Quantifying Performance of Bipedal Standing with Multi-channel EMG

Spinal cord stimulation has enabled humans with motor complete spinal cord injury (SCI) to independently stand and recover some lost autonomic function. Quantifying the quality of bipedal standing under spinal stimulation is important for spinal rehabilitation therapies and for new strategies that seek to combine spinal stimulation and rehabilitative robots (such as exoskeletons) in real time feedback. To study the potential for automated electromyography (EMG) analysis in SCI, we evaluated the standing quality of paralyzed patients undergoing electrical spinal cord stimulation using both video and multi-channel surface EMG recordings during spinal stimulation therapy sessions. The quality of standing under different stimulation settings was quantified manually by experienced clinicians. By correlating features of the recorded EMG activity with the expert evaluations, we show that multi-channel EMG recording can provide accurate, fast, and robust estimation for the quality of bipedal standing in spinally stimulated SCI patients. Moreover, our analysis shows that the total number of EMG channels needed to effectively predict standing quality can be reduced while maintaining high estimation accuracy, which provides more flexibility for rehabilitation robotic systems to incorporate EMG recordings

Safe Exploration for Optimization with Gaussian Processes

We consider sequential decision problems under uncertainty, where we seek to optimize an unknown function from noisy samples. This requires balancing exploration (learning about the objective) and exploitation (localizing the maximum), a problem well-studied in the multi-armed bandit literature. In many applications, however, we require that the sampled function values exceed some prespecified "safety" threshold, a requirement that existing algorithms fail to meet. Examples include medical applications where patient comfort must be guaranteed, recommender systems aiming to avoid user dissatisfaction, and robotic control, where one seeks to avoid controls causing physical harm to the platform. We tackle this novel, yet rich, set of problems under the assumption that the unknown function satisfies regularity conditions expressed via a Gaussian process prior. We develop an efficient algorithm called SafeOpt, and theoretically guarantee its convergence to a natural notion of optimum reachable under safety constraints. We evaluate SafeOpt on synthetic data, as well as two real applications: movie recommendation, and therapeutic spinal cord stimulation

Clinical Online Recommendation with Subgroup Rank Feedback

Many real applications in experimental design need to make decisions online. Each decision leads to a stochastic reward with initially unknown distribution. New decisions are made based on the observations of previous rewards. To maximize the total reward, one needs to solve the tradeoff between exploring different strategies and exploiting currently optimal strategies. This kind of tradeoff problems can be formalized as Multi-armed bandit problem. We recommend strategies in series and generate new recommendations based on noisy rewards of previous strategies. When the reward for a strategy is difficult to quantify, classical bandit algorithms are no longer optimal. This paper, studies the Multi-armed bandit problem with feedback given as a stochastic rank list instead of quantified reward values. We propose an algorithm for this new problem and show its optimality. A real application of this algorithm on clinical treatment is helping paralyzed patient to regain the ability to stand on their own feet

Correlational Dueling Bandits with Application to Clinical Treatment in Large Decision Spaces

We consider sequential decision making under uncertainty, where the goal is to optimize over a large decision space using noisy comparative feedback. This problem can be formulated as a K-armed Dueling Bandits problem where K is the total number of decisions. When K is very large, existing dueling bandits algorithms suffer huge cumulative regret before converging on the optimal arm. This paper studies the dueling bandits problem with a large number of arms that exhibit a low-dimensional correlation structure. Our problem is motivated by a clinical decision making process in large decision space. We propose an efficient algorithm CorrDuel which optimizes the exploration/exploitation tradeoff in this large decision space of clinical treatments. More broadly, our approach can be applied to other sequential decision problems with large and structured decision spaces. We derive regret bounds, and evaluate performance in simulation experiments as well as on a live clinical trial of therapeutic spinal cord stimulation. To our knowledge, this marks the first time an online learning algorithm was applied towards spinal cord injury treatments. Our experimental results show the effectiveness and efficiency of our approach

Multi-dueling Bandits with Dependent Arms

The dueling bandits problem is an online learning framework for learning from pairwise preference feedback, and is particularly well-suited for modeling settings that elicit subjective or implicit human feedback. In this paper, we study the problem of multi-dueling bandits with dependent arms, which extends the original dueling bandits setting by simultaneously dueling multiple arms as well as modeling dependencies between arms. These extensions capture key characteristics found in many real-world applications, and allow for the opportunity to develop significantly more efficient algorithms than were possible in the original setting. We propose the selfsparring algorithm, which reduces the multi-dueling bandits problem to a conventional bandit setting that can be solved using a stochastic bandit algorithm such as Thompson Sampling, and can naturally model dependencies using a Gaussian process prior. We present a no-regret analysis for multi-dueling setting, and demonstrate the effectiveness of our algorithm empirically on a wide range of simulation settings

Preference-Based Learning for Exoskeleton Gait Optimization

This paper presents a personalized gait optimization framework for lower-body exoskeletons. Rather than optimizing numerical objectives such as the mechanical cost of transport, our approach directly learns from user preferences, e.g., for comfort. Building upon work in preference-based interactive learning, we present the CoSpar algorithm. CoSpar prompts the user to give pairwise preferences between trials and suggest improvements; as exoskeleton walking is a non-intuitive behavior, users can provide preferences more easily and reliably than numerical feedback. We show that CoSpar performs competitively in simulation and demonstrate a prototype implementation of CoSpar on a lower-body exoskeleton to optimize human walking trajectory features. In the experiments, CoSpar consistently found user-preferred parameters of the exoskeleton’s walking gait, which suggests that it is a promising starting point for adapting and personalizing exoskeletons (or other assistive devices) to individual users

Stagewise Safe Bayesian Optimization with Gaussian Processes

Enforcing safety is a key aspect of many problems pertaining to sequential decision making under uncertainty, which require the decisions made at every step to be both informative of the optimal decision and also safe. For example, we value both efficacy and comfort in medical therapy, and efficiency and safety in robotic control. We consider this problem of optimizing an unknown utility function with absolute feedback or preference feedback subject to unknown safety constraints. We develop an efficient safe Bayesian optimization algorithm, StageOpt, that separates safe region expansion and utility function maximization into two distinct stages. Compared to existing approaches which interleave between expansion and optimization, we show that StageOpt is more efficient and naturally applicable to a broader class of problems. We provide theoretical guarantees for both the satisfaction of safety constraints as well as convergence to the optimal utility value. We evaluate StageOpt on both a variety of synthetic experiments, as well as in clinical practice. We demonstrate that StageOpt is more effective than existing safe optimization approaches, and is able to safely and effectively optimize spinal cord stimulation therapy in our clinical experiments