Affordable Housing and Transportation Cost Burdens in San Diego County

The State of California has increasingly urged construction of affordable housing development in transit-rich areas (California Department of Housing and Community Development 2024) but so far transit-oriented development has generally not reduced vehicle miles traveled for low-income renters (Chatman et al. 2019; Lund, Cervero, and Willson 2004). This report quantifies the cost of daily travel needs for affordable housing residents in San Diego, California, especially seniors aged 62 and older, in two ways. First, it analyzes their trip travel time for the entire San Diego region using activity-based model (ABM) data. Second, it summarizes results from surveys of residents in six affordable housing buildings, three of which provide supportive housing to seniors. Overall, it finds that affordable housing residents use public transit more often than those who have access to a car. But traveling by public transit takes much longer on public transit than traveling by personal vehicle. Survey respondents under age 62 expressed greater dissatisfaction with the costs of public transit ridership, compared to seniors, and were also more likely to express dissatisfaction if they were working. Seniors were more likely to express dissatisfaction with the conditions of public transit stops

Microbial Biomarkers in Liquid Biopsy for Cancer: An Overview and Future Directions

In recent years, the relationship between microbes and tumors has led to a new wave of scholarly pursuits. Due to the growing awareness of the importance of microbiota, including those within tumors, for cancer onset, progression, metastasis, and treatment, researchers have come to understand that microbiota and the tumor microenvironment together form a dynamic and complex ecosystem. Liquid biopsy technology, a non-invasive and easily repeatable method for sample collection, combined with emerging multi-omics techniques, allows for a more comprehensive and in-depth exploration of microbial signals and characteristics in bodily fluids. Microbial biomarkers hold immense potential in the early diagnosis, treatment stratification, and prognosis prediction of cancer. In this review, we describe the significant potential of microbial biomarkers in liquid biopsy for clinical applications in cancer, including early diagnosis, predicting treatment responses, and prognosis. Moreover, we discuss current limitations and potential solutions related to microbial biomarkers. This review aims to provide an overview and future directions of microbial biomarkers in liquid biopsy for cancer clinical practice