The effect of supportive work environment and workplace diversity on employee engagement in hotel industry

Diversity at workplace was studied in many contexts but it has limited studies for employee engagement in the hotel industry. The purpose of this study is to identify the effect of supportive work environment and workplace diversity on employee engagement. A total of 179 hotel employees from Kedah states were participated in this study. The collected data were analysed using the Statistical Package for Social Science (SPSS) version 26. This study found no significant relationship between supportive work environment and employee engagement whereas, workplace diversity has significant influence on workplace diversity. Thus, it is crucial for the organization to put a great emphasize on the significant roles on workplace diversity to increased employee’s engagement in hotel industry in Kedah are

Tactile Aware Dynamic Obstacle Avoidance in Crowded Environment with Deep Reinforcement Learning

Mobile robots operating in crowded environments require the ability to navigate among humans and surrounding obstacles efficiently while adhering to safety standards and socially compliant mannerisms. This scale of the robot navigation problem may be classified as both a local path planning and trajectory optimization problem. This work presents an array of force sensors that act as a tactile layer to complement the use of a LiDAR for the purpose of inducing awareness of contact with any surrounding objects within immediate vicinity of a mobile robot undetected by LiDARs. By incorporating the tactile layer, the robot can take more risks in its movements and possibly go right up to an obstacle or wall, and gently squeeze past it. In addition, we built up a simulation platform via Pybullet which integrates Robot Operating System (ROS) and reinforcement learning (RL) together. A touch-aware neural network model was trained on it to create an RL-based local path planner for dynamic obstacle avoidance. Our proposed method was demonstrated successfully on an omni-directional mobile robot who was able to navigate in a crowded environment with high agility and versatility in movement, while not being overly sensitive to nearby obstacles-not-in-contact

Identification of Soil Microbes Capable of Utilizing Cellobiosan

Approximately 100 million tons of anhydrosugars, such as levoglucosan and cellobiosan, are produced through biomass burning every year. These sugars are also produced through fast pyrolysis, the controlled thermal depolymerization of biomass. While the microbial pathways associated with levoglucosan utilization have been characterized, there is little known about cellobiosan utilization. Here we describe the isolation and characterization of six cellobiosan-utilizing microbes from soil samples. Each of these organisms is capable of using both cellobiosan and levoglucosan as sole carbon source, though both minimal and rich media cellobiosan supported significantly higher biomass production than levoglucosan. Ribosomal sequencing was used to identify the closest reported match for these organisms:Sphingobacterium multivorum, Acinetobacter oleivorans JC3-1, Enterobacter sp SJZ-6, andMicrobacterium sps FXJ8.207 and 203 and a fungal species Cryptococcus sp. The commercially-acquired Enterobacter cloacae DSM 16657 showed growth on levoglucosan and cellobiosan, supporting our isolate identification. Analysis of an existing database of 16S rRNA amplicons from Iowa soil samples confirmed the representation of our five bacterial isolates and four previously-reported levoglucosan-utilizing bacterial isolates in other soil samples and provided insight into their population distributions. Phylogenetic analysis of the 16S rRNA and 18S rRNA of strains previously reported to utilize levoglucosan and our newfound isolates showed that the organisms isolated in this study are distinct from previously described anhydrosugar-utilizing microbial species

Psychosocial Determinants of Knee Osteoarthritis Progression: Results from the Promoting Independence in Our Seniors with Arthritis Study

