Image_1_Case report: Recovery of hallucinations and cognitive impairment after administration of donepezil in a patient with schizophrenia and carbon monoxide poisoning.png

ObjectivesThis report aims to introduce a rare case of a dramatic recovery by donepezil with a patient with schizophrenia who suffered from remaining psychotic symptoms despite proper treatment and had a cognitive impairment by carbon monoxide (CO) poisoning sequelae.Case reportA 38-year-old male who developed schizophrenia 2 years ago had attempted suicide via CO inhalation due to his uncontrolled symptoms. He was hospitalized with delayed neurological sequelae (DNS). Though hyperbaric oxygen therapy (HBOT) was applied 10 times, his cognitive impairment did not recover. Surprisingly, with 5–10 mg donepezil, both cognitive function and the psychotic symptoms of the patient remarkably improved.ConclusionThis case showed a good response of donepezil for a patient with schizophrenia and CO-induced DNS after ineffective HBOT. Although the mechanism of the phenomenon is unclear, it can be possible reasons that the neuroprotective effect of donepezil and white matter insult by CO poisoning.</p

Demographic and clinical characteristics.

Demographic and clinical characteristics.</p

Tract-based spatial statistics analyses identified white matter areas affected by a significant decrease in fractional anisotropy (FA) in patients with psychotic bipolar disorder (PBD) (N = 29), non-psychotic bipolar disorder (NPBD) (N = 23), and bipolar disorder (BD) (N = 52) in comparisons with healthy controls (HCs) (N = 65).

Family-wise error corrected P < 0.0062.</p

Comparisons of fractional anisotropy among PBD (N = 29), NPBD (N = 23), BD (PBD + NPBD) (N = 52), and HC (N = 65) groups^a.

Comparisons of fractional anisotropy among PBD (N = 29), NPBD (N = 23), BD (PBD + NPBD) (N = 52), and HC (N = 65) groupsa.</p

Trends in the numbers of suicides per month between 1997 and 2018 in Korea.

The dots represent the numbers of suicides and the red dashed line indicates the trend. The blue vertical dotted lines indicate the dates of celebrity suicides. (TIF)</p

Comparisons of mean diffusivity among PBD (N = 29), NPBD (N = 23), BD (PBD + NPBD) (N = 52), and HC (N = 65) groups^a.

Comparisons of mean diffusivity among PBD (N = 29), NPBD (N = 23), BD (PBD + NPBD) (N = 52), and HC (N = 65) groupsa.</p

Tract-based spatial statistics analyses identified white matter areas affected by a significant increase in mean diffusivity (MD) in patients with psychotic bipolar disorder (PBD) (N = 29), non-psychotic bipolar disorder (NPBD) (N = 23), and bipolar disorder (BD) (N = 52) in comparisons with healthy controls (HCs) (N = 65).

Family-wise error corrected P < 0.0062.</p

Trends in the numbers of suicides by age group per month between 1997 and 2018 in Korea.

The dots represent the numbers of suicides and the red dashed line indicates the trend. The blue vertical dotted lines indicate the dates of celebrity suicides. (TIF)</p

Observed and expected numbers of suicides by age group per month between 2017 and 2020 in Korea.

The red line with circles represents the observed number of suicides between 2017 and 2020. The blue line with triangles represents the expected number of suicides according to forecasting models and the surrounding blue area indicates the 95% confidence interval (with 2019 as the validation period). The blue vertical dotted lines indicate the dates of celebrity suicides.</p

Presentation_1_Differential predictors of early- and delayed-onset post-traumatic stress disorder following physical injury: a two-year longitudinal study.pdf

ObjectivesThis study aimed to investigate the predictors of both early- and delayed-onset PTSD over a 2-year period following physical injuries.MethodsPatients were recruited from a trauma center at a university hospital in South Korea (June 2015 ~ January 2021). At baseline, 1142 patients underwent comprehensive assessments including socio-demographic, pre-trauma, trauma-related, and peri-trauma evaluations. Diagnoses of acute stress disorder (ASD) and subthreshold ASD were also determined using the Clinician-administered PTSD Scale (CAPS). Follow-up assessments at three months included diagnoses of PTSD and subthreshold PTSD using CAPS, and stressful life events (SLEs), with additional evaluations at 6, 12, and 24 months. The analyzed sample comprised 1014 patients followed up at least once after the baseline and 3-month evaluations. PTSD diagnoses were categorized into early-onset (within the first six months after trauma) and delayed-onset (more than six months after trauma). Logistic regression models identified predictors for each group.ResultsEarly-onset and delayed-onset PTSD were diagnosed in 79 and 35 patients, respectively. Early-onset PTSD was predicted by previous psychiatric disorders, previous traumatic events, ASD and subthreshold ASD diagnoses, and higher anxiety levels. In contrast, delayed-onset PTSD was linked to higher education, higher injury severity, and subthreshold PTSD and SLEs at 3-month follow-up.ConclusionDistinct predictors were found for early-onset and delayed-onset PTSD. The findings underscore the heterogeneous factors influencing the temporal development of PTSD post-trauma, and may provide valuable guidance for more targeted interventions and improved patient outcomes.</p