Processing of stacked NPs in embedded sentences in Malayalam

The paper examines the effect of stacked NPs in centre-embedded sentences in Malayalam and uses the experimental results to compare two theories of processing difficulty: Gibson (2000)’s Dependency Locality Theory (DLT) and Hale (2001)’s Surprisal Theory. Crucially, the study also looks at the definite vs. non-definite NP distinction in Malayalam in a stacked NP context. Non-definiteness in Malayalam is indicated by having the determiner oru before the noun; a non-definite NP in a centre-embedded sentence disrupts NP stacking. A self-paced reading task is run using single and double-embedded sentences in Malayalam with the embedded NP alternating between definite and non-definite conditions. The test is designed to determine if (i) stacked NPs in a centre-embedded sentence result in a processing difficulty (ii) having oru preceding an NP affects processing. The results showed that processing difficulty increases with the addition of each NP; NPs from the embedded clauses take longest to be read. When the embedded NP is preceded by oru, reaction time significantly drops at oru and the following NP, indicating that the determiner facilitated integration of theNP, disrupting NP stacking. The results were compared against the predictions of DLT and Surprisal models. We found that the anticipation based Surprisal account best accounted for the results for Malayalam.&nbsp

To Administer Of Child With Grand Protection By Using Internet Of Things

Although much work has been done to date to learn about the Internet of Things (IoT) in practice, Maximum Panels makes a habitat of resource-constrained nodes, rather than adding existing embedded structures to the Internet of Things (IoT) network to couple. The proposed tool envisages the Wi-Fi technology of the tool in the form of a built-in tool, specifically ARM for the child, which serves as the cause of indications and the way to talk to easy channels and the photo with the digital virtual to take camera. There is much Android security software for toddlers, but it is no longer like heaps of inexperienced. To solve the child protection problem, we have expanded the easy and powerful Wi-Fi sensor setup to help the victim. Even with the button for the victim groups, the tool will capture the photo, get user statistics to send a notification to the registered cell phone numbers with the link to the image. It saves time and that victim gets help without wasting time. Also in the case of child protection, the device proposes to provide speed detection and monitoring facilities for adjacent areas using GPS and GSM

A Study on The Awareness of Consanguinity & Various Genetic Aspects Among the Parents of Children with Beta Thalassemia and To Understand the Usefulness of Various Indices in Identifying Beta Thalassemia Carriers in A Cohort of South Indian Patients

Background: Beta thalassemia is one of the common single gene disorders in India. Screening relies on High performance Liquid Chromatography (HPLC) / Hemoglobin electrophoresis. But this being an expensive test, we looked at the usefulness of red blood cell indices in the identification of beta thalassemia carriers. We have also looked at the proportion of consanguinity and the awareness of genetic aspects of Beta thalassemia in this cohort. Methods: This is an observational study among parents of children with Beta thalassemia major attending hematology out-patient Department in a tertiary care centre in Chennai, South India. Their complete hemograms were analysed using Mentzer Index, Srivastava Index and Green & King Index. They were also asked to fill in a questionnaire to understand their level of awareness of Beta thalassemia, consanguinity and other demographic parameters. Results: Though the three indices were able to identify majority of the carriers, they missed 10-20% of carriers underscoring the fact that Complete Blood counts and HPLC together would remain the best modality.53% of this cohort were graduates and 26.7% were consanguineous. None of the parents had heard of thalassemia before their child’s diagnosis.53.3% understood the genetic nature of this disorder. Conclusion: Evaluating complete hemogram and HPLC would be the ideal screening method to identify Beta thalassemia carriers. More awareness needs to be initiated in the community about Beta thalassemia and universal screening for Beta thalassemia in all adults >18 years or at least for antenatal mothers should be initiated at the earliest

4-[(4′-Chloro­methyl-[1,1′-biphen­yl]-4-yl)meth­yl]bis­(dimethyl­glyoximato-κ2 N,N′)(pyridine-κN)cobalt(III)1

The title compound, [Co(C14H14Cl)(C4H6N2O2)2(C5H5N)], is a model compound for the more complex cobalamines like vitamins B12. The CoIII atom is coordinated by a (4′-chloro­methyl-[1,1′-biphen­yl]-4-yl)methyl group, an N-bonded pyridine and two N,N′-bidentate dimethyl­glyoximate ligands in a distorted octa­hedral geometry. The glyoximate ligands exhibit intra­molecular O—H⋯O hydrogen bonds, which is very common in cobaloxime derivatives

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570