Background Knee osteoarthritis (OA) is a common cause of physical disability among older adults. While established risk factors for knee OA include age and increased body weight, few studies have examined psychosocial risk factors or progression of knee OA. Methods The Promoting Independence in our Seniors with Arthritis study recruited participants aged 65 years and over from orthopedic outpatients and community engagement events. Participants were invited to annual visits during which knee OA symptoms were assessed with the Knee Injury and Osteoarthritis Outcome Score (KOOS), social network using the 6-item Lubben Social Network Scale and anxiety and depression using the Hospital Anxiety and Depression scale. Knee OA worsening was defined by a 5% reduction in mean KOOS scores at the last visit compared to the first visit. Results Data were available from 148 participants, mean age 66.2±6.5 years and 74.1% female, of whom 28 (18.9%) experienced OA worsening over a median follow-up period of 29 months. Univariate analyses revealed that age, sex, height, grip strength, and social network were associated with OA worsening. Social network remained statistically significantly associated with OA worsening after adjustment for age and sex difference (odds ratio=0.924; 95% confidence interval, 0.857–0.997). The relationship between social network and OA worsening were attenuated by both depression and handgrip strength at baseline. Conclusion Psychological status and muscle strength may be modifiable risk factors for social network which may in turn prevent knee OA worsening and should be targeted in future intervention studies

Replication and Meta-analysis of the Association between BDNF Val66Met Polymorphism and Cognitive Impairment in Patients Receiving Chemotherapy.

Cancer-related cognitive impairment (CRCI) adversely affects cancer patients. We had previously demonstrated that the BDNF Val66Met genetic polymorphism is associated with lower odds of subjective CRCI in the multitasking and verbal ability domains among breast cancer patients receiving chemotherapy. To further assess our previous findings, we evaluated the association of BDNF Val66Met polymorphism with subjective and objective CRCI in a temporally separate cohort of patients and pooled findings from both the original (n = 145) and current (n = 193) cohorts in a meta-analysis. Subjective CRCI was assessed using FACT-Cog. Objective CRCI was evaluated using computerized neuropsychological tests. Genotyping was carried out using Sanger sequencing. The association of BDNF Val66Met genotypes and CRCI was examined with logistic regression. A fixed-effect meta-analysis was conducted using the inverse variance method. In the meta-analysis (n = 338), significantly lower odds of CRCI were associated with Met allele carriers based on the global FACT-Cog score (OR = 0.52, 95% CI 0.29-0.94). Furthermore, Met allele carriers were at lower odds of developing impairment in the domains of memory (OR = 0.34, 95% CI: 0.17-0.70), multitasking (OR = 0.33, 95% CI: 0.18-0.59), and verbal ability (OR = 0.46, 95% CI: 0.24-0.88). Consistent with the previous study, lower odds of subjective CRCI among patients with the BDNF Met allele was observed after adjusting for potential confounders in the multitasking (OR = 0.30, 95% CI: 0.14-0.67) domain. In conclusion, carriers of the BDNF Met allele were protected against global subjective CRCI, particularly in the domains of memory, multitasking, and verbal ability. Our findings further contribute to the understanding of CRCI pathophysiology

Adaptive structural design of river monitoring systems: Enhancing environmental monitoring capabilities and sustainability

The accelerating degradation of river ecosystems due to pollution necessitates the innovation of River Monitoring Systems (RMS) to protect these critical waterways. This research presents a novel design for adaptive RMS camera structures, aimed at enhancing monitoring capabilities and addressing the limitations of current systems. Highlighting the essential role rivers play in sustaining biodiversity, our study underscores the severe consequences of pollution, as exemplified by the deteriorating condition of Malaysia’s Klang River. We identify the need for a flexible RMS structure to overcome challenges such as excessive weight, corrosion susceptibility, and maintenance difficulties. Our methodology integrates advanced 3D Drawing Software for structural design, Fusion 360 for weight analysis, and a combination of manual calculations and simulations for vibration analysis. The findings reveal that Carbon Fiber Reinforced Polymers (CFRP) are the optimal material choice, offering an excellent balance of performance and cost-efficiency. This research successfully develops a structurally sound, user-friendly, and dynamically stable RMS camera structure, significantly advancing environmental monitoring practices. The study's contributions provide a foundation for future innovations in adaptive structural design, with broad implications for safeguarding river ecosystems worldwide

