Nickel-Catalyzed Synthesis of Diarylamines via Oxidatively Induced C–N Bond Formation at Room Temperature

A nickel-catalyzed oxidative coupling of zinc amides with organomagnesium compounds selectively produces diarylamines under mild reaction conditions, with tolerance for chloride, bromide, hydroxyl, ester, and ketone groups. A diamine is bis-monoarylated. A bromoaniline undergoes <i>N</i>-arylation followed by Kumada–Tamao–Corriu coupling in one pot. The reaction may proceed via oxidatively induced reductive elimination of a nickel species

Synthesis of Anthranilic Acid Derivatives through Iron-Catalyzed Ortho Amination of Aromatic Carboxamides with <i>N</i>‑Chloroamines

Arenes possessing an 8-quinolinylamide group as a directing group are ortho aminated with <i>N</i>-chloroamines and <i>N</i>-benzoyloxyamines in the presence of an iron/diphosphine catalyst and an organometallic base to produce anthranilic acid derivatives in high yield. The reaction proceeds via iron-catalyzed C–H activation, followed by the reaction of the resulting iron intermediate with <i>N</i>-chloroamine. The choice of the directing group and diphosphine ligand is crucial for obtaining the anthranilic acid derivative with high yield and product selectivity

Iron-Catalyzed Directed Alkylation of Aromatic and Olefinic Carboxamides with Primary and Secondary Alkyl Tosylates, Mesylates, and Halides

Alkenes, arenes, and heteroarenes possessing an 8-quinolylamide group as the directing group are alkylated with primary and secondary alkyl tosylates, mesylate, and halides in the presence of Fe­(acac)₃/diphosphine as a catalyst and ArZnBr as a base. The reaction proceeds stereospecifically for alkene substrates and takes place without loss of regiochemical integrity of the starting secondary tosylate, but with loss of the stereochemistry of the chiral center

Iron-Catalyzed Directed Alkylation of Carboxamides with Olefins via a Carbometalation Pathway

A catalytic amount of an iron salt and bipyridine ligand in the presence of an organozinc base activates the ortho C–H bond of a carboxamide, and the following reaction with an alkene such as ethylene gas (1 atm), styrene derivatives, and vinylsilane or vinylboron derivatives via carbometalation gives a putative alkylzinc intermediate. This intermediate can be further reacted with electrophiles such as deuterium oxide or allyl bromide. When monosubstituted alkenes are used as a substrate, the linear alkyl product is selectively obtained. The monoalkylated product is exclusively obtained, and dialkylation does not proceed

Additional file 1: Figure S1. of Transplantation of cultured dental pulp stem cells into the skeletal muscles ameliorated diabetic polyneuropathy: therapeutic plausibility of freshly isolated and cryopreserved dental pulp stem cells

Transplanted GFP-expressing DPSCs were located in the skeletal muscles without differentiation into adipocytes, osteoblasts, neuronal cells, or Schwann cells. DPSCs from GFP-expressing rats were transplanted into hindlimb skeletal muscles in the diabetic rats. To analyze the differentiation of transplanted DPSCs, The skeletal muscles were stained with the primary antibody against FABP for adipocytes, osteocalcin for osteoblasts, neuronal nuclei (NeuN) for neurons and glial fibrillary acidic protein for Schwann cells. (PPTX 409 kb