1 research outputs found
Synthesis of a Novel BODIPY Library and Its Application in the Discovery of a Fructose Sensor
We prepared a new library of 160 compounds by conjugation
of a
BODIPY core to a collection of aldehydes. This library was screened
against 52 biologically relevant analytes and we identified one fluorescent
sensor of fructose (Fructose Orange). Fructose Orange showed a 24-fold
fluorescence increase upon recognition of fructose and an outstanding
selectivity among 24 different saccharides. NMR studies confirmed
that five different binding interactions were formed between the sensor
and fructose. Furthermore, Fructose Orange was applied to the quantification
of fructose in soft drinks, being the most selective fluorescent sensor
for fructose reported to date