The New Norms of Cosmetic Surgery among Youth in Malaysia

Aesthetics is a complex concept that makes it hard for humans to define beauty. Beauty is a relative term and varies from person to person. The desire to be beautiful is natural among most human beings nowadays. The main objective to conduct this research was to study the views of cosmetic surgery among youth in Malaysia. The specific objectives were to explore the causes that drive youth to undergo cosmetic surgery, to find out the physical and psychological effects on youth who underwent cosmetic surgery and to analyze the acceptance of cosmetic surgery as a common norm and an accepted form of self-improvement. This research focused on youth who underwent cosmetic surgery, between the ages of 15 to 40 years olds in Malaysia. The qualitative method chosen for this research was faceto-face interviews on four respondents using open-ended questions to obtain real data. This study informed about diverse perspectives of beauty which were held by different people from various backgrounds. The factors that influence youth were to enhance their appearance encountering the criticisms from public and to boost their confidence. However, the effects of doing so could be devastating as the risks are unpredictable. It is recommended that future research on this topic may include more respondents of diverse ages especially older men and women to find the extent of the factors

Transient bilateral abducens neuropathy with post-tetanic facilitation and acute hypokalemia associated with oxaliplatin: a case report

<p>Abstract</p> <p>Introduction</p> <p>Oxaliplatin is a cytotoxic platinum compound that is in widespread use in the treatment of gastrointestinal cancers. It has been occasionally associated with acute motor neuropathy, but the precise mechanism is uncertain. To the best of our knowledge, we report the first case of a patient demonstrating post-tetanic facilitation in the setting of transient bilateral abducens neuropathy and hypokalemia, after being infused with oxaliplatin.</p> <p>Case presentation</p> <p>A 47-year-old Indian woman with metastatic gastric cancer was receiving an oxaliplatin infusion at the initiation of her third cycle of palliative chemotherapy. She developed acute bilateral abducens neuropathy with post-tetanic facilitation alongside acute laryngopharyngodysesthesia and hypokalemia. Following supportive management, including potassium infusion and warming, her neurological signs and symptoms were spontaneously resolved. This syndrome did not recur in subsequent cycles following prolongation of infusion duration and the addition of supportive calcium and magnesium infusions.</p> <p>Conclusion</p> <p>The novel clinical observation of post-tetanic facilitation highlights a possible involvement of voltage-gated channels at the presynaptic terminals in the mechanism of acute oxaliplatin neurotoxicity.</p

Evasion of anti-growth signaling: a key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds

The evasion of anti-growth signaling is an important characteristic of cancer cells. In order to continue to proliferate, cancer cells must somehow uncouple themselves from the many signals that exist to slow down cell growth. Here, we define the anti-growth signaling process, and review several important pathways involved in growth signaling: p53, phosphatase and tensin homolog (PTEN), retinoblastoma protein (Rb), Hippo, growth differentiation factor 15 (GDF15), AT-rich interactive domain 1A (ARID1A), Notch, insulin-like growth factor (IGF), and Krüppel-like factor 5 (KLF5) pathways. Aberrations in these processes in cancer cells involve mutations and thus the suppression of genes that prevent growth, as well as mutation and activation of genes involved in driving cell growth. Using these pathways as examples, we prioritize molecular targets that might be leveraged to promote anti-growth signaling in cancer cells. Interestingly, naturally-occurring phytochemicals found in human diets (either singly or as mixtures) may promote anti-growth signaling, and do so without the potentially adverse effects associated with synthetic chemicals. We review examples of naturally-occurring phytochemicals that may be applied to prevent cancer by antagonizing growth signaling, and propose one phytochemical for each pathway. These are: epigallocatechin-3-gallate (EGCG) for the Rb pathway, luteolin for p53, curcumin for PTEN, porphyrins for Hippo, genistein for GDF15, resveratrol for ARID1A, withaferin A for Notch and diguelin for the IGF1-receptor pathway. The coordination of anti-growth signaling and natural compound studies will provide insight into the future application of these compounds in the clinical setting