Maximun GEM leaks in the systemic circulation during the ILP procedure (combination of 20 and 100 µg/ml groups, n = 14).

<p>Maximun GEM leaks in the systemic circulation during the ILP procedure (combination of 20 and 100 µg/ml groups, n = 14).</p

Dose-response curves after in vitro exposure for 30 min of CRC cells SW480, HT28, HCT116 and HCT8 with the lung effluent collected at the end of the ILP procedure.

<p>Cells were exposed to different dilutions (10%, 50% and 100%) of the lung effluent.</p

Figure 3

<p>A- Perfusion inflow in the isolated lung perfused with gelatin (580±178.88 ml/min), GEM 20 µg/ml (257.14±202.62 ml/min) and GEM 100 µg/ml (210+/−138.92 ml/min) during 30 min (p = 0.0055). B- Perfusion pressure in the isolated lung perfused with gelatin, GEM 20 µg/ml, and GEM 100 µg/ml during 30 min. C- Mean left pulmonary artery pressure before and after ILP with gelatin, GEM 20 µg/ml and GEM 100 µg/ml during 30 min (p = 0.7187).</p

Renal and hepatic functions of the animals at the end of the ILP and after one month of survival.

<p><i>ALAT</i> alanine aminotransferase, <i>Alk Ph</i> alkaline phosphatase, <i>ASAT</i> aspartate aminotransferase, <i>Creat</i> creatinemia.</p

Mutation status of CRC cell lines tested in vitro.

<p>Mutation status of CRC cell lines tested in vitro.</p

Figure 1

<p>A- IC50 values after in vitro exposure for 30 min of CRC cells SW480, HT28, HCT116 and HCT8 with Oxaliplatin, 5 FU, Cisplatin, GEM, Irinotecan and Raltitrexed. B- Dose-response curves after in vitro exposure for 30 min of CRC cells SW480, HT28, HCT116 and HCT8 with Oxaliplatin, 5 FU, Cisplatin, GEM, Irinotecan and Raltitrexed. C- Dose-response curves after in vitro exposure for 30 min of CRC cells SW480, HT28, HCT116 and HCT8 with combination of GEM and Raltitrexed.</p

Hemodynamic and respiratory parameters during ILP procedure.

<p>Hemodynamic and respiratory parameters during ILP procedure.</p

Receiver operating characteristic curve of serum procalcitonin (PCT) for the diagnosis of gram negative bacteremia in critically ill patients with clinical sepsis and blood cultures proven positive for bacterial species

Plain circles indicate PCT values and dashes represents the corresponding ROC curve assuming a normal distribution of the variable.<p><b>Copyright information:</b></p><p>Taken from "Serum procalcitonin elevation in critically ill patients at the onset of bacteremia caused by either gram negative or gram positive bacteria"</p><p>http://www.biomedcentral.com/1471-2334/8/38</p><p>BMC Infectious Diseases 2008;8():38-38.</p><p>Published online 26 Mar 2008</p><p>PMCID:PMC2289831.</p><p></p

Chiang scores at the end of the ILP procedure and one month later.

<p>Chiang scores at the end of the ILP procedure and one month later.</p

Additional file 2: of RAS status and neoadjuvant chemotherapy impact CD8+ cells and tumor HLA class I expression in liver metastatic colorectal cancer

Figure S1. Immune parameters correlation. Figure S2. Impact of Ras-Raf mutationnal status tumor environment. Figure S3. HLA score and CD8 positive cells combination as prognostic factor. Figure S4. Impact of neoadjuvant chemotherapy on immune infiltrates. Figure S5. CD8+ cells’ recruitment modifies tumor stroma making mCRC elligible for immune therapeutic intervention. (ZIP 430 kb