Multivariate logistic regression analysis.

ALT = alanine aminotransferase; ALT ratio = ALT divided by ULN for the local laboratory; ULN = upper limit of normal. aWald chi-square test for each regression coefficient; b Wald chi-square test for each variable</p

Patient selection for the development cohort.

Patient selection for the development cohort.</p

Scoring system for predictive baseline characteristics.

<p>Scoring system for predictive baseline characteristics.</p

Patient selection for the validation cohort.

<p>Patient selection for the validation cohort.</p

Rate of response in treatment-naive cirrhotic and noncirrhotic Caucasian and patients with HCV genotype 3 by baseline score.

<p>Patients with missing scores omitted (noncirrhotic; n = 48, cirrhotic; n = 11). ^a Patients with missing information on cirrhosis status were given the same score as no cirrhosis.</p

Relationship between bodyweight and sustained virologic response (SVR).

<p>Short vertical lines indicate the number of patients with SVR (black lines) and no SVR (grey lines). Open circles represent probability of SVR according to the GAM analysis. Closed circles represent empirical probability for midpoints of deciles.</p

Relationship between alanine aminotransferase (ALT)/upper limit of normal (ULN) and sustained virologic response (SVR).

<p>Short vertical lines indicate the number of patients with SVR (black lines) and no SVR (grey lines). Open circles represent probability of SVR according to the GAM analysis. Closed circles represent empirical probability for midpoints of deciles. ALT/ULN = patients' ALT divided by the ULN for the local laboratory</p

Relationship between serum hepatitis C virus RNA level and sustained virologic response (SVR).

<p>Short vertical lines indicate the number of patients with SVR (black lines) and no SVR (grey lines). Open circles represent probability of SVR according to the GAM analysis. Closed circles represent empirical probability for midpoints of deciles.</p

Rapid virologic response (RVR) and sustained virologic response by RVR status in patients with HCV genotype 3 by baseline score.

<p>A) Patients with an RVR; B) Patients without an RVR. RVR = rapid virologic response: HCV RNA <50 IU/mL by week 4 of treatment. ^a Includes patients with missing Week 4 HCV RNA results.</p

Sustained virologic response by baseline characteristic.

<p>ALT = alanine aminotransferase; ALT ratio = ALT divided by ULN for the local laboratory; ULN = upper limit of normal. P-values are based on univariate regression analysis.</p