Pengujian akurasi model regresi logistik multinomial untuk memprediksi keberhasilan mahasiswa di perguruan tinggi menggunakan r

Higher education institute should have maintained its student’s success in their academic field. Therefore, higher education institute should make a model to predict its success as early as possible. To have such model, the impacting factors should be determined, which factor are in the forms of continuous dan categorized data. This research is aimed to build logistic regression model based on compounded data from continuous and categorized data, which then test the model accuracy to predict the student’s success in such institute. Research data is using 68 student’s data. There are 6 research steps, first, data preparation and collection, second, data analysis, third, building the logistic multinomial regression model, fourth, data testing and validation, fifth, measure the model accuracy, and the sixth step is drawing the conclusion based on the analysis output. The result of prediction analysis dan accuracy test using logistic multinomial regression is the best model with significant factors that influence the study time are gender, department and selection track, while prediction accuracy model for each study time response variable is 96.4%

Pengembangan Sistem Informasi Manajemen Rumah Makan (Simrahman) Studi Kasus Rumah Makan Memory Garden Purwokerto

Economic competition is very tight now, especially for restaurant. The manager as restaurant policy control always has to get accurate informations and up to date. The Memory Garden Restaurant was one of restaurant that was located in Purwokerto. Previously, every operational activity and restaurant report still applied manual system by using paper. That system could be difficult for employees to give services for the customers, especially when there are many customers come. The manager got difficulty to investigate stack of data at the paper in large number for getting informations. It could be taken benefit by employees to do dishonest. To solve these problems, Memory Garden Restaurant needs management information system. Incremental model has been taken as process model to build the new system. This restaurant management information system, or called SIMRAHMAN, has been developed using programming language of Visual Basic.NET and DBMS of MySql. SIMRAHMAN can support working for all employees and help managing restaurant operational and result informations completely and accurately, so can give the best service to customers

AMELIORATIVE EFFECTS OF DIFFERENT PARTS OF GEMOR (NOTHAPHOEBE CORIACEA) ON CADMIUM INDUCED GLUCOSE METABOLISM ALTERATION IN VITRO

Objective: The present study was undertaken to investigate the ameliorative effect of the bark and leaves of Nothaphoebe coriacea (gemor) on Cadmium (Cd) induced glucose metabolism alteration in liver homogenate in vitro. Methods: Glucose metabolism alteration in liver homogenate was induced by the administration of Cadmium Sulphate (CdSO4) at a dose 3 mg/l. Ameliorative effect of the leaves and bark extracts was determined by assessing the concentration of glycogen, glucose and Methylglyoxal (MG). Dubois hydrolytic method was used for liver glycogen and glucose concentration estimation. Modified Dinitro Phenyl Hydrazine (DNPH) method was used for MG concentration estimation. Results: The results of this present studies showed that treatment with CdSO4 significantly decreased the levels of glycogen and MG concentration, and increased the level of glucose in liver homogenate compared to control. The aqueous extracts of bark and leaves of gemor significantly increased the levels of glycogen and MG concentration, and decreased the level of glucose in liver homogenate compared to control. The aqueous extracts of the bark of gemor in comparison with CdSO4 treatment group showed the significant effect to maintain the glycogen, glucose, and MG concentration in liver homogenate. However, when compared to the aqueous extracts of leaves of gemor the result was not significant. The results suggest aqueous extracts of the bark of gemor was more effective to prevent the glucose metabolism alteration induced by CdSO4 than the aqueous extracts of leaves of gemor. Conclusion: The present study demonstrated Cd could induced the glucose metabolism alteration in liver homogenate, and the aqueous extracts of bark and leaves of gemor showed the ameliorative effect to prevent this alteration. In addition, the bark was more effective than leaves of gemor to prevent the glucose metabolism alteration induced by Cd

Uji aktivitas antioksidan jus buah mengkudu (Morinda citrifolia) dan perannya sebagai inhbitor advanced glycation end products (AGEs) akibat reaksi glikosilasi

Background: Mengkudu is a traditional plant with active compound that has antioxidant activity. Diabetes mellitus complication has causative link with AGEs formation that involves free radical. Objective: To know antioxidant activity of mengkudu and the role to inhibit AGEs formation. Methods: This experiment used pre and post test control group design. Antioxidant activity was determined by reacting the mengkudu juice with 2,4 dinitrophenylhydrazin (DNPH) and analyzed with spectrophotometer X=390 nm. AGEs absorbancy was measured every 48 hours until 20 days with spectrophotometer ?=340 nm. Dicarbonyl level was determined with DNPH method that was developed by Uchida and modified by Sadikin. Result: Antioxidant activity of 0.25 g/mI mengkudu juice (Morinda citrifolia) was 125.46±27.79%. Beside that, mengkudu juice can inhibit advanced glycation end products (AGEs) formation. Conclusion: formationMengkudu juice can decrease AGEs formation and has antioxidant activity. Key words: antioxidant - mengkudu juice - AGEs - glycosilatio

Model pembentukan Advanced Glycation End Products (AGEs) dan degradasi tirosin akibat reaksi maillard

