two able-bodied subjects and two amputees participated. Results demonstrated the effectiveness of the integration of nociceptive sensory strategy and withdrawal reflex control strategy in a closed loop and also showed that amputees restored the warning of nociceptive sensation while also being able to withdraw from thermal danger through both voluntary and reflexive protection.ConclusionThis study demonstrated that it is feasible to restore the sensorimotor ability of amputees to warn and react against thermal nociceptive stimuli. Results further showed that the voluntary release and withdrawal reflex can work together to reinforce heat protection. Nevertheless, fusing voluntary and reflex functions for prosthetic performance in activities of daily living awaits a more cogent strategy in sensorimotor control.</p
Hierarchical Structure Formation and Effect Mechanism of Ni/Mn Layered Double Hydroxides Microspheres with Large-Scale Production for Flexible Asymmetric Supercapacitors
In
this study, Ni/Mn layered double hydroxides (LDHs) microspheres with
three-dimensional flower-like hierarchical structure are fabricated
by a large-scale and self-assembled chemical coprecipitation strategy
(at 55 °C under normal pressure). In each integrated microsphere,
the petals consist of ultrathin two-dimensional nanosheets. The self-assembly
formation mechanism of this flower-like construction is systematically
investigated according to the analysis results from the regulation
of various reaction factors. The Ni/Mn LDHs microspheres show an optimal
capacitance value as high as 1379 F·g<sup>–1</sup> at
1 A·g<sup>–1</sup>. Sum frequency generation spectroscopy
and charge storage behavior mechanism analysis further demonstrate
that a favorable capacitive constitution is indeed dependent on the
synergistic effect of active sites (different feed ratios) and surface
area (different architectural features). Moreover, a novel flexible
all-solid-state asymmetric supercapacitor is assembled by exploiting
these microspheres and active carbon as positive and negative electrode
materials respectively, which exhibits a superior capacitance value
of 393 F·g<sup>–1</sup> (1 A·g<sup>–1</sup>) and energy and power density of 131.17 Wh·kg<sup>–1</sup> and 1.45 KW·kg<sup>–1</sup> with favorable cyclic life
(remains over 75.1% after 5000 cycles under 50 mV·s<sup>–1</sup>), respectively. Overall, this work provides a significant prospect
and deep understanding for the development of the next generation
of flexible energy devices
Additional file 2 of ILC1-derived IFN-γ regulates macrophage activation in colon cancer
Additional file 2. Anti-IFN-g down-regulates M1 macrophage while increase M2 Macrophage percentage
Additional file 1 of ILC1-derived IFN-γ regulates macrophage activation in colon cancer
Additional file 1. Gating strategies
Additional file 3 of ILC1-derived IFN-γ regulates macrophage activation in colon cancer
Additional file 3. WB raw data
Additional file 4 of ILC1-derived IFN-γ regulates macrophage activation in colon cancer
Additional file 4. WB raw data
Table_5_Uncovering lupus nephritis-specific genes and the potential of TNFRSF17-targeted immunotherapy: a high-throughput sequencing study.xlsx
IntroductionLupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE). This study aimed to identify LN specific-genes and potential therapeutic targets.MethodsWe performed high-throughput transcriptome sequencing on peripheral blood mononuclear cells (PBMCs) from LN patients. Healthy individuals and SLE patients without LN were used as controls. To validate the sequencing results, qRT-PCR was performed for 5 upregulated and 5 downregulated genes. Furthermore, the effect of the TNFRSF17-targeting drug IBI379 on patient plasma cells and B cells was evaluated by flow cytometry.ResultsOur analysis identified 1493 and 205 differential genes in the LN group compared to the control and SLE without LN groups respectively, with 70 genes common to both sets, marking them as LN-specific. These LN-specific genes were significantly enriched in the ‘regulation of biological quality’ GO term and the cell cycle pathway. Notably, several genes including TNFRSF17 were significantly overexpressed in the kidneys of both LN patients and NZB/W mice. TNFRSF17 levels correlated positively with urinary protein levels, and negatively with complement C3 and C4 levels in LN patients. The TNFRSF17-targeting drug IBI379 effectively induced apoptosis in patient plasma cells without significantly affecting B cells.DiscussionOur findings suggest that TNFRSF17 could serve as a potential therapeutic target for LN. Moreover, IBI379 is presented as a promising treatment option for LN.</p