4,792 research outputs found
Simple Recurrent Units for Highly Parallelizable Recurrence
Common recurrent neural architectures scale poorly due to the intrinsic
difficulty in parallelizing their state computations. In this work, we propose
the Simple Recurrent Unit (SRU), a light recurrent unit that balances model
capacity and scalability. SRU is designed to provide expressive recurrence,
enable highly parallelized implementation, and comes with careful
initialization to facilitate training of deep models. We demonstrate the
effectiveness of SRU on multiple NLP tasks. SRU achieves 5--9x speed-up over
cuDNN-optimized LSTM on classification and question answering datasets, and
delivers stronger results than LSTM and convolutional models. We also obtain an
average of 0.7 BLEU improvement over the Transformer model on translation by
incorporating SRU into the architecture.Comment: EMNL
Summary of a Topical Forum FAQ Based on the Chinese Composition Structure
An automatic multiple-document summarization system for producing frequently asked questions (FAQ) of a topical forum can save forum Webmasters a great deal of time in theory. This work will address summary composition issue of a previous work by proposing a structured presentation based on a four-part pattern of traditional Chinese articles. The result of the experiment shows that the enhanced system with both domain-terminology corpus methods produced a significantly better summary presentation than the original system. Recall rate and precision rate performance indices and user evaluations are also presented and discussed to show their practical implications
Morroniside Intervention Mechanism of Renal Lesions, a Combination Model of AGEs Exacerbation of STZ-Induced Diabetes Mellitus
The depth study aimed on the mechanism of morroniside in protecting diabetic nephropathy. The diabetic mice models with blood glucose above 15mmol/L were divided into model, aminoguanidine, metformin, captopril, morroniside low-dose, and morroniside high-dose groups. And normal group was set simultaneously. All groups were fed with high AGEs food except normal group. Each group was intragastric administration of the corresponding medicine except model and normal groups. After 12 weeks, all the indictors were measured. It showed that the morroniside could reduce blood glucose significantly, urinary protein, serum urea nitrogen, creatine, pathological changes, AGEs levels, renal cortex RAGE mRNA and RAGE protein expression levels; increase food consumption, water intake, urine volume, insulin secretion. As a conclusion, morroniside from cornus officinalis can protect renal in diabetic mice, its mechanism may be related to the proliferation of islet cells, rectify glycometabolism, reduce serum and kidney AGEs content, and descend renal RAGEmRNA and RAGE protein expression levels
A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter.
The principal barrier to the eradication of HIV/AIDS is the existence of latent viral reservoirs. One strategy to overcome this barrier is to use latency-reversing agents (LRAs) to reactivate the latent proviruses, which can then be eliminated by effective anti-retroviral therapy. Although a number of LRAs have been found to reactivate latent HIV, they have not been used clinically due to high toxicity and poor efficacy. In this study, we report the identification of a chalcone analogue called Amt-87 that can significantly reactivate the transcription of latent HIV provirses and act synergistically with known LRAs such as prostratin and JQ1 to reverse latency. Amt-87 works by activating the human transcriptional elongation factor P-TEFb, a CDK9-cyclin T1 heterodimer that is part of the super elongation complex (SEC) used by the viral encoded Tat protein to activate HIV transcription. Amt-87 does so by promoting the phosphorylation of CDK9 at the T-loop, liberating P-TEFb from the inactive 7SK snRNP, and inducing the formation of the Tat-SEC complex at the viral promoter. Together, our data reveal chalcones as a promising category of compounds that should be further explored to identify effective LRAs for targeted reversal of HIV latency
Direct evidence for active site-dependent formic acid electro-oxidation by topmost-surface atomic redistribution in a ternary PtPdCu electrocatalyst
The active site-dependent electrochemical formic acid oxidation was evidenced by the increased coverage of Pt in the topmost mixed PtPd alloy layer of ternary PtPdCu upon potential cycling, which demonstrated two catalytic pathways only in one catalyst owing to surface atomic redistribution in an acidic electrolyte environment
The application research on improvement of genetic algorithm in linear CCD detection
When the linear array image sensor (CCD) is used for spot detection, the optimization of the detection signal is usually one of the problems that plague the user. In linear array imaging sensor (CCD) detection applications, optimization of the detection signal is usually one of the problems with the user. Based on the characteristics of linear array CCD detection signal, a genetic algorithm (GA) is established to solve the problem of mathematical model. In this paper, a new adaptive genetic algorithm (IGA) with directional adaptive guidance and adaptive control technology and threshold constraint technology are proposed for the lack of local optimization ability of the standard genetic algorithm (SGA), premature convergence and low accuracy. By applying IGA to the actual detection data, it is proved that IGA has certain advantages in solving the problem of linear CCD detection signal optimization. In the end of this paper, the performance of IGA, SGA and peak finding algorithm (SP) are analyzed and compared, which fully demonstrates the advantages of IGA in solving such problems
CDIO-CT collaborative strategy for solving complex STEM problems in system modeling and simulation: an illustration of solving the period of mathematical pendulum
The problem-project-oriented STEM education plays a significant role in
training students' ability of innovation. Although the
conceive-design-implement-operate (CDIO) approach and the computational
thinking (CT) are hot topics in recent decade, there are still two
deficiencies: the CDIO approach and CT are discussed separately and a general
framework of coping with complex STEM problems in system modeling and
simulation is missing. In this paper, a collaborative strategy based on the
CDIO and CT is proposed for solving complex STEM problems in system modeling
and simulation with a general framework, in which the CDIO is about ``how to
do", CT is about ``how to think", and the project means ``what to do". As an
illustration, the problem of solving the period of mathematical pendulum (MP)
is discussed in detail. The most challenging task involved in the problem is to
compute the complete elliptic integral of the first kind (CEI-1). In the
philosophy of STEM education, all problems have more than one solutions. For
computing the CEI-1, four methods are discussed with a top-down strategy, which
includes the infinite series method, arithmetic-geometric mean (AGM) method,
Gauss-Chebyshev method and Gauss-Legendre method. The algorithms involved can
be utilized for R & D projects of interest and be reused according to the
requirements encountered. The general framework for solving complex STEM
problem in system modeling and simulation is worth recommending to the college
students and instructors.Comment: 27 pages, 12 figures, 11 table
1,3-Diprop-2-ynyl-1H-imidazol-3-ium bromide
In the title salt, C9H9N2
+·Br−, the ethynyl groups are nearly antiÂparallel to each other [the angle between the two ethynyl groups is179.7 (2)°]. No classical hydrogen bonds or π–π interÂactions are observed. The molÂecules are linked by C—H⋯Br hydrogen bonds. The bromide anions are involved in interÂactions with three H atoms
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