30 research outputs found

    Brain areas activated in response to subjectively adjusted heat pain correlate with COMT val158met polymorphism.

    No full text
    <p>During subjectively similar intense heat pain perception (individual temperature in BPD 43°C in healthy controls), posterior parietal cortex (A), lateral globus pallidus (LGP; B) and the posterior cingulate cortex (PPC; C) displayed significant correlation with COMT-polymorphism. Labelling as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0023658#pone-0023658-g002" target="_blank">Fig. 2</a>,* p<0.05.</p

    Association between COMT genotype and fMRI activation during painful stimulation in frontal brain areas.

    No full text
    <p>Significant correlations were observed for both stimulus conditions within the dorsolateral prefrontal cortex (DLPFC; A,B). Furthermore, the posterior parietal cortex (PPC; C) and the lateral globus pallidus (LGP; D) also displayed significant correlation during both conditions. Statistics and regression lines for group means are shown in gray (all 50 subjects), black (BPD), and dashed (Control), respectively; significant Pearson product moment correlation * p<0.05, ** p<0.01, *** p<0.001, versus r = 0.</p

    Patients suffering from BPD are less heat pain sensitive independent of the <i>val158met</i> polymorphism.

    No full text
    <p>(A) Genotype distribution of the <i>val158met</i> polymorphism in healthy controls (open) and BPD patients (filled bars) do not differ. (B) Heat pain perception was markedly reduced in BPD. Dose-response function in the pretest session (circles) and stimulus temperatures applied during fMRI (squares) did significantly differ between controls and BPD (ns p>0.4; * p<0.05; ** p<0.01; *** p<0.001, students t-test).</p

    Association between COMT genotype and pain sensitivity.

    No full text
    <p>A: Lower heat pain perception in BPD in response to 43°C does not depend upon the <i>val158met</i> polymorphism. <sup>ns</sup> p>0.3, BPD and control, respectively; * p<0.05; ** p<0.01, students t-test. B: Stimulus temperatures for the induction of a heat pain sensation of NRS 40 decreases with the number of met alleles in healthy volunteers but not in BPD patients (ns p>0.19; (*) p<0.1; * p<0.05, students t-test).</p

    Results of the sensitivity analyses: a comparison of different nominal p-values.

    No full text
    <p><i>Note</i>. Results for variations of the method for the 32 Mbp width region on chromosome 5, 128–160 bp. Nom 0.01: the analysis was performed using p = 0.01 as the cutoff for nominal SNP-wise significance. Nom 0.11: the analysis was performed using p = 0.1 as the cutoff for nominal SNP-wise significance. EIGENSTRAT: the analysis was performed on data corrected for population stratification using the EIGENSTRAT procedure.</p

    “Manhattan plot of the top segment located at chromosome 5 (128–136

    No full text
    <p> <b>Mbp)”.</b> This figure shows at the y–axis the p-values of the SNPs located at chromosome 5 (128–136 Mbp). The chromosomes are shown at the x-axis. The red line indicates a p-value of 10-7, the blue line indicates a p-value of 10-5 and the green line indicates a p-value of .05.</p

    Overview of disease associated genes located within the significantly associated region at chromosome 5 (128–136 Mbp).

    No full text
    <p>Note: The table shows genes that have previously reported to be associated with disease based on the UCSC Genome Bioinformatics site (NCBI36/hg18) (<a href="http://genome.ucsc.edu/" target="_blank">http://genome.ucsc.edu/</a>) and genes previously found to be associated with schizophrenia based on the Schizophrenia Research Forum (<a href="http://www.schizophreniaresearchforum.org" target="_blank">www.schizophreniaresearchforum.org</a>). The final column represents the phenotype and disease associations according to the UCSC Genome Bioinformatics site.</p><p>Set-based tests were performed in Plink to assess the association between SNPs within a particular gene and case-control status. This test uses permutation to determine the significance. The default values were used (r-squared = .5; p-value = .05; maximum number of SNPs within a gene = 5); more details can be found at <a href="http://pngu.mgh.harvard.edu/~purcell/plink" target="_blank">http://pngu.mgh.harvard.edu/~purcell/plink</a>.</p

    Metasignificance of segments located in chromosome 5 (128–160 Mbp).

    No full text
    <p><i>Note</i>. Segment width refers to the width of regions over which tests of the number of nominally significant SNPs were tested. The replicable region indicates the location of the segment. The p-values provide the results of permutation based tests.</p

    “Manhattan plot of the 22 autosomal chromosomes”.

    No full text
    <p>This figure shows at the y–axis the p-values of the SNPs in a GWA analysis. The chromosomes are shown at the x-axis. The red line indicates a p-value of 10-7, the blue line indicates a p-value of 10-5 and the green line indicates a p-value of .05.</p
    corecore