Maillard reaction or glycosylation reaction is a reaction between amine group and aldehyde group from glucose to form dicarbonyl compound and Advanced Glycation End Products (AGEs). The formation of AGEs have a role in diabetic complications. This work was conducted study the tyrosine degradation reaction model and the formation of AGEs caused by Maillard reaction. The research design was an experimental study with pre and posttest control group design with followed up posttest in 48 hours to 20 days. Two solutions, A and B were used; solution A was a mixture of BSA 30% + buffer phosphate pH 7 + aquadest, and solution B was BSA 30%+ buffer phosphate pH 7+ aquadest+ glucose. The degradation of tyrosine was measured by its absorbance at l=470 nm and the absorbance of AGEs formation at l=340 nm. Model of AGEs formation in solution A followed the equation of Y=0,0289X – 0,01847 with correlation coefficient R2=0,9767, where as that in solution B followed equation of Y=0,6552X – 1,5267 with correlation coefficient R2=0,9463. The tyrosine degradation model in solution A followed equation of Y=-0,1232X + 2,7166 with correlations coefficient R2=0,9175 where as that in solution B followed equation of Y=-0,03552X + 0,7762 with coefficient of correlation R2=0,9175. Negative value was observed in correlation between AGEs absorbance with tyrosine in solution A and B reflecting the formation of AGEs followed by tyrosine degradatio

Pemodelan Protein dengan Homology Modeling menggunakan SWISS-MODEL: Protein Modeling with Homology Modeling using SWISS-MODEL

The three-dimensional (3D) structure of proteins is necessary to understand the properties and functions of proteins. Determining protein structure by laboratory equipment is quite complicated and expensive. An alternative method to predict the 3D structure of proteins in the in silico method. One of the in silico methods is homology modeling. Homology modeling is done using the SWISS-MODEL server. Proteins that will be modeled in the 3D structure are proteins that do not yet have a structure in the RCSB PDB database. Protein sequences were obtained from the UniProt database with code A0A0B6VWS2. The results showed that there were two models selected, namely model-1 with the PDB code template 1q0e and model-2 with the PDB code template 3gtv. The results of sequence alignment and model visualization show that model-1 and model-2 are identical. The evaluation and assessment of model-1 on the Ramachandran Plot have a Favored area of ??97.36%, a MolProbity score of 0.79, and a QMEAN value is 1.13. Model-1 is a good 3D protein structure model

Antioksidatif estrogen dalam menghambat advanced oxidation protein product akibat reaksi glikosilasi

Ethinyl estradiol is an estrogen derivative used as contraceptive or hormone replacement therapy to maintain woman’s sexual function. The aim of this study was to examine ethinyl estradiol antioxidative activity and its potency to inhibit protein oxidation by glycocylation reaction. This study was an in vitro assay and its antioxidative activity by H2O2 scavenging, •OH scavenging, metal chelating were measured. Activity as inhibitor of Advanced Oxidation Protein Products (AOPP) was carried out by using glycocylation reaction. Three groups (n=6), i.e P0 control (3 ml of serum), P1 (3 ml of serum + glucose 500 mM), and P2 (3 ml of serum + glucose 500 mM + ethinyl estradiol 0,15gr/100mL) were used in this study. The result of this study showed that H2O2 scavenging, •OH scavenging, metal chelating were 48,889%, 15,139%, 11,538% respectively. For AOPP inhibition, P0 and P1 was different significantly (p0,05), P0 and P2 was not different significantly (p0,05), and P1 and P2 was different significantly (p0,05). It was suggested that antioxidative mechanism from ethinyl estradiol could inhibit AOPP formation generated by glycocylation reaction

Pemodelan reaksi glikosilasi dan peran infus daun tapak dara (Catharanthus roseus [L] G. Don) sebagai penghambat kerusakan protein

ABSTRACT Rizky Taufan Firdaus, Eko Suhartono, Nur Qamariah - Glycosilation reaction models and the role of Madagascar periwinkle (Catharanthus roseus CU G. Don)\u27 S leaves infusion as protein damage inhibitor Background : Glycosilation is a reaction between protein and glucose in high concentration. The basic of this reaction is the continuous increase of glucose concentration, followed by a hooking between glucose with the amin primary structure of the protein. Beside form the AGEs, glycosilation reaction forms free radicals as the side product. The free radical reaction with the protein forms a crosslinking of the protein and then change the structure of the protein. Objectives : This research was carried out to know glycosilation reaction model and the role of madagascar periwinkle ICatharanthus roseus ELI G. Don)\u27 s leaves infusion as protein damage inhibitor. Method : This research is an experimental and explorative research. This research was carried out in two steps, the making of infusion and the test for protein damage inhibition by using the infusion of madagascar periwinkle\u27 s leaves and glyclazide. Result : The activity of madagascar periwinkle\u27s leaves infusion to inhibit the protein damage is 21,29% while the activity of glyclazide is 96,77%. Conclusion : The infusion of madagascar periwinkle (Caiharanihus roseus EL.] G. Don)\u27s leaves can inhibit the protein damage because of the glycosilation reaction but lower than the glyclazide\u27s. Key words : Madagascar periwinkle - glycosilation - free radical - protein damag

Local Government Preparedness in Response to the Transition from Pandemic to Endemic: An Adaptive Governance Perspective in Surabaya Municipality

According to the declaration of the WHO about the pandemic, COVID-19 is pathogenic in humans. Leaders around the world have implemented strategies to prevent the transmission of this outbreak. The Indonesian government also encountered a similar problem, with the first case of COVID-19 in Indonesia announced around March 2020. Soon after, the number of cases increased dramatically over time. Months later, the Indonesian government distributed the vaccination program throughout the country, reaching more than 70% of the population. As the immune system strengthens, the government is planning a transition from pandemic to endemic based on the condition of each area. Adaptive governance is needed during this transition, and according to that, the local government plays an important role in dealing with the endemic. Further research has been conducted in Surabaya, one of the largest cities in Indonesia with a heterogeneous population. This study used Soft System Methodology to create a model of bureaucracy between local governments in Surabaya, and the results showed that in the relationship between local governments, the mayor of Surabaya Municipality has to be the main commander, with the regional disaster management agency as the leading sector. However, the results showed that adaptive governance in Surabaya has been effectively implemented. This study is expected to be one of the references in preparing for the transition from pandemic to endemic by using an adaptive governance